Reviewed,
UniProtKB/Swiss-Prot Q19341 (3HAO_CAEEL)
Last modified
November 3, 2009.
Version 70.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 3-hydroxyanthranilate 3,4-dioxygenase EC=1.13.11.6 Alternative name(s): 3-hydroxyanthranilic acid dioxygenase Short name=HAD 3-hydroxyanthranilate oxygenase Short name=3-HAO | ||
| Gene names |
| ||
| Organism | Caenorhabditis elegans [Complete proteome] | ||
| Taxonomic identifier | 6239 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 281 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity. |
| Catalytic activity | 3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. |
| Cofactor | Fe2+ ion By similarity. |
| Pathway | Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the 3-HAO family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Pyridine nucleotide biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | Iron Metal-binding |
| Molecular function | Dioxygenase Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyridine nucleotide biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 3-hydroxyanthranilate 3,4-dioxygenase activity Inferred from electronic annotation. Source: EC iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 281 | 281 | 3-hydroxyanthranilate 3,4-dioxygenase | PRO_0000245470 | |||||
Sites | |||||||||
| Metal binding | 49 | 1 | Iron; catalytic By similarity | ||||||
| Metal binding | 55 | 1 | Iron; catalytic By similarity | ||||||
| Metal binding | 93 | 1 | Iron; catalytic By similarity | ||||||
| Binding site | 45 | 1 | Dioxygen By similarity | ||||||
| Binding site | 55 | 1 | Substrate By similarity | ||||||
| Binding site | 97 | 1 | Substrate By similarity | ||||||
| Binding site | 107 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
Cross-references
Sequence databases | |
|---|---|
| Z70751, Z70755 Genomic DNA. Translation: CAA94753.1. Z70755, Z70751 Genomic DNA. Translation: CAA94787.1. | |
| PIR | T20743. |
| RefSeq | NP_505450.1. |
| UniGene | Cel.3124 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q19341. 3 interactions. |
| STRING | Q19341. |
Genome annotation databases | |
| Ensembl | K06A4.5; K06A4.5; K06A4.5; Caenorhabditis elegans. [Genome view] |
| GeneID | 179329. |
| KEGG | cel:K06A4.5. |
| NMPDR | fig|6239.3.peg.19117. |
| UCSC | K06A4.5. c. elegans. |
Organism-specific databases | |
| CTD | 179329. |
| WormBase | WBGene00010595. K06A4.5. |
| WormPep | K06A4.5. CE06109. [WorfDB] |
Phylogenomic databases | |
| OMA | IEIPQWI. |
Enzyme and pathway databases | |
| BRENDA | 1.13.11.6. 672. |
Gene expression databases | |
| ArrayExpress | Q19341. |
Family and domain databases | |
| InterPro | IPR010329. 3hydroanth_dOase. IPR016700. 3hydroanth_dOase_met. [Graphical view] |
| Pfam | PF06052. 3-HAO. 1 hit. [Graphical view] |
| PIRSF | PIRSF017681. 3hydroanth_dOase_animal. 1 hit. |
| TIGRFAMs | TIGR03037. anthran_nbaC. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 904940. |
Entry information
| Entry name | 3HAO_CAEEL | ||||||||
| Accession | Primary (citable) accession number: Q19341 Secondary accession number(s): Q21258 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


