Reviewed, UniProtKB/Swiss-Prot Q19341 (3HAO_CAEEL)

Names and origin

Protein names

Recommended name:
    3-hydroxyanthranilate 3,4-dioxygenase
    EC=1.13.11.6
Alternative name(s):
    3-hydroxyanthranilic acid dioxygenase
      Short name=HAD
    3-hydroxyanthranilate oxygenase
      Short name=3-HAO

Gene names

ORF Names:

K06A4.5

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	281 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity.
Catalytic activity	3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.
Cofactor	Fe2+ ion By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the 3-HAO family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-hydroxyanthranilate 3,4-dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 281	281	3-hydroxyanthranilate 3,4-dioxygenase		PRO_0000245470
Sites
	Metal binding	49	1	Iron; catalytic By similarity
	Metal binding	55	1	Iron; catalytic By similarity
	Metal binding	93	1	Iron; catalytic By similarity
	Binding site	45	1	Dioxygen By similarity
	Binding site	55	1	Substrate By similarity
	Binding site	97	1	Substrate By similarity
	Binding site	107	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q19341-1 [UniParc]. Last modified November 1, 1998. Version 2. Checksum: E3DD76D60D5930A9	FASTA	281	32,227
	10 20 30 40 50 60 MSGVTAIEIP QWIQDNQEDF VPPVCNKCMF SDQLKVFYVG GPNQRKDFHL EEGEEFFFQR 70 80 90 100 110 120 KGDMVLKVIE KGQVRDLVIK QGEMFMLPAR VEHSPQRFSN SIGLVVERER KNTEFDCVRF 130 140 150 160 170 180 LVGSSNITLF ERWFYLTDVV KDLPPLIKEF YGSNEFKTGK PGKGTFACNA PYEARWTDLP 190 200 210 220 230 240 VPINRKEFIY DHISEVKNGP VRIYGAPEYK TEVMLLGEGS YDLESGTVEL LIWLQENTFA 250 260 270 280 VVEESGFTYA MKSETMVRIK PNTKCLLNVK GGFAITIRMP A

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z70751, Z70755 Genomic DNA. Translation: CAA94753.1. Z70755, Z70751 Genomic DNA. Translation: CAA94787.1.
PIR	T20743.
RefSeq	NP_505450.1.
UniGene	Cel.3124
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q19341. 3 interactions.
STRING	Q19341.
Genome annotation databases
Ensembl	K06A4.5; K06A4.5; K06A4.5; Caenorhabditis elegans. [Genome view]
GeneID	179329.
KEGG	cel:K06A4.5.
NMPDR	fig|6239.3.peg.19117.
UCSC	K06A4.5. c. elegans.
Organism-specific databases
CTD	179329.
WormBase	WBGene00010595. K06A4.5.
WormPep	K06A4.5. CE06109. [WorfDB]
Phylogenomic databases
OMA	IEIPQWI.
Enzyme and pathway databases
BRENDA	1.13.11.6. 672.
Gene expression databases
ArrayExpress	Q19341.
Family and domain databases
InterPro	IPR010329. 3hydroanth_dOase. IPR016700. 3hydroanth_dOase_met. [Graphical view]
Pfam	PF06052. 3-HAO. 1 hit. [Graphical view]
PIRSF	PIRSF017681. 3hydroanth_dOase_animal. 1 hit.
TIGRFAMs	TIGR03037. anthran_nbaC. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	904940.

Entry information

Entry name

3HAO_CAEEL

Accession

Primary (citable) accession number: Q19341
Secondary accession number(s): Q21258

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	November 1, 1998
Last modified:	November 3, 2009
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project