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Protein

Cadherin-4

Gene

cdh-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potential calcium-dependent cell-adhesion protein that controls axon guidance in the ventral cord.2 Publications

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: WormBase
  • establishment or maintenance of cell polarity Source: WormBase
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • neuroblast migration Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-4
Gene namesi
Name:cdh-4
ORF Names:F25F2.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF25F2.2a; CE43309; WBGene00000396; cdh-4.
F25F2.2b; CE43926; WBGene00000396; cdh-4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 40364013ExtracellularSequence analysisAdd
BLAST
Transmembranei4037 – 405721HelicalSequence analysisAdd
BLAST
Topological domaini4058 – 4292235CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 42924269Cadherin-4PRO_0000250582Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence analysis
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence analysis
Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence analysis
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence analysis
Glycosylationi339 – 3391N-linked (GlcNAc...)Sequence analysis
Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence analysis
Glycosylationi431 – 4311N-linked (GlcNAc...)Sequence analysis
Glycosylationi452 – 4521N-linked (GlcNAc...)Sequence analysis
Glycosylationi584 – 5841N-linked (GlcNAc...)Sequence analysis
Glycosylationi811 – 8111N-linked (GlcNAc...)Sequence analysis
Glycosylationi899 – 8991N-linked (GlcNAc...)Sequence analysis
Glycosylationi1192 – 11921N-linked (GlcNAc...)1 Publication
Glycosylationi1335 – 13351N-linked (GlcNAc...)Sequence analysis
Glycosylationi1610 – 16101N-linked (GlcNAc...)Sequence analysis
Glycosylationi1895 – 18951N-linked (GlcNAc...)Sequence analysis
Glycosylationi2059 – 20591N-linked (GlcNAc...)Sequence analysis
Glycosylationi2150 – 21501N-linked (GlcNAc...)Sequence analysis
Glycosylationi2216 – 22161N-linked (GlcNAc...)Sequence analysis
Glycosylationi2367 – 23671N-linked (GlcNAc...)Sequence analysis
Glycosylationi2377 – 23771N-linked (GlcNAc...)Sequence analysis
Glycosylationi2404 – 24041N-linked (GlcNAc...)Sequence analysis
Glycosylationi2499 – 24991N-linked (GlcNAc...)Sequence analysis
Glycosylationi2808 – 28081N-linked (GlcNAc...)Sequence analysis
Glycosylationi2880 – 28801N-linked (GlcNAc...)2 Publications
Glycosylationi2905 – 29051N-linked (GlcNAc...)Sequence analysis
Glycosylationi3047 – 30471N-linked (GlcNAc...)Sequence analysis
Glycosylationi3107 – 31071N-linked (GlcNAc...)Sequence analysis
Glycosylationi3294 – 32941N-linked (GlcNAc...)Sequence analysis
Glycosylationi3476 – 34761N-linked (GlcNAc...)Sequence analysis
Disulfide bondi3674 ↔ 3685By similarity
Disulfide bondi3679 ↔ 3696By similarity
Glycosylationi3691 – 36911N-linked (GlcNAc...)Sequence analysis
Disulfide bondi3698 ↔ 3707By similarity
Disulfide bondi3862 ↔ 3889By similarity
Disulfide bondi3897 ↔ 3908By similarity
Disulfide bondi3902 ↔ 3918By similarity
Disulfide bondi3920 ↔ 3929By similarity
Disulfide bondi3936 ↔ 3947By similarity
Disulfide bondi3941 ↔ 3956By similarity
Disulfide bondi3958 ↔ 3967By similarity
Glycosylationi4007 – 40071N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ19319.
PaxDbiQ19319.

Expressioni

Tissue specificityi

In larvae and adult, it is expressed in various tissues including pharyngeal muscle, hypodermis and gonad. In the nervous system it is expressed in sensory neurons and motor neurons in the ventral cord.1 Publication

Interactioni

Protein-protein interaction databases

IntActiQ19319. 1 interaction.
STRINGi6239.F25F2.2a.

