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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

haao-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (kmo-1)
  2. Kynureninase (flu-2)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (haao-1)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45DioxygenUniRule annotation1
Metal bindingi49Iron; catalyticUniRule annotation1
Metal bindingi55Iron; catalyticUniRule annotation1
Binding sitei55SubstrateUniRule annotation1
Metal bindingi93Iron; catalyticUniRule annotation1
Binding sitei97SubstrateUniRule annotation1
Binding sitei107SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-71240. Tryptophan catabolism.
UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
Alternative name(s):
3-hydroxyanthranilate oxygenaseUniRule annotation
Short name:
3-HAOUniRule annotation
3-hydroxyanthranilic acid dioxygenaseUniRule annotation
Short name:
HADUniRule annotation
Gene namesi
Name:haao-1
ORF Names:K06A4.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiK06A4.5; CE06109; WBGene00010595; haao-1.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002454701 – 2813-hydroxyanthranilate 3,4-dioxygenaseAdd BLAST281

Proteomic databases

EPDiQ19341.
PaxDbiQ19341.
PeptideAtlasiQ19341.
PRIDEiQ19341.

2D gel databases

World-2DPAGE0011:Q19341.

Expressioni

Gene expression databases

BgeeiWBGene00010595.

Interactioni

Protein-protein interaction databases

BioGridi44367. 2 interactors.
IntActiQ19341. 5 interactors.
MINTiMINT-116934.
STRINGi6239.K06A4.5.

Structurei

3D structure databases

ProteinModelPortaliQ19341.
SMRiQ19341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 162Domain A (catalytic)UniRule annotationAdd BLAST162
Regioni163 – 179LinkerUniRule annotationAdd BLAST17
Regioni180 – 281Domain BUniRule annotationAdd BLAST102

Sequence similaritiesi

Belongs to the 3-HAO family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3995. Eukaryota.
ENOG4111GH8. LUCA.
GeneTreeiENSGT00390000013008.
HOGENOMiHOG000218448.
InParanoidiQ19341.
KOiK00452.
OMAiQLKVFYV.
OrthoDBiEOG091G0IJ1.
PhylomeDBiQ19341.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_00825. 3_HAO. 1 hit.
InterProiIPR010329. 3hydroanth_dOase.
IPR016700. 3hydroanth_dOase_met.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
PIRSFiPIRSF017681. 3hydroanth_dOase_animal. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q19341-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGVTAIEIP QWIQDNQEDF VPPVCNKCMF SDQLKVFYVG GPNQRKDFHL
60 70 80 90 100
EEGEEFFFQR KGDMVLKVIE KGQVRDLVIK QGEMFMLPAR VEHSPQRFSN
110 120 130 140 150
SIGLVVERER KNTEFDCVRF LVGSSNITLF ERWFYLTDVV KDLPPLIKEF
160 170 180 190 200
YGSNEFKTGK PGKGTFACNA PYEARWTDLP VPINRKEFIY DHISEVKNGP
210 220 230 240 250
VRIYGAPEYK TEVMLLGEGS YDLESGTVEL LIWLQENTFA VVEESGFTYA
260 270 280
MKSETMVRIK PNTKCLLNVK GGFAITIRMP A
Length:281
Mass (Da):32,227
Last modified:November 1, 1998 - v2
Checksum:iE3DD76D60D5930A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70755, Z70751 Genomic DNA. Translation: CAA94787.1.
PIRiT20743.
RefSeqiNP_505450.1. NM_073049.1.
UniGeneiCel.3124.

Genome annotation databases

EnsemblMetazoaiK06A4.5; K06A4.5; WBGene00010595.
GeneIDi179329.
KEGGicel:CELE_K06A4.5.
UCSCiK06A4.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70755, Z70751 Genomic DNA. Translation: CAA94787.1.
PIRiT20743.
RefSeqiNP_505450.1. NM_073049.1.
UniGeneiCel.3124.

3D structure databases

ProteinModelPortaliQ19341.
SMRiQ19341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44367. 2 interactors.
IntActiQ19341. 5 interactors.
MINTiMINT-116934.
STRINGi6239.K06A4.5.

2D gel databases

World-2DPAGE0011:Q19341.

Proteomic databases

EPDiQ19341.
PaxDbiQ19341.
PeptideAtlasiQ19341.
PRIDEiQ19341.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK06A4.5; K06A4.5; WBGene00010595.
GeneIDi179329.
KEGGicel:CELE_K06A4.5.
UCSCiK06A4.5. c. elegans.

Organism-specific databases

CTDi179329.
WormBaseiK06A4.5; CE06109; WBGene00010595; haao-1.

Phylogenomic databases

eggNOGiKOG3995. Eukaryota.
ENOG4111GH8. LUCA.
GeneTreeiENSGT00390000013008.
HOGENOMiHOG000218448.
InParanoidiQ19341.
KOiK00452.
OMAiQLKVFYV.
OrthoDBiEOG091G0IJ1.
PhylomeDBiQ19341.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330.
ReactomeiR-CEL-71240. Tryptophan catabolism.

Miscellaneous databases

PROiQ19341.

Gene expression databases

BgeeiWBGene00010595.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_00825. 3_HAO. 1 hit.
InterProiIPR010329. 3hydroanth_dOase.
IPR016700. 3hydroanth_dOase_met.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
PIRSFiPIRSF017681. 3hydroanth_dOase_animal. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry namei3HAO_CAEEL
AccessioniPrimary (citable) accession number: Q19341
Secondary accession number(s): Q21258
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.