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Protein

3-hydroxy-3-methylglutaryl coenzyme A reductase

Gene

hmgr-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.UniRule annotationSAAS annotation

Pathwayi: (R)-mevalonate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes (R)-mevalonate from acetyl-CoA.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Hydroxymethylglutaryl-CoA synthase (hmgs-1)
  3. 3-hydroxy-3-methylglutaryl coenzyme A reductase (hmgr-1)
This subpathway is part of the pathway (R)-mevalonate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-mevalonate from acetyl-CoA, the pathway (R)-mevalonate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
LigandNADPUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00058; UER00103.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxy-3-methylglutaryl coenzyme A reductaseUniRule annotation (EC:1.1.1.34UniRule annotation)
Short name:
HMG-CoA reductaseUniRule annotation
Gene namesi
Name:hmgr-1Imported
ORF Names:CELE_F08F8.2Imported, F08F8.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF08F8.2; CE30649; WBGene00017268; hmgr-1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation

PTM / Processingi

Proteomic databases

EPDiQ19207.
PaxDbiQ19207.
PeptideAtlasiQ19207.

Expressioni

Gene expression databases

BgeeiWBGene00017268.

Interactioni

Protein-protein interaction databases

DIPiDIP-25409N.
IntActiQ19207. 4 interactors.
MINTiMINT-1101626.
STRINGi6239.F08F8.2.

Structurei

3D structure databases

ProteinModelPortaliQ19207.
SMRiQ19207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMG-CoA reductase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2480. Eukaryota.
COG1257. LUCA.
GeneTreeiENSGT00840000131602.
HOGENOMiHOG000050844.
InParanoidiQ19207.
KOiK00021.
OMAiYGFNAHF.
OrthoDBiEOG091G0I1B.
PhylomeDBiQ19207.

Family and domain databases

CDDicd00643. HMG-CoA_reductase_classI. 1 hit.
Gene3Di1.10.3270.10. 1 hit.
3.30.70.420. 1 hit.
3.90.770.10. 1 hit.
InterProiView protein in InterPro
IPR002202. HMG_CoA_Rdtase.
IPR023074. HMG_CoA_Rdtase_cat.
IPR023076. HMG_CoA_Rdtase_CS.
IPR004554. HMG_CoA_Rdtase_eu_arc.
IPR023282. HMG_CoA_Rdtase_N.
IPR009023. HMG_CoA_Rdtase_NAD(P)-bd_dom.
IPR009029. HMG_CoA_Rdtase_sub-bd_dom.
PANTHERiPTHR10572. PTHR10572. 1 hit.
PfamiView protein in Pfam
PF00368. HMG-CoA_red. 1 hit.
PRINTSiPR00071. HMGCOARDTASE.
SUPFAMiSSF55035. SSF55035. 1 hit.
SSF56542. SSF56542. 2 hits.
TIGRFAMsiTIGR00533. HMG_CoA_R_NADP. 1 hit.
PROSITEiView protein in PROSITE
PS00066. HMG_COA_REDUCTASE_1. 1 hit.
PS00318. HMG_COA_REDUCTASE_2. 1 hit.
PS50065. HMG_COA_REDUCTASE_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Q19207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVADKRKLLD FLQSCDISDE ASRKIENFIC ENYDQKEKPK RKPLFSVGED
60 70 80 90 100
DDSEEYVSPI KETCETGTQC KRDVEYPEIE SGNRSLDEIS REWKECKDVT
110 120 130 140 150
PGEAVRLLRR GQAKSRELES RFPAEQAIPI RRTFINKKFE NLPYLGYDYT
160 170 180 190 200
LATECCCENV IGYTPVPVGV AGPLTLNGTS EIYVPMATTE GALIASTNRG
210 220 230 240 250
MNVIRAAGGV ETSIFNSGMT RAPVVKFPTA RDAVSMKRWL EHPENQDRAR
260 270 280 290 300
QEFQSCSRFA KLKSIDITID GNLAYLRFDA HTGDAMGMNM ISKSCDSTMR
310 320 330 340 350
FLMENFPEMT VLALSGNLCV DKKAAAKNWT EGRGRSVVAE CLIPREVVTK
360 370 380 390 400
TLRTTPEQLA YLTTTKLHIG SSRAGAVGGS NAHAANIVAA IFIATGQDAA
410 420 430 440 450
QVVSSSMCST RMEVTADKNL YVSCTLPCVE VGTVGGGTIL APQRACLESL
460 470 480 490 500
GCAGPNKEQP GQNAERLAEV IAATVLAGEL SLMAALTTNE LVSSHMKLNR
510 520 530 540 550
SKQQLYADDS GKATHFEKEV EKAGSLLSGK SGNIKLKRLP QDVVQCSNIL
Length:550
Mass (Da):60,089
Last modified:June 1, 2002 - v2
Checksum:iFDAECFEC14546AA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CCD69058.1.
PIRiT15979.
RefSeqiNP_498626.2. NM_066225.5.
UniGeneiCel.5083.

Genome annotation databases

EnsemblMetazoaiF08F8.2; F08F8.2; WBGene00017268.
GeneIDi176047.
KEGGicel:CELE_F08F8.2.
UCSCiF08F8.2. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiQ19207_CAEEL
AccessioniPrimary (citable) accession number: Q19207
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: June 1, 2002
Last modified: September 27, 2017
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported