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Protein

Putative neurobeachin homolog

Gene

sel-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). Regulates endosomal traffic in polarized epithelial cells such as the vulval precursor cells and intestinal cells. Thought to act as a negative regulator of lin-12 activity in vulval precursor cells. May have a role in the internalization process from basolateral surface of polarized epithelial cells.By similarity1 Publication

GO - Biological processi

  • apical protein localization Source: WormBase
  • endosomal transport Source: WormBase
  • negative regulation of Notch signaling pathway Source: WormBase
  • positive regulation of endocytosis Source: WormBase
  • regulation of vulval development Source: WormBase
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ19317.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative neurobeachin homolog
Alternative name(s):
Suppressor enhancer of lin-12
Gene namesi
Name:sel-2
ORF Names:F10F2.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF10F2.1; CE32621; WBGene00004760; sel-2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: WormBase
  • membrane Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB-SubCell
  • perinuclear region of cytoplasm Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Worms lacking sel-2 exhibit a multivulva phenotype when combined with loss of lin-12.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 25072507Putative neurobeachin homologPRO_0000051092Add
BLAST

Proteomic databases

PaxDbiQ19317.
PRIDEiQ19317.

PTM databases

iPTMnetiQ19317.

Expressioni

Tissue specificityi

Expressed in vulval precursor cells and rectal epithelia in L2 and L3 larvae. In L4 larvae, expression is seen in intestinal epithelial cells.1 Publication

Gene expression databases

BgeeiWBGene00004760.

Interactioni

Subunit structurei

Interacts with RII subunit of PKA.By similarity

Protein-protein interaction databases

STRINGi6239.F10F2.1.

Structurei

3D structure databases

ProteinModelPortaliQ19317.
SMRiQ19317. Positions 1697-2106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1690 – 1798109BEACH-type PHPROSITE-ProRule annotationAdd
BLAST
Domaini1817 – 2106290BEACHPROSITE-ProRule annotationCuratedAdd
BLAST
Repeati2265 – 230844WD 1CuratedAdd
BLAST
Repeati2326 – 236540WD 2CuratedAdd
BLAST
Repeati2405 – 244440WD 3CuratedAdd
BLAST
Repeati2447 – 248640WD 4CuratedAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat neurobeachin family.Curated
Contains 1 BEACH domain.PROSITE-ProRule annotationCurated
Contains 1 BEACH-type PH domain.PROSITE-ProRule annotation
Contains 4 WD repeats.PROSITE-ProRule annotationCurated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1786. Eukaryota.
ENOG410XNQC. LUCA.
GeneTreeiENSGT00760000119083.
HOGENOMiHOG000082375.
InParanoidiQ19317.
OMAiQTPPCHY.
OrthoDBiEOG091G024D.
PhylomeDBiQ19317.

Family and domain databases

CDDicd06071. Beach. 1 hit.
Gene3Di1.10.1540.10. 1 hit.
1.25.10.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.40. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000409. BEACH_dom.
IPR013320. ConA-like_dom.
IPR010508. DUF1088.
IPR031570. DUF4704.
IPR023362. PH-BEACH_dom.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF02138. Beach. 1 hit.
PF06469. DUF1088. 1 hit.
PF15787. DUF4704. 1 hit.
PF14844. PH_BEACH. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM01026. Beach. 1 hit.
SM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF49899. SSF49899. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEiPS50197. BEACH. 1 hit.
PS51783. PH_BEACH. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q19317-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEISETSHNE SGPPVQENGI VEIPVEEGEE VNDEESNMET VDLGLDDSAA
60 70 80 90 100
DASSPSVFKN IDDEAPGDPS DAAKKEEDSE EIVVPSVLAP TPSQEVSPPN
110 120 130 140 150
AIESLPPLPE GKELELEDDV TSSLPRLLSK TTLIHSNEEG ADETIQRLVT
160 170 180 190 200
VLHSNSPNTD RTQVVDNLFN LLVGGHFDQE SKFVIEDAAN VDHMLTLLSH
210 220 230 240 250
CDYDLQNEIW SLFLAVMKKS NRNLEACTRV GLISKVLDIL PEAPPLLADL
260 270 280 290 300
LVQIIAALVA YSINVKQTKH LLRALKSTKE QWPPNSLKLL HVLKEMPQHD
310 320 330 340 350
SADVFFSFPG KDQSGIILPP IKTMPYQQGW TFATWLRMEP LNSVTFEKEQ
360 370 380 390 400
PVLYSFRTSK GVGYSCHFTG NCLVVNVEKT KGKEQSRCVR AELGARKWHH
410 420 430 440 450
IAIAHCYSRW GRSDIKCFID GQLAETIELS WVVTSATNWD RCSIGVSADG
460 470 480 490 500
TANSAFCGQM GAMYLFAEAL TLQQANSLFC LGPVYQSTFK HDSETSLPEG
510 520 530 540 550
YKKHLFDGHL HSSLVFAYCP KNCHGQLCLY TPPKTAASTY FVQIPHAVMK
560 570 580 590 600
EGVEVITTHS IHKSLQSVGG IQILLPLFAQ IDLPSSNDNS IDGEVCQTLL
610 620 630 640 650
SLIALLLSSS QSSQQQLFHS KGFLIISSCL QKASPSHLSM KVLEQLIHIA
660 670 680 690 700
KFLLRCPAGG PLLKHLFDYI LFNPKLWIRA RPEVQVHLYQ YLATDFLANN
710 720 730 740 750
NFSQMLRRVP TVIEMCHTLK HFYWLALPQT VSDYTIEERP ENFATADIVA
760 770 780 790 800
IRSSILTFIN RIIIASAGPE EEERVRDQEV HTLLNLLATV REDDNLYDVL
810 820 830 840 850
ALVTRLLAEH PAIMIPAIDK NKALGIIFNL LAAPNELIRI PALKILGFFL
860 870 880 890 900
SRSTLKRKTE SMGNQNLFSL IGERLLSHKK VLSLPTYNVL LEILVEQMTP
910 920 930 940 950
TFTYACHQPA QPEWKFENPH LLKVIAHVIS QCEESENIVQ IKKCFLIDII
960 970 980 990 1000
NLCRESKENR RTILQMSVWQ DWLIGLAYVF HTTESQNEVS ELVWEAFSIL
1010 1020 1030 1040 1050
LHHALRNEYG GWRVWVDTLA IAHSKVSFEK FKRKLAEAKI KAERSESGGE
1060 1070 1080 1090 1100
EAKMEPTPIY RAPEFAWSDV HVRLLADLLS GIERVVDEWK VAECGISDQC
1110 1120 1130 1140 1150
NASENQVFVG NVVHVVSQLS DSLIMACGGL LPLLASATAP NNDMEIVDPC
1160 1170 1180 1190 1200
QQQLPISVSA GFLMRFARLV DTFVLASGVS FSELEQEKNM PAGGVLRQSL
1210 1220 1230 1240 1250
RISATVTVRH ILASRIQQPD TPRYETNSTK KNQCIMEFVR EALEKRSPDG
1260 1270 1280 1290 1300
LENVERLVQD SDITRIKGVV YRDMVEENRQ AQFLALSVIY LVSVLMVSRY
1310 1320 1330 1340 1350
RDILEPPSSP SPFFDSTTQK QENSENVNSE TSPENGSNGK LANGGDNLSI
1360 1370 1380 1390 1400
KNGIESNGND GEEEENGEEG QGDDGGRIAA IKVANADMKR GDGNEYDEEE
1410 1420 1430 1440 1450
LSKMHQSNGR RPSTMMPVQQ TAERRAYLTT KLQTALETCA PLLREMMSDF
1460 1470 1480 1490 1500
RGYLQKTLLG THGQEIMNDT KVLETLRNRN ASVIELVMLL CSQEWQTSLQ
1510 1520 1530 1540 1550
KHAGLAFIEL VNEGRLMAHA TRDHVLRVAN EADFILNRLR AEDVSKHAQF
1560 1570 1580 1590 1600
EAESREQLAA RHEEYGRCDL LIASGRLRDS INATRLLEKM SAILSDQDDS
1610 1620 1630 1640 1650
KSGTQFWKLD VWEDDSRRRK RFVPNAYGSR HEEANLPEGE KNEEPEISEQ
1660 1670 1680 1690 1700
EKIRKVLKGL FSKRQNSSGS HELVDESDID KWAQEVDPTP SSQSACFSTT
1710 1720 1730 1740 1750
AKLIAPGVVV PGTLSVTAND LFFDANESDP NYKKQCAQVL RYCEALHARW
1760 1770 1780 1790 1800
NLQEIRAIFL RRYLLQNTAL ELFLASRTAI MFAFDSEDAV KKVVYQLPRV
1810 1820 1830 1840 1850
GVGVKYGLPQ SRKTSLMTPR QLFKHSDMCA KWQKREISNF DYLMFLNTVA
1860 1870 1880 1890 1900
GRTFNDLSQY PVFPWILTNY TSDTLDLSVA SNFRDLSKPI GALSEARRKF
1910 1920 1930 1940 1950
FNDRYTSWDD DQVPAFHYGT HYSTPAFTLN WLLRVEPFAS MFINLHDGKF
1960 1970 1980 1990 2000
DHPDRITHSI KDSWDRCQRD SHDVKELIPE LFYLPEMFRN SSKFNLGRRA
2010 2020 2030 2040 2050
DGTPVDDVVL PPWAESPEHF VLMHRQALES DLVSCQLNQW IDLIFGYKQR
2060 2070 2080 2090 2100
GAEAVRATNV FYHLTYEGTV TPKMAETPGQ VAAIEQQILS FGQTPSQLLT
2110 2120 2130 2140 2150
EAHPPRHSIM SMAPTMFRRH DEDLCMMMKY ISNSPVVYLA ANTFHQLPQP
2160 2170 2180 2190 2200
TVVGVAQNLV FSLNKWDNSY SYGASQRSAL SMDPSNAEGQ VSLPLTADAQ
2210 2220 2230 2240 2250
LASAASTTPV ARRHLGDAFD QRLTVQCSNF VTTTDSKFIF ACGYPDYSFR
2260 2270 2280 2290 2300
IVDTDSGRVR QAVYGHGDVV TCIARSETSL FSDCYVVTGS MDCTVVLWHW
2310 2320 2330 2340 2350
NGTTGFIAGE YNQPGEVPSP RSILTGHEAS ISALCVSAEH GLVVSGCEDG
2360 2370 2380 2390 2400
VILIHTTSSD LLRRIRGHGI VTQLSMSREC ILLSLFDSKR MVTYSATAKK
2410 2420 2430 2440 2450
LDEVLVDDKI ECVTVTRDGE FAVTGAVNGR INIWRMFPLT KLYTYQPLNS
2460 2470 2480 2490 2500
AVRSVAVVAS HRFILGGLDS GAIVVFNADF NRWHYEYKHR YIQNTSAAKP

