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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

haao-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathway:iNAD(+) biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (kmo-1)
  2. Kynureninase (flu-2)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (haao-1)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451DioxygenUniRule annotation
Metal bindingi49 – 491Iron; catalyticUniRule annotation
Metal bindingi55 – 551Iron; catalyticUniRule annotation
Binding sitei55 – 551SubstrateUniRule annotation
Metal bindingi93 – 931Iron; catalyticUniRule annotation
Binding sitei97 – 971SubstrateUniRule annotation
Binding sitei107 – 1071SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_336244. Tryptophan catabolism.
UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
Alternative name(s):
3-hydroxyanthranilate oxygenaseUniRule annotation
Short name:
3-HAOUniRule annotation
3-hydroxyanthranilic acid dioxygenaseUniRule annotation
Short name:
HADUniRule annotation
Gene namesi
Name:haao-1
ORF Names:K06A4.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiK06A4.5; CE06109; WBGene00010595; haao-1.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2812813-hydroxyanthranilate 3,4-dioxygenasePRO_0000245470Add
BLAST

Proteomic databases

PaxDbiQ19341.
PRIDEiQ19341.

2D gel databases

World-2DPAGE0011:Q19341.

Interactioni

Protein-protein interaction databases

BioGridi44367. 2 interactions.
IntActiQ19341. 5 interactions.
MINTiMINT-116934.
STRINGi6239.K06A4.5.

Structurei

3D structure databases

ProteinModelPortaliQ19341.
SMRiQ19341. Positions 12-241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 162162Domain A (catalytic)UniRule annotationAdd
BLAST
Regioni163 – 17917LinkerUniRule annotationAdd
BLAST
Regioni180 – 281102Domain BUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the 3-HAO family.UniRule annotation

Phylogenomic databases

eggNOGiNOG77058.
GeneTreeiENSGT00390000013008.
HOGENOMiHOG000218448.
InParanoidiQ19341.
KOiK00452.
OMAiQENTFAV.
OrthoDBiEOG7FFMS4.
PhylomeDBiQ19341.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR016700. 3hydroanth_dOase_met.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
PIRSFiPIRSF017681. 3hydroanth_dOase_animal. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q19341-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGVTAIEIP QWIQDNQEDF VPPVCNKCMF SDQLKVFYVG GPNQRKDFHL
60 70 80 90 100
EEGEEFFFQR KGDMVLKVIE KGQVRDLVIK QGEMFMLPAR VEHSPQRFSN
110 120 130 140 150
SIGLVVERER KNTEFDCVRF LVGSSNITLF ERWFYLTDVV KDLPPLIKEF
160 170 180 190 200
YGSNEFKTGK PGKGTFACNA PYEARWTDLP VPINRKEFIY DHISEVKNGP
210 220 230 240 250
VRIYGAPEYK TEVMLLGEGS YDLESGTVEL LIWLQENTFA VVEESGFTYA
260 270 280
MKSETMVRIK PNTKCLLNVK GGFAITIRMP A
Length:281
Mass (Da):32,227
Last modified:November 1, 1998 - v2
Checksum:iE3DD76D60D5930A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70755, Z70751 Genomic DNA. Translation: CAA94787.1.
PIRiT20743.
RefSeqiNP_505450.1. NM_073049.1.
UniGeneiCel.3124.

Genome annotation databases

EnsemblMetazoaiK06A4.5; K06A4.5; WBGene00010595.
GeneIDi179329.
KEGGicel:CELE_K06A4.5.
UCSCiK06A4.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70755, Z70751 Genomic DNA. Translation: CAA94787.1.
PIRiT20743.
RefSeqiNP_505450.1. NM_073049.1.
UniGeneiCel.3124.

3D structure databases

ProteinModelPortaliQ19341.
SMRiQ19341. Positions 12-241.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44367. 2 interactions.
IntActiQ19341. 5 interactions.
MINTiMINT-116934.
STRINGi6239.K06A4.5.

2D gel databases

World-2DPAGE0011:Q19341.

Proteomic databases

PaxDbiQ19341.
PRIDEiQ19341.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK06A4.5; K06A4.5; WBGene00010595.
GeneIDi179329.
KEGGicel:CELE_K06A4.5.
UCSCiK06A4.5. c. elegans.

Organism-specific databases

CTDi179329.
WormBaseiK06A4.5; CE06109; WBGene00010595; haao-1.

Phylogenomic databases

eggNOGiNOG77058.
GeneTreeiENSGT00390000013008.
HOGENOMiHOG000218448.
InParanoidiQ19341.
KOiK00452.
OMAiQENTFAV.
OrthoDBiEOG7FFMS4.
PhylomeDBiQ19341.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330.
ReactomeiREACT_336244. Tryptophan catabolism.

Miscellaneous databases

NextBioi904940.
PROiQ19341.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR016700. 3hydroanth_dOase_met.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
PIRSFiPIRSF017681. 3hydroanth_dOase_animal. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry namei3HAO_CAEEL
AccessioniPrimary (citable) accession number: Q19341
Secondary accession number(s): Q21258
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1998
Last modified: July 22, 2015
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.