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Q19341 (3HAO_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-hydroxyanthranilate 3,4-dioxygenase

EC=1.13.11.6
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name=3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name=HAD
Gene names
Name:haao-1
ORF Names:K06A4.5
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity. HAMAP-Rule MF_03019

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP-Rule MF_03019

Cofactor

Fe2+ ion By similarity. HAMAP-Rule MF_03019

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. HAMAP-Rule MF_03019

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_03019.

Sequence similarities

Belongs to the 3-HAO family.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNAD biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-hydroxyanthranilate 3,4-dioxygenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2812813-hydroxyanthranilate 3,4-dioxygenase HAMAP-Rule MF_03019
PRO_0000245470

Regions

Region1 – 162162Domain A (catalytic) By similarity
Region163 – 17917Linker By similarity
Region180 – 281102Domain B By similarity

Sites

Metal binding491Iron; catalytic By similarity
Metal binding551Iron; catalytic By similarity
Metal binding931Iron; catalytic By similarity
Binding site451Dioxygen By similarity
Binding site551Substrate By similarity
Binding site971Substrate By similarity
Binding site1071Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q19341 [UniParc].

Last modified November 1, 1998. Version 2.
Checksum: E3DD76D60D5930A9

FASTA28132,227
        10         20         30         40         50         60 
MSGVTAIEIP QWIQDNQEDF VPPVCNKCMF SDQLKVFYVG GPNQRKDFHL EEGEEFFFQR 

        70         80         90        100        110        120 
KGDMVLKVIE KGQVRDLVIK QGEMFMLPAR VEHSPQRFSN SIGLVVERER KNTEFDCVRF 

       130        140        150        160        170        180 
LVGSSNITLF ERWFYLTDVV KDLPPLIKEF YGSNEFKTGK PGKGTFACNA PYEARWTDLP 

       190        200        210        220        230        240 
VPINRKEFIY DHISEVKNGP VRIYGAPEYK TEVMLLGEGS YDLESGTVEL LIWLQENTFA 

       250        260        270        280 
VVEESGFTYA MKSETMVRIK PNTKCLLNVK GGFAITIRMP A 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z70755, Z70751 Genomic DNA. Translation: CAA94787.1.
PIRT20743.
RefSeqNP_505450.1. NM_073049.1.
UniGeneCel.3124.

3D structure databases

ProteinModelPortalQ19341.
SMRQ19341. Positions 4-279.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid44367. 2 interactions.
IntActQ19341. 5 interactions.
MINTMINT-116934.
STRING6239.K06A4.5.

2D gel databases

World-2DPAGE0011:Q19341.

Proteomic databases

PaxDbQ19341.
PRIDEQ19341.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaK06A4.5; K06A4.5; K06A4.5.
GeneID179329.
KEGGcel:CELE_K06A4.5.
UCSCK06A4.5. c. elegans.

Organism-specific databases

CTD179329.
WormBaseK06A4.5; CE06109; WBGene00010595; haao-1.

Phylogenomic databases

eggNOGNOG77058.
HOGENOMHOG000218448.
InParanoidQ19341.
KOK00452.
OMADMCLKVI.
OrthoDBEOG7FFMS4.
PhylomeDBQ19341.

Enzyme and pathway databases

UniPathwayUPA00253; UER00330.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
HAMAPMF_00825. 3_HAO.
InterProIPR010329. 3hydroanth_dOase.
IPR016700. 3hydroanth_dOase_met.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
PIRSFPIRSF017681. 3hydroanth_dOase_animal. 1 hit.
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR03037. anthran_nbaC. 1 hit.
ProtoNetSearch...

Other

NextBio904940.
PROQ19341.

Entry information

Entry name3HAO_CAEEL
AccessionPrimary (citable) accession number: Q19341
Secondary accession number(s): Q21258
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase