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Protein
Submitted name:

Drosophila CRumBs homolog

Gene

crb-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Drosophila CRumBs homologImported
Gene namesi
Name:crb-1Imported
ORF Names:CELE_F11C7.4Imported, F11C7.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF11C7.4; CE07053; WBGene00000792; crb-1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1659 – 1685HelicalSequence analysisAdd BLAST27

GO - Cellular componenti

  • apical part of cell Source: WormBase
  • cytoplasm Source: WormBase
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500418712424 – 1722Sequence analysisAdd BLAST1699

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ19350.
PeptideAtlasiQ19350.

Expressioni

Gene expression databases

BgeeiWBGene00000792.

Interactioni

Protein-protein interaction databases

IntActiQ19350. 8 interactors.
STRINGi6239.F11C7.4.

Structurei

3D structure databases

ProteinModelPortaliQ19350.
SMRiQ19350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 56EGF-likeInterPro annotationAdd BLAST38
Domaini57 – 90EGF-likeInterPro annotationAdd BLAST34
Domaini125 – 161EGF-likeInterPro annotationAdd BLAST37
Domaini163 – 199EGF-likeInterPro annotationAdd BLAST37
Domaini202 – 238EGF-likeInterPro annotationAdd BLAST37
Domaini242 – 279EGF-likeInterPro annotationAdd BLAST38
Domaini282 – 319EGF-likeInterPro annotationAdd BLAST38
Domaini320 – 358EGF-likeInterPro annotationAdd BLAST39
Domaini365 – 402EGF-likeInterPro annotationAdd BLAST38
Domaini403 – 439EGF-likeInterPro annotationAdd BLAST37
Domaini468 – 502EGF-likeInterPro annotationAdd BLAST35
Domaini504 – 544EGF-likeInterPro annotationAdd BLAST41
Domaini553 – 712LAM_G_DOMAINInterPro annotationAdd BLAST160
Domaini714 – 750EGF-likeInterPro annotationAdd BLAST37
Domaini756 – 947LAM_G_DOMAINInterPro annotationAdd BLAST192
Domaini943 – 978EGF-likeInterPro annotationAdd BLAST36
Domaini1173 – 1210EGF-likeInterPro annotationAdd BLAST38
Domaini1212 – 1248EGF-likeInterPro annotationAdd BLAST37
Domaini1250 – 1287EGF-likeInterPro annotationAdd BLAST38
Domaini1290 – 1327EGF-likeInterPro annotationAdd BLAST38
Domaini1330 – 1365EGF-likeInterPro annotationAdd BLAST36
Domaini1367 – 1403EGF-likeInterPro annotationAdd BLAST37
Domaini1405 – 1442EGF-likeInterPro annotationAdd BLAST38
Domaini1443 – 1479EGF-likeInterPro annotationAdd BLAST37
Domaini1481 – 1517EGF-likeInterPro annotationAdd BLAST37
Domaini1519 – 1556EGF-likeInterPro annotationAdd BLAST38
Domaini1558 – 1594EGF-likeInterPro annotationAdd BLAST37
Domaini1609 – 1648EGF-likeInterPro annotationAdd BLAST40

Keywords - Domaini

EGF-like domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
GeneTreeiENSGT00810000125346.
HOGENOMiHOG000020775.
InParanoidiQ19350.
OMAiNGHYCIF.
OrthoDBiEOG091G001C.
PhylomeDBiQ19350.