Structurei

3D structure databases

ProteinModelPortaliQ19319.
SMRiQ19319. Positions 388-2060, 2065-3453, 3655-3709, 3728-4011.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 153108Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini156 – 275120Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini384 – 492109Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini493 – 608116Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini609 – 720112Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini721 – 826106Cadherin 6PROSITE-ProRule annotationAdd
BLAST
Domaini827 – 934108Cadherin 7PROSITE-ProRule annotationAdd
BLAST
Domaini935 – 1051117Cadherin 8PROSITE-ProRule annotationAdd
BLAST
Domaini1047 – 1156110Cadherin 9PROSITE-ProRule annotationAdd
BLAST
Domaini1155 – 1262108Cadherin 10PROSITE-ProRule annotationAdd
BLAST
Domaini1265 – 136399Cadherin 11PROSITE-ProRule annotationAdd
BLAST
Domaini1364 – 1467104Cadherin 12PROSITE-ProRule annotationAdd
BLAST
Domaini1468 – 1570103Cadherin 13PROSITE-ProRule annotationAdd
BLAST
Domaini1671 – 1784114Cadherin 14PROSITE-ProRule annotationAdd
BLAST
Domaini1881 – 1984104Cadherin 15PROSITE-ProRule annotationAdd
BLAST
Domaini2082 – 2186105Cadherin 16PROSITE-ProRule annotationAdd
BLAST
Domaini2187 – 228599Cadherin 17PROSITE-ProRule annotationAdd
BLAST
Domaini2286 – 2469184Cadherin 18PROSITE-ProRule annotationAdd
BLAST
Domaini2470 – 2572103Cadherin 19PROSITE-ProRule annotationAdd
BLAST
Domaini2573 – 2676104Cadherin 20PROSITE-ProRule annotationAdd
BLAST
Domaini2677 – 2777101Cadherin 21PROSITE-ProRule annotationAdd
BLAST
Domaini2776 – 2879104Cadherin 22PROSITE-ProRule annotationAdd
BLAST
Domaini2877 – 297599Cadherin 23PROSITE-ProRule annotationAdd
BLAST
Domaini2976 – 3077102Cadherin 24PROSITE-ProRule annotationAdd
BLAST
Domaini3078 – 3180103Cadherin 25PROSITE-ProRule annotationAdd
BLAST
Domaini3181 – 3290110Cadherin 26PROSITE-ProRule annotationAdd
BLAST
Domaini3291 – 3392102Cadherin 27PROSITE-ProRule annotationAdd
BLAST
Domaini3393 – 3518126Cadherin 28PROSITE-ProRule annotationAdd
BLAST
Domaini3670 – 370839EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini3721 – 3889169Laminin G-likePROSITE-ProRule annotationAdd
BLAST
Domaini3893 – 393038EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini3932 – 396837EGF-like 3PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1090 – 10923Cell attachment siteSequence analysis
Motifi4171 – 41733Cell attachment siteSequence analysis

