Q19264 (DEOC_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative deoxyribose-phosphate aldolase
Short name=DERA
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase

Gene names

ORF Names:

F09E5.3

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity.
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.

Ontologies

Keywords
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Putative deoxyribose-phosphate aldolase		PRO_0000057312
Sites
	Active site	220	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	256	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q19264 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 5921EA28AB7FEE0E	FASTA	303	33,087
	10 20 30 40 50 60 MATIVPTLFS FVRDTYKGRF DVATFEREVG RDFDNQEIAQ AISKYEQEAK NLRNKDEIRK 70 80 90 100 110 120 VIQYIDLTTL NGDDTASKVV ALAKRAINPV PTDPSIHCGS VCVYPQRIAD VKKFLASSKL 130 140 150 160 170 180 NSNITSVAGG FPSGQYHLKS KVLEVELSVA DGATEIDIVI SRASALDEDW KTVHDEVLAC 190 200 210 220 230 240 KKACGSAHLK TILATGELKT LSNVYRASWA SILAGSDFIK TSTGKESVNA TLEVAYVMCT 250 260 270 280 290 300 AIKRWHELTG KKVGFKPAGG IKTVDEALSY VALVKDILGD EWLNPHLFRI GASSLLDDCL KGL

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO081044 Genomic DNA. Translation: CCD68756.1.
PIR	T16004.
RefSeq	NP_495009.1. NM_062608.4.
UniGene	Cel.15479.
3D structure databases
ProteinModelPortal	Q19264.
SMR	Q19264. Positions 55-303.
ModBase	Search...
Protein-protein interaction databases
STRING	Q19264.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F09E5.3.1; F09E5.3.1; F09E5.3. F09E5.3.2; F09E5.3.2; F09E5.3.
GeneID	173911.
KEGG	cel:F09E5.3.
UCSC	F09E5.3.1. c. elegans.
Organism-specific databases
CTD	173911.
WormBase	F09E5.3; CE02610; WBGene00017283.
Phylogenomic databases
eggNOG	meNOG06049.
GeneTree	EMGT00050000016768.
HOGENOM	HBG636421.
InParanoid	Q19264.
OMA	DTPGKVR.
PhylomeDB	Q19264.
Gene expression databases
ArrayExpress	Q19264.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...
Other
NextBio	881635.

Entry information

Entry name

DEOC_CAEEL

Accession

Primary (citable) accession number: Q19264

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project