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Protein

Nuclear hormone receptor family member nhr-25

Gene

nhr-25

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Orphan nuclear receptor. Seems to be required during development. Disruption of nhr-25 function leads to embryonic arrest due to failure of the epidermally mediated process of embryo elongation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi15 – 90Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri18 – 38NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri54 – 78NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • hormone-mediated signaling pathway Source: GO_Central
  • molting cycle, collagen and cuticulin-based cuticle Source: WormBase
  • multicellular organism development Source: UniProtKB-KW
  • positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  • tissue development Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear hormone receptor family member nhr-25
Gene namesi
Name:nhr-25
ORF Names:F11C1.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF11C1.6a; CE03191; WBGene00003623; nhr-25.
F11C1.6b; CE35856; WBGene00003623; nhr-25.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537741 – 572Nuclear hormone receptor family member nhr-25Add BLAST572

Proteomic databases

EPDiQ19345.
PaxDbiQ19345.
PeptideAtlasiQ19345.

Expressioni

Tissue specificityi

Expressed in the epidermis, the developing somatic gonad, and a subset of other epithelial cells.1 Publication

Gene expression databases

BgeeiWBGene00003623.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • armadillo repeat domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi46336. 4 interactors.
IntActiQ19345. 2 interactors.
STRINGi6239.F11C1.6a.

Structurei

3D structure databases

ProteinModelPortaliQ19345.
SMRiQ19345.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri18 – 38NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri54 – 78NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4218. Eukaryota.
ENOG410YWC2. LUCA.
GeneTreeiENSGT00760000118887.
HOGENOMiHOG000021002.
InParanoidiQ19345.
OMAiRPNHEGE.
OrthoDBiEOG091G06RK.
PhylomeDBiQ19345.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR016355. NR5_fam.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PANTHERiPTHR24086. PTHR24086. 1 hit.
PfamiView protein in Pfam
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 2 hits.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q19345-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDVERMVLR PNHEGEMCPV CGDRVSGYHY GLLTCESCKG FFKRTVQNKK
60 70 80 90 100
QYQCSAEANC HVDRTCRKRC PSCRFQKCLT MGMKMEAVRA DRMRGGRNKF
110 120 130 140 150
GSFYKKDRAH RMQRNAMRVS TVQVPAVLGA QSQAQTFYQP PEHQVSSSTT
160 170 180 190 200
DQNNQINYFD QTKIKTEYIK TEYDAHLQSP TLSSSTNQQL SVSDFIMRPG
210 220 230 240 250
YLVDPQDSLA VLLGSTIDDP LLRHTFPAAY QLNEVKQEPF DYSEQFIHHS
260 270 280 290 300
LHDYPTYTSN TTNYATMMPM TTVSSTQSLV TSTSSTTTGR MTEASSTSPI
310 320 330 340 350
LPLCPAPTEK TVDHFYNSSI AEMCKTLPDD AQIARIFTSV KGTSKPEKHA
360 370 380 390 400
FSIQVAEENL KDIVIWAKND QLFSKLSLDD QMILLQTSWT TVHIVDITNA
410 420 430 440 450
MVHGNLLSQY KMSNGDEVPV GLVALLGNQT FVSSWNDVVI RLRNMGFTNF
460 470 480 490 500
DYCAFRFLAL FDQSMDSFPA VSTARSRVLQ SWREVRCTTA FLEIFEQIRR
510 520 530 540 550
LAYDSLRYLW NLHSNCPTNW EQFFPEASLV LEMIRTTVNR SASSSVTAIT
560 570
QVPAIQLPTP QATYTAVPYM AS
Length:572
Mass (Da):64,772
Last modified:November 1, 1996 - v1
Checksum:iD3092AE533092D7A
GO
Isoform b (identifier: Q19345-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.

Show »
Length:492
Mass (Da):55,521
Checksum:i666A99A41C0E2404
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100F → L in AAF67039 (PubMed:10772806).Curated1
Sequence conflicti540R → Q in AAF67039 (PubMed:10772806).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0037231 – 80Missing in isoform b. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179214 mRNA. Translation: AAF67038.1.
AF179215 mRNA. Translation: AAF67039.1.
AF179216 mRNA. Translation: AAF67040.1.
Z54270 Genomic DNA. Translation: CAA91028.1.
Z54270 Genomic DNA. Translation: CAE48496.1.
PIRiT20764.
RefSeqiNP_001024550.1. NM_001029379.2. [Q19345-1]
NP_001024551.1. NM_001029380.3. [Q19345-2]
UniGeneiCel.7338.

Genome annotation databases

EnsemblMetazoaiF11C1.6a; F11C1.6a; WBGene00003623. [Q19345-1]
GeneIDi181432.
KEGGicel:CELE_F11C1.6.
UCSCiF11C1.6b.2. c. elegans. [Q19345-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNHR25_CAEEL
AccessioniPrimary (citable) accession number: Q19345
Secondary accession number(s): Q7JMA3
, Q9NJ95, Q9NJ96, Q9NJ97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families