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 28 cadherin domains.PROSITE-ProRule annotation
Contains 3 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1219. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
HOGENOMiHOG000021369.
InParanoidiQ19319.
KOiK16506.
OMAiCLRGECR.
OrthoDBiEOG7WMCHJ.
PhylomeDBiQ19319.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.60. 29 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00028. Cadherin. 15 hits.
PF00008. EGF. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 28 hits.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 27 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS00232. CADHERIN_1. 9 hits.
PS50268. CADHERIN_2. 27 hits.
PS00022. EGF_1. 4 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q19319-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKHRVFHLF LLIFCKAISL VTTSSSTEQI FEFTAPLYNL SVEENSIGSK
60 70 80 90 100
YARSENSTKI GVPLPEKDAN CKFRVAEIVG EKSSLFKAHS RQVGDFVFLR
110 120 130 140 150
IRYKGDNPLN RELKDFYDIL VKAMCKRRDL SNLETTARIH LRVIDRNDAS
160 170 180 190 200
PVFLVGEQGY EAEIDDDLEP FSTVLRVEAS DADIGINSAI YFSLVNRSHD
210 220 230 240 250
FIVEPVTGWV RSLRHVKPGK YSLKVKSEDR ASRLYYFDEN EVQPSWTADV
260 270 280 290 300
LITVRETKPK PRRILVDQRK INPNILNNRQ LAAIITLKDS PNDAIVGLKG
310 320 330 340 350
NEKEHWFEVE PEVVGNDGTK ELRWMLYAKN GSQVPKNTNV TLTIGEDYIR
360 370 380 390 400
RSGFSISKKP VIPTNETVTI QIERLAEHLI RFLDNEKLTL KTDEMAPIGR
410 420 430 440 450
ILYRMNVNVE NPDDVSLIRY SLEYSKSDLP NATLPFAIGS KNGILRVSAK
460 470 480 490 500
INRSERVYNF KVIASLHGIN EKLAEKDVSI EILDSNDHAP VFSAKWMRQT
510 520 530 540 550
PIVIGKPGDV LVKVDATDQD EGENGKIVYK FTSELPLEIN ANTGEITLVE
560 570 580 590 600
VPKKGNSWPA TVWAIDLGLP LSRMSALNLM FYKNGTKIPA KPKPIIIQES
610 620 630 640 650
ENKHSPVFSS FPEIVEVTED APIGTVVAKL QANDEDTGYN GFIRYVIHDI
660 670 680 690 700
AGSSHEVLTV DEQSGEITVA SDLSKLMKEK LEVLDVQLKV SAIDAGTPVK
710 720 730 740 750
SSVKTMKLRI KDVNNHSPQF DEVSYYLRIS ENEKPGKDIF KVTANDFDGG
760 770 780 790 800
NNGKIKFSLG NNQEKSSVIS IDAKTGIVKL LKSLDREDQD VHTFAIIASD
810 820 830 840 850
EGFPMRVSVT NLTISVEDVN DNPPKCVVQH SRARIPEDLP HGAFVSCMAA
860 870 880 890 900
FDEDIGQNSK LKFLLNSEKV PFRIDHHSGC IFIHAPEYPL DYHKTPFFNL
910 920 930 940 950
SIEVADHGDP ILSTSCHLHV ELVDIAHNHL AIEFDDVAKE ASVYENSEIG
960 970 980 990 1000
TEVIMIEAKE TGDEQKVKAE NLEYRIIGGD GWPHFSIDQK GTVRTTHLLD
1010 1020 1030 1040 1050
RETKSAYWIT VEARDSKTDL YKDPRRRDVL HVFIRILDRN DHRPVAKKPM
1060 1070 1080 1090 1100
YIASVAENSP ANVVIVKVEA TDADDVDNDA AAPLMFKIER GDPQSFFRID
1110 1120 1130 1140 1150
LTSGYITTSG IRRLDREKQS EHELWVSICD GGEPQLCSNV IVIVNVLDEN
1160 1170 1180 1190 1200
DNSPTFTQAI HHYSVRSKFA GKLCRIFAVD ADEGENARLT YNITEGDARF
