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Q19341

- 3HAO_CAEEL

UniProt

Q19341 - 3HAO_CAEEL

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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

haao-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+ ion.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451DioxygenUniRule annotation
Metal bindingi49 – 491Iron; catalyticUniRule annotation
Metal bindingi55 – 551Iron; catalyticUniRule annotation
Binding sitei55 – 551SubstrateUniRule annotation
Metal bindingi93 – 931Iron; catalyticUniRule annotation
Binding sitei97 – 971SubstrateUniRule annotation
Binding sitei107 – 1071SubstrateUniRule annotation

GO - Molecular functioni

  1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
  2. ferrous iron binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
Alternative name(s):
3-hydroxyanthranilate oxygenaseUniRule annotation
Short name:
3-HAOUniRule annotation
3-hydroxyanthranilic acid dioxygenaseUniRule annotation
Short name:
HADUniRule annotation
Gene namesi
Name:haao-1
ORF Names:K06A4.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiK06A4.5; CE06109; WBGene00010595; haao-1.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2812813-hydroxyanthranilate 3,4-dioxygenasePRO_0000245470Add
BLAST

Proteomic databases

PaxDbiQ19341.
PRIDEiQ19341.

2D gel databases

World-2DPAGE0011:Q19341.

Interactioni

Protein-protein interaction databases

BioGridi44367. 2 interactions.
IntActiQ19341. 5 interactions.
MINTiMINT-116934.
STRINGi6239.K06A4.5.

Structurei

3D structure databases

ProteinModelPortaliQ19341.
SMRiQ19341. Positions 12-241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 162162Domain A (catalytic)UniRule annotationAdd
BLAST
Regioni163 – 17917LinkerUniRule annotationAdd
BLAST
Regioni180 – 281102Domain BUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the 3-HAO family.UniRule annotation

Phylogenomic databases

eggNOGiNOG77058.
GeneTreeiENSGT00390000013008.
HOGENOMiHOG000218448.
InParanoidiQ19341.
KOiK00452.
OMAiDMCLKVI.
OrthoDBiEOG7FFMS4.
PhylomeDBiQ19341.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR016700. 3hydroanth_dOase_met.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
PIRSFiPIRSF017681. 3hydroanth_dOase_animal. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q19341-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGVTAIEIP QWIQDNQEDF VPPVCNKCMF SDQLKVFYVG GPNQRKDFHL
60 70 80 90 100
EEGEEFFFQR KGDMVLKVIE KGQVRDLVIK QGEMFMLPAR VEHSPQRFSN
110 120 130 140 150
SIGLVVERER KNTEFDCVRF LVGSSNITLF ERWFYLTDVV KDLPPLIKEF
160 170 180 190 200
YGSNEFKTGK PGKGTFACNA PYEARWTDLP VPINRKEFIY DHISEVKNGP
210 220 230 240 250
VRIYGAPEYK TEVMLLGEGS YDLESGTVEL LIWLQENTFA VVEESGFTYA
260 270 280
MKSETMVRIK PNTKCLLNVK GGFAITIRMP A
Length:281
Mass (Da):32,227
Last modified:November 1, 1998 - v2
Checksum:iE3DD76D60D5930A9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z70755, Z70751 Genomic DNA. Translation: CAA94787.1.
PIRiT20743.
RefSeqiNP_505450.1. NM_073049.1.
UniGeneiCel.3124.

Genome annotation databases

EnsemblMetazoaiK06A4.5; K06A4.5; WBGene00010595.
GeneIDi179329.
KEGGicel:CELE_K06A4.5.
UCSCiK06A4.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z70755 , Z70751 Genomic DNA. Translation: CAA94787.1 .
PIRi T20743.
RefSeqi NP_505450.1. NM_073049.1.
UniGenei Cel.3124.

3D structure databases

ProteinModelPortali Q19341.
SMRi Q19341. Positions 12-241.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 44367. 2 interactions.
IntActi Q19341. 5 interactions.
MINTi MINT-116934.
STRINGi 6239.K06A4.5.

2D gel databases

World-2DPAGE 0011:Q19341.

Proteomic databases

PaxDbi Q19341.
PRIDEi Q19341.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai K06A4.5 ; K06A4.5 ; WBGene00010595 .
GeneIDi 179329.
KEGGi cel:CELE_K06A4.5.
UCSCi K06A4.5. c. elegans.

Organism-specific databases

CTDi 179329.
WormBasei K06A4.5 ; CE06109 ; WBGene00010595 ; haao-1.

Phylogenomic databases

eggNOGi NOG77058.
GeneTreei ENSGT00390000013008.
HOGENOMi HOG000218448.
InParanoidi Q19341.
KOi K00452.
OMAi DMCLKVI.
OrthoDBi EOG7FFMS4.
PhylomeDBi Q19341.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00330 .

Miscellaneous databases

NextBioi 904940.
PROi Q19341.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
HAMAPi MF_00825. 3_HAO.
InterProi IPR010329. 3hydroanth_dOase.
IPR016700. 3hydroanth_dOase_met.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR15497. PTHR15497. 1 hit.
Pfami PF06052. 3-HAO. 1 hit.
[Graphical view ]
PIRSFi PIRSF017681. 3hydroanth_dOase_animal. 1 hit.
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry namei3HAO_CAEEL
AccessioniPrimary (citable) accession number: Q19341
Secondary accession number(s): Q21258
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3