Family and domain databases

Gene3Di2.60.120.200. 3 hits.
InterProiIPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR013111. EGF_extracell.
IPR003645. Fol_N.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00008. EGF. 7 hits.
PF07974. EGF_2. 1 hit.
PF07645. EGF_CA. 1 hit.
PF12661. hEGF. 4 hits.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 26 hits.
SM00179. EGF_CA. 19 hits.
SM00274. FOLN. 5 hits.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 3 hits.
PROSITEiPS00010. ASX_HYDROXYL. 5 hits.
PS00022. EGF_1. 24 hits.
PS01186. EGF_2. 19 hits.
PS50026. EGF_3. 26 hits.
PS01187. EGF_CA. 3 hits.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q19350-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYQHFLIFC TLVTNALCNR ACSRNTCLNG GTCTVNDETR MFQCECPKGF
60 70 80 90 100
SGLLCQDNCS LHCLHGNCVK GTFGEETCQC SEGWMGSLCD NLVTDDDTAQ
110 120 130 140 150
KCSPQCGDDE RCTKGADGSY ICQSNEPSCA THTCQNNGTC VAENGNVKCA
160 170 180 190 200
CPPGFVGDHC ETDEDECKEN FCQNGADCEN LKGSYECKCL KGFSGKYCEI
210 220 230 240 250
QDKKQCTSDY CHNNGQCIST GSDLSCKCSP GFDGAFCELK AEVNECICEN
260 270 280 290 300
PAHVCSLVNG TSRTTQCECP SGFMGADCKE LQARPCDREP CLNGGHCVDD
310 320 330 340 350
GQNLFTCFCL PSFTGIYCGE PVDCLVNGSD CKNGGKCVFA LAATTCQCPE
360 370 380 390 400
GFNGSNCEIS NSYRSHPTCS DIRCLNGGSC KLDAEGEPFC VCEEGFDGPF
410 420 430 440 450
CEPKSGCTIN PCQNGGTCQD ADGQYFCHCT SGFGGVHCET VDEPSTPIPT
460 470 480 490 500
LGTFPSFTTS GIDGFSQSKI SCEDCVNSSN CLDVESGPVC ICDDGYFGQK
510 520 530 540 550
CDQKHDKCSK VSCPSGQTCS QVNDNVNITA QCGCEIGHFG QQCEMVTSAT
560 570 580 590 600
FSAKSLYIHQ SSKFSLGTSS FENIAYELEF SFRTTVENTH LASSENILGE
610 620 630 640 650
KILSIQLLSG YLVFNMTGNS LEHLLPMRVS DAQWYTVFVK GEDNKIQIEV
660 670 680 690 700
STENGFSLVQ KSVNGQLEVF LTRFGKISGT HHFIGCMADV RVDGDLIIFA
710 720 730 740 750
DNKRAIDIRK GCTRSEQCTR AYCQNEGICI DHWESSSCKC KPPYLKPNCV
760 770 780 790 800
YFLPKTTFGH LDQPSIVHLS TSESENHLLR NHIELSFLMH SGKPDAVLFY
810 820 830 840 850
IGEKHAADVL TNYLVVKIAG GLITVRYRTG GRREIEFSSK NRVDDNQEHH
860 870 880 890 900
VQIFLDKTTR QIIIDDLIEC SEPIISRMSQ EFYVDDIVIG ASNVVATDSE
910 920 930 940 950
FYKGYLQDIQ INQKSVVIHP TSLTIDKIGK LERTQNVIEG AVSDPMCSSS
960 970 980 990 1000
TCKHGECSET FNDFTCRCSD GSTGKLCDKV DYCKDASCMK GSRCENADNG
1010 1020 1030 1040 1050
HYCIFPITIS NGSMLTYSLA PTKFMTLPSI EFSIKAHSQN GHIFTLTIDK
1060 1070 1080 1090 1100
STLSAYLFKK RLALATNSGS GTIQKFDSVI ADGNWHQIIL NPHKVLIDSV
1110 1120 1130 1140 1150
KFISDNQLYP AESKSGASLF VGEQEPQEVT FACLDLFKMG EYPTLSFTKV
1160 1170 1180 1190 1200
KIPTNSETWN LTDKASVGTG CMSTDQCGLY STCLNGATCV DIWNKRKCVC
1210 1220 1230 1240 1250
PAGFAGENCE DNVNDCKFVD CGKHGYCLDG IDEAKCICNN GFHGEHCELA
1260 1270 1280 1290 1300
KDECEGVECH NGGKCVKNRS EKIVCQCGNS WMGDSCNVTK TTNCKDSPCQ
1310 1320 1330 1340 1350
NFGQCMQKTD TFFECNCMDG YSGELCEQRD VNECNHYDCN RGHCVMTVSG
1360 1370 1380 1390 1400
PACQCEMGYT GRFCEKLLNQ CSSNTCSSRG ACSPVWNNTV CNCDNNWRGA
1410 1420 1430 1440 1450
HCQHQMDTCL DFPCNNDGVC RTNDENTFSC ECQKFFMGTR CEIEGSCLKA
1460 1470 1480 1490 1500
QCVHGECIQL SPETHTCSCN IGYEGDACDK KIDYCKAGPC LNGANCENKL
1510 1520 1530 1540 1550
TGYKCTCAVG FEGADCEINI DECALEFCKN GAKCRDKIND YECVCDGTGF
1560 1570 1580 1590 1600
EGRNCTTDIN ECANPNNCIN GECTNTLGNY KCACRNGFIG PRCSVRNPCT
1610 1620 1630 1640 1650
AQIASNNISS VTCVHGKCVN PVVQIEKNRE VAKYECACDR GYTGPTCSQR
1660 1670 1680 1690 1700
IKESAMSNIS YLFGPIIAVV IVFAILGCLL LFFVIRGNNA MHGHYSPSSH
1710 1720
EFTQNRMAMP TVIKLPPQER LI
Length:1,722
Mass (Da):188,385
Last modified:November 1, 1996 - v1
Checksum:iE74A3B6D9A2BDC31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD66913.1.
PIRiE89753.
RefSeqiNP_510822.1. NM_078421.3.
UniGeneiCel.38736.