1210 1220 1230 1240 1250
SIDNNGNIIA SEAIHGDESY ALTVQATDHG TPGQQFAATR VVLTANSAGQ
1260 1270 1280 1290 1300
KPRKSKNSPP EISGKKSDYV IPISDADQVG LTVGKLEASD ADGDELWWSI
1310 1320 1330 1340 1350
SSGDPDSVFD VRQDTGQLLL AKKVELLKRG ELRLNISVTD GQAWDHSTVI
1360 1370 1380 1390 1400
IQVSRQISQR PKFSASHYQT DVSERVAVGT QIYTLKASGE SLGTKPLVFN
1410 1420 1430 1440 1450
LFSVDDVAME DKIRVEPSSG NVIVMEPLDY EAARRIRAVV QVQQANMKSF
1460 1470 1480 1490 1500
ATFSVNINDE NDNSPYFVGH TAFAFVDESD TVDDVLATVT AFDKDRGENG
1510 1520 1530 1540 1550
IVTYSIVSGN EESLFKIDAK SGEVRLAKPL DPELQHVESI LRIRAIDSAA
1560 1570 1580 1590 1600
NSLKDEMSLH IRNSNEAPET AKFDRKVYQT TLYDSTRPGT PVLVLNALHH
1610 1620 1630 1640 1650
GTVSYKLEPN CTFFEVHTLS GAVHLATWLT KLKHRKSVEC TAIVESTEGQ
1660 1670 1680 1690 1700
QDIAKVIAKI IRTNQHSPIF RRQVYRGTIR ENMPTGSSVL SKSLLPLVVS
1710 1720 1730 1740 1750
AIDEDPGSNG LVGYRMLSPK DEQMFSVDQY SGAIRTQMSF DFEKMKEYSF
1760 1770 1780 1790 1800
YVQAFDMGQP PRRSLMPSLI VVTVIDENDE PPRFPSNSLD ISMILPTANG
1810 1820 1830 1840 1850
VSVGGQTAQD MDSVGSLRYF IKDQSVPFSV DSKTGDVLVK DSNGISDMTK
1860 1870 1880 1890 1900
LFDLEVFVTD GKQSASYVMK ISTISTENSK FKFTRNEYHT SLIENTTLPP
1910 1920 1930 1940 1950
GSIILSVATI GDKLDHFSIV NPHEAFFIHP GTGVISSSGI ALDREKSAII
1960 1970 1980 1990 2000
RLVVQAKSHE KNPVMARALV VVGIENINDE TPIFMGTPYD ITIGHSDIGT
2010 2020 2030 2040 2050
VVLEPKVIDN DEGDVVTISS ENMPEYFKIV GGKVVLGKKL PSIEEEDLEF
2060 2070 2080 2090 2100
NFKLIAKDNG SVHRVEEPVK IRVVDKARPV FSQNVYTAVI SKESTKKSTV
2110 2120 2130 2140 2150
LVKVMAKSSL QSKSKGLIGY RILDKKSPFS VDFLTGEVRL NNLKMLAETN
2160 2170 2180 2190 2200
YTFEVEAREV TRPKMIAKAQ VEIIVKSGIT THAPVFEKLK YTASTPESTS
2210 2220 2230 2240 2250
IGQRLLTIKA TTSDENDTIE YSLSGSKDIE IHPETGDVTI TGQLDYEKTQ
2260 2270 2280 2290 2300
KYDLKLVATS SGKQVSSEAE FIVLIEDVND EMPEFIRSDV SAKISDSAIT
2310 2320 2330 2340 2350
GQFITIMSAT DMDTTNSLDE ESQKLLYKIV DGDETLFNIS PATGELSLAR
2360 2370 2380 2390 2400
PVEQDDLVNE DTKKVLNVSV TDGIIVNKSA LLTVAVKGGV PPLQFSLAPT
2410 2420 2430 2440 2450
TSSNSSTSKE AWPVAIDRKT GRIHVSRVLN YHRDKRYQIP LVVEDATGRR
2460 2470 2480 2490 2500
AFSTLTLSVI DINDKPPFFV LPFYSTSISE SAKEGDTVMM VSATDDDEND
2510 2520 2530 2540 2550
TIEYSLLDGS ESQFFSVHPR QGTITVAKKL EHKAGVTLSL TIKATDSANP
2560 2570 2580 2590 2600
PHHATTTVEV NIASESVKVP RFSNSHYLFS VMEDADVGNV IGRVQQMETE
2610 2620 2630 2640 2650
IDEIRFTIVP GSEESDSFLP FSVERSTGKI IVKSSLDRER KNQWKMTIRA
2660 2670 2680 2690 2700
DAAGGVHAIT TVTVDIGDVN DNAPAFHGDY ERFTISEDAA VGTSVTIFSA
2710 2720 2730 2740 2750
MDRDDSPSGR IRFSLVEENP YFDLNENSGW LTVASQLDRE KIDHYKLIAR
2760 2770 2780 2790 2800
ATDEGGFNTD LPFTIVVSDV NDSPPQFEKE EFNIDLHLPS TSPILHFSIK
2810 2820 2830 2840 2850
DDDLSPNNVS QFFIPKGNEE GVFWIDSNND LLLKRPEIVE NKMQYQLKVT
