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Q19341

- 3HAO_CAEEL

UniProt

Q19341 - 3HAO_CAEEL

Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

haao-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

    Catalytic activityi

    3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

    Cofactori

    Fe2+ ion.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei45 – 451DioxygenUniRule annotation
    Metal bindingi49 – 491Iron; catalyticUniRule annotation
    Metal bindingi55 – 551Iron; catalyticUniRule annotation
    Binding sitei55 – 551SubstrateUniRule annotation
    Metal bindingi93 – 931Iron; catalyticUniRule annotation
    Binding sitei97 – 971SubstrateUniRule annotation
    Binding sitei107 – 1071SubstrateUniRule annotation

    GO - Molecular functioni

    1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
    2. ferrous iron binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    4. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00330.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
    Alternative name(s):
    3-hydroxyanthranilate oxygenaseUniRule annotation
    Short name:
    3-HAOUniRule annotation
    3-hydroxyanthranilic acid dioxygenaseUniRule annotation
    Short name:
    HADUniRule annotation
    Gene namesi
    Name:haao-1
    ORF Names:K06A4.5
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiK06A4.5; CE06109; WBGene00010595; haao-1.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2812813-hydroxyanthranilate 3,4-dioxygenasePRO_0000245470Add
    BLAST

    Proteomic databases

    PaxDbiQ19341.
    PRIDEiQ19341.

    2D gel databases

    World-2DPAGE0011:Q19341.

    Interactioni

    Protein-protein interaction databases

    BioGridi44367. 2 interactions.
    IntActiQ19341. 5 interactions.
    MINTiMINT-116934.
    STRINGi6239.K06A4.5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ19341.
    SMRiQ19341. Positions 12-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 162162Domain A (catalytic)UniRule annotationAdd
    BLAST
    Regioni163 – 17917LinkerUniRule annotationAdd
    BLAST
    Regioni180 – 281102Domain BUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the 3-HAO family.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG77058.
    GeneTreeiENSGT00390000013008.
    HOGENOMiHOG000218448.
    InParanoidiQ19341.
    KOiK00452.
    OMAiDMCLKVI.
    OrthoDBiEOG7FFMS4.
    PhylomeDBiQ19341.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    HAMAPiMF_00825. 3_HAO.
    InterProiIPR010329. 3hydroanth_dOase.
    IPR016700. 3hydroanth_dOase_met.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR15497. PTHR15497. 1 hit.
    PfamiPF06052. 3-HAO. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017681. 3hydroanth_dOase_animal. 1 hit.
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q19341-1 [UniParc]FASTAAdd to Basket

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    MSGVTAIEIP QWIQDNQEDF VPPVCNKCMF SDQLKVFYVG GPNQRKDFHL    50
    EEGEEFFFQR KGDMVLKVIE KGQVRDLVIK QGEMFMLPAR VEHSPQRFSN 100
    SIGLVVERER KNTEFDCVRF LVGSSNITLF ERWFYLTDVV KDLPPLIKEF 150
    YGSNEFKTGK PGKGTFACNA PYEARWTDLP VPINRKEFIY DHISEVKNGP 200
    VRIYGAPEYK TEVMLLGEGS YDLESGTVEL LIWLQENTFA VVEESGFTYA 250
    MKSETMVRIK PNTKCLLNVK GGFAITIRMP A 281
    Length:281
    Mass (Da):32,227
    Last modified:November 1, 1998 - v2
    Checksum:iE3DD76D60D5930A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z70755, Z70751 Genomic DNA. Translation: CAA94787.1.
    PIRiT20743.
    RefSeqiNP_505450.1. NM_073049.1.
    UniGeneiCel.3124.

    Genome annotation databases

    EnsemblMetazoaiK06A4.5; K06A4.5; WBGene00010595.
    GeneIDi179329.
    KEGGicel:CELE_K06A4.5.
    UCSCiK06A4.5. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z70755 , Z70751 Genomic DNA. Translation: CAA94787.1 .
    PIRi T20743.
    RefSeqi NP_505450.1. NM_073049.1.
    UniGenei Cel.3124.

    3D structure databases

    ProteinModelPortali Q19341.
    SMRi Q19341. Positions 12-241.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 44367. 2 interactions.
    IntActi Q19341. 5 interactions.
    MINTi MINT-116934.
    STRINGi 6239.K06A4.5.

    2D gel databases

    World-2DPAGE 0011:Q19341.

    Proteomic databases

    PaxDbi Q19341.
    PRIDEi Q19341.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai K06A4.5 ; K06A4.5 ; WBGene00010595 .
    GeneIDi 179329.
    KEGGi cel:CELE_K06A4.5.
    UCSCi K06A4.5. c. elegans.

    Organism-specific databases

    CTDi 179329.
    WormBasei K06A4.5 ; CE06109 ; WBGene00010595 ; haao-1.

    Phylogenomic databases

    eggNOGi NOG77058.
    GeneTreei ENSGT00390000013008.
    HOGENOMi HOG000218448.
    InParanoidi Q19341.
    KOi K00452.
    OMAi DMCLKVI.
    OrthoDBi EOG7FFMS4.
    PhylomeDBi Q19341.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00330 .

    Miscellaneous databases

    NextBioi 904940.
    PROi Q19341.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    HAMAPi MF_00825. 3_HAO.
    InterProi IPR010329. 3hydroanth_dOase.
    IPR016700. 3hydroanth_dOase_met.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR15497. PTHR15497. 1 hit.
    Pfami PF06052. 3-HAO. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017681. 3hydroanth_dOase_animal. 1 hit.
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry namei3HAO_CAEEL
    AccessioniPrimary (citable) accession number: Q19341
    Secondary accession number(s): Q21258
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3