VQQSPQK
Length:2,507
Mass (Da):281,205
Last modified:June 20, 2003 - v3
Checksum:iD2084909EFCE1C9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35598, Z46242 Genomic DNA. Translation: CCO25913.1.
PIRiT20719.
RefSeqiNP_497939.2. NM_065538.5.
UniGeneiCel.10609.

Genome annotation databases

EnsemblMetazoaiF10F2.1; F10F2.1; WBGene00004760.
GeneIDi175606.
KEGGicel:CELE_F10F2.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35598, Z46242 Genomic DNA. Translation: CCO25913.1.
PIRiT20719.
RefSeqiNP_497939.2. NM_065538.5.
UniGeneiCel.10609.

3D structure databases

ProteinModelPortaliQ19317.
SMRiQ19317. Positions 1697-2106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F10F2.1.

PTM databases

iPTMnetiQ19317.

Proteomic databases

PaxDbiQ19317.
PRIDEiQ19317.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF10F2.1; F10F2.1; WBGene00004760.
GeneIDi175606.
KEGGicel:CELE_F10F2.1.

Organism-specific databases

CTDi175606.
WormBaseiF10F2.1; CE32621; WBGene00004760; sel-2.

Phylogenomic databases

eggNOGiKOG1786. Eukaryota.
ENOG410XNQC. LUCA.
GeneTreeiENSGT00760000119083.
HOGENOMiHOG000082375.
InParanoidiQ19317.
OMAiQTPPCHY.
OrthoDBiEOG091G024D.
PhylomeDBiQ19317.

Enzyme and pathway databases

SignaLinkiQ19317.

Miscellaneous databases

PROiQ19317.

Gene expression databases

BgeeiWBGene00004760.

Family and domain databases

CDDicd06071. Beach. 1 hit.
Gene3Di1.10.1540.10. 1 hit.
1.25.10.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.40. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000409. BEACH_dom.
IPR013320. ConA-like_dom.
IPR010508. DUF1088.
IPR031570. DUF4704.
IPR023362. PH-BEACH_dom.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF02138. Beach. 1 hit.
PF06469. DUF1088. 1 hit.
PF15787. DUF4704. 1 hit.
PF14844. PH_BEACH. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM01026. Beach. 1 hit.
SM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF49899. SSF49899. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEiPS50197. BEACH. 1 hit.
PS51783. PH_BEACH. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNBEA_CAEEL
AccessioniPrimary (citable) accession number: Q19317
Secondary accession number(s): K8ESP0, Q20061
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 20, 2003
Last modified: September 7, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.