2860 2870 2880 2890 2900
AFDGVFETST KVKINLKSSK DSDIRCPEAN KTVILAENSK KGTVVLGESS
2910 2920 2930 2940 2950
LLGPNVTFKL SDNDGNVFVV NFRNGIVKVK ESDQIDYEKN QQLEFHRLTI
2960 2970 2980 2990 3000
QDNSEVCKEL ITVVIENLND NRPKIIEKLL KVSIDENLPT SEDARQYITR
3010 3020 3030 3040 3050
IVAEDADFDE IKFRMVDDFG GLFQIDDING VVTVVKPLDS EILGFFNLTV
3060 3070 3080 3090 3100
VASDGEFEDK ATILVTVIDQ NDNAPTFEKS TYSMKVMESE SIGYELAHFR
3110 3120 3130 3140 3150
ASGGDQNETI EYYLKPSDVT SFVNLNAQTG ILTLAKPLDF ETLSALKLTV
3160 3170 3180 3190 3200
VAKDSGVPPL ETEAQVEISV MDENDNAPKF EKEKYVGKVK ENSKSGEKVL
3210 3220 3230 3240 3250
TVKALDVDSE HFGAVSYELE IVSETTTDTP VLPFAINSNG DVLISQSIDY
3260 3270 3280 3290 3300
EKIKKYNLKV IAKDGGRPPL RSEALLEIHV EDENDHAPTF DDCNMTALVQ
3310 3320 3330 3340 3350
EGEAIGHRLL KFSVSDLDGP KNGAPFTVEI QGDGAKSFKV NEKLELLTAK
3360 3370 3380 3390 3400
KLEYRKKDKY LLTVIAKDVK GKTTDCPLTI FIRQTSRHAP TMKPMKIQIN
3410 3420 3430 3440 3450
TLQNELPEGI IGRLKASDED EEDQNGLLRF GLVEGSIQSP RAQVQESRST
3460 3470 3480 3490 3500
HLFRVDPNTG DIWSDHSITQ GLHTFNVTVT DSKFNTVSYV EVHVTSIDND
3510 3520 3530 3540 3550
VIDHAVSIRI RSMSVDEFMR KHVKEFRRII SHHLNLNDDS SIQLISVQAV
3560 3570 3580 3590 3600
PSTESERRSR RNSMEDVEIL MTAQRGLGRG YLKPDHIYSR LKNDFQNMND
3610 3620 3630 3640 3650
QSQRMRYQLI TEMCTTGVCL RGECREVIEL IEDSWTKVST DDFSFVSPFH
3660 3670 3680 3690 3700
SRSAQCLCPD GFGGKRCEVE TNQCAKSPCE QWQLCIPSVH NSTYECVCPL
3710 3720 3730 3740 3750
GMEGDKCSVP SCQNDGKCLE EAELSVGGDG YFEISLSNEI ETRMELEIEL
3760 3770 3780 3790 3800
KTTTHNGIIM WSRGKRDFHM LRLVNGTPEY HWNAGTGTGI VTSKTSVVDG
3810 3820 3830 3840 3850
QWHRIAISRR QRRTRMTVDD EDLQEAFSPI GSTVINLHRY SQKLVLGAKV
3860 3870 3880 3890 3900
DDGELTDGVS ACFRTISVDG MKVLKTRQGM KLFGAQPGCS ALTSSPCNDL
3910 3920 3930 3940 3950
PCQHAGTCIS QGKSHFKCEC PSRYSGNVCE IDLEPCASSP CPTGIQCIPF
3960 3970 3980 3990 4000
YNDYLCKCPN GFTGKHCEAR GFEDHETSSC SKNVCGTSGQ CISIPRHSLE
4010 4020 4030 4040 4050
SSDFICNCTG GILQSTPCAE KSDILSTVLE FLLKAEIVIV ILGVLLLLLV
4060 4070 4080 4090 4100
FCLTFITWKC CKKNRDPKYG AHCDVPHMRN TRVLVPVVPP PLPPRGFRND
4110 4120 4130 4140 4150
SSNFISTSSV TTSHRPMVQV KPYSSDIRDS RSPSACGSSK GTRRDPLPSD
4160 4170 4180 4190 4200
KFRRVDETAN RIRHSDRKDP RGDVLSSLRD SSDEWMGIDD RIDSSLKYSR
4210 4220 4230 4240 4250
AAAGTVIVGD TELMPVINDN DYMTMKPRKD KNFEREKPPA IPAHATPLES
4260 4270 4280 4290
VLKLGSSSSG EEAPRNALYD DPISLDSQTF DDIDEEVNIH IS
Note: No experimental confirmation available.
Length:4,292
Mass (Da):477,199
Last modified:September 22, 2009 - v3
Checksum:i61467BF69740D0AA
GO
Isoform b (identifier: Q19319-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2354: Missing.
     2355-2374: DDLVNEDTKKVLNVSVTDGI → MQPPPRFEQSHYVANALENT