Genome annotation databases

EnsemblMetazoaiF11C7.4; F11C7.4; WBGene00000792.
GeneIDi181771.
KEGGicel:CELE_F11C7.4.
UCSCiF11C7.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD66913.1.
PIRiE89753.
RefSeqiNP_510822.1. NM_078421.3.
UniGeneiCel.38736.

3D structure databases

ProteinModelPortaliQ19350.
SMRiQ19350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ19350. 8 interactors.
STRINGi6239.F11C7.4.

Proteomic databases

PaxDbiQ19350.
PeptideAtlasiQ19350.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF11C7.4; F11C7.4; WBGene00000792.
GeneIDi181771.
KEGGicel:CELE_F11C7.4.
UCSCiF11C7.4. c. elegans.

Organism-specific databases

CTDi181771.
WormBaseiF11C7.4; CE07053; WBGene00000792; crb-1.

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
GeneTreeiENSGT00810000125346.
HOGENOMiHOG000020775.
InParanoidiQ19350.
OMAiNGHYCIF.
OrthoDBiEOG091G001C.
PhylomeDBiQ19350.

Miscellaneous databases

PROiQ19350.

Gene expression databases

BgeeiWBGene00000792.

Family and domain databases

Gene3Di2.60.120.200. 3 hits.
InterProiIPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR013111. EGF_extracell.
IPR003645. Fol_N.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00008. EGF. 7 hits.
PF07974. EGF_2. 1 hit.
PF07645. EGF_CA. 1 hit.
PF12661. hEGF. 4 hits.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 26 hits.
SM00179. EGF_CA. 19 hits.
SM00274. FOLN. 5 hits.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 3 hits.
PROSITEiPS00010. ASX_HYDROXYL. 5 hits.
PS00022. EGF_1. 24 hits.
PS01186. EGF_2. 19 hits.
PS50026. EGF_3. 26 hits.
PS01187. EGF_CA. 3 hits.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ19350_CAEEL
AccessioniPrimary (citable) accession number: Q19350
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.