Note: No experimental confirmation available.
Show »
Length:1,938
Mass (Da):215,627
Checksum:i7A7341DED197D569
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 23542354Missing in isoform b. CuratedVSP_053228Add
BLAST
Alternative sequencei2355 – 237420DDLVN…VTDGI → MQPPPRFEQSHYVANALENT in isoform b. CuratedVSP_053229Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35599, Z34802, Z35662 Genomic DNA. Translation: CAA84661.2.
Z35599, Z34802, Z35662 Genomic DNA. Translation: CAZ65488.1.
PIRiT20721.
RefSeqiNP_001254917.1. NM_001267988.1. [Q19319-1]
NP_001254918.1. NM_001267989.1. [Q19319-2]
UniGeneiCel.10567.

Genome annotation databases

EnsemblMetazoaiF25F2.2a; F25F2.2a; WBGene00000396. [Q19319-1]
GeneIDi175590.
KEGGicel:CELE_F25F2.2.
UCSCiF25F2.2. c. elegans. [Q19319-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35599, Z34802, Z35662 Genomic DNA. Translation: CAA84661.2.
Z35599, Z34802, Z35662 Genomic DNA. Translation: CAZ65488.1.
PIRiT20721.
RefSeqiNP_001254917.1. NM_001267988.1. [Q19319-1]
NP_001254918.1. NM_001267989.1. [Q19319-2]
UniGeneiCel.10567.

3D structure databases

ProteinModelPortaliQ19319.
SMRiQ19319. Positions 388-2060, 2065-3453, 3655-3709, 3728-4011.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ19319. 1 interaction.
STRINGi6239.F25F2.2a.

Proteomic databases

EPDiQ19319.
PaxDbiQ19319.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF25F2.2a; F25F2.2a; WBGene00000396. [Q19319-1]
GeneIDi175590.
KEGGicel:CELE_F25F2.2.
UCSCiF25F2.2. c. elegans. [Q19319-1]

Organism-specific databases

CTDi175590.
WormBaseiF25F2.2a; CE43309; WBGene00000396; cdh-4.
F25F2.2b; CE43926; WBGene00000396; cdh-4.

Phylogenomic databases

eggNOGiKOG1219. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
HOGENOMiHOG000021369.
InParanoidiQ19319.
KOiK16506.
OMAiCLRGECR.
OrthoDBiEOG7WMCHJ.
PhylomeDBiQ19319.

Miscellaneous databases

PROiQ19319.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.60. 29 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00028. Cadherin. 15 hits.
PF00008. EGF. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 28 hits.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 27 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS00232. CADHERIN_1. 9 hits.
PS50268. CADHERIN_2. 27 hits.
PS00022. EGF_1. 4 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.
  2. "Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins."
    Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J., Kasai K., Takahashi N., Isobe T.
    Nat. Biotechnol. 21:667-672(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2880, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.
  3. "The fat-like cadherin CDH-4 controls axon guidance in the ventral cord of C. elegans."
    Schmitz C., Wacker I., Schwarz V., Hutter H.
    (In) Proceedings of the 15th international C. elegans meeting, pp.288-288, Los Angeles (2005)
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  4. "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
    Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
    Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1192 AND ASN-2880, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.
  5. "Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126)."
    Schmitz C., Kinge P., Hutter H.
    Proc. Natl. Acad. Sci. U.S.A. 104:834-839(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCADH4_CAEEL
AccessioniPrimary (citable) accession number: Q19319
Secondary accession number(s): G5EE05, Q19785, Q21606
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: September 22, 2009
Last modified: May 11, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.