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Protein

3-hydroxy-3-methylglutaryl coenzyme A reductase

Gene

hmgr-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.UniRule annotationSAAS annotation

Pathwayi: (R)-mevalonate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes (R)-mevalonate from acetyl-CoA.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Hydroxymethylglutaryl-CoA synthase (hmgs-1)
  3. 3-hydroxy-3-methylglutaryl coenzyme A reductase (hmgr-1)
This subpathway is part of the pathway (R)-mevalonate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-mevalonate from acetyl-CoA, the pathway (R)-mevalonate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Ligandi

NADPUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-CEL-191273. Cholesterol biosynthesis.
UniPathwayiUPA00058; UER00103.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxy-3-methylglutaryl coenzyme A reductaseUniRule annotation (EC:1.1.1.34UniRule annotation)
Short name:
HMG-CoA reductaseUniRule annotation
Gene namesi
Name:hmgr-1Imported
ORF Names:CELE_F08F8.2Imported, F08F8.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF08F8.2; CE30649; WBGene00017268; hmgr-1.

Subcellular locationi

  • Endoplasmic reticulum membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation

PTM / Processingi

Proteomic databases

EPDiQ19207.
PaxDbiQ19207.
PRIDEiQ19207.

Expressioni

Gene expression databases

BgeeiWBGene00017268.

Interactioni

Protein-protein interaction databases

DIPiDIP-25409N.
IntActiQ19207. 3 interactions.
MINTiMINT-1101626.
STRINGi6239.F08F8.2.

Structurei

3D structure databases

ProteinModelPortaliQ19207.
SMRiQ19207. Positions 125-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMG-CoA reductase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2480. Eukaryota.
COG1257. LUCA.
GeneTreeiENSGT00840000131602.
HOGENOMiHOG000050844.
InParanoidiQ19207.
KOiK00021.
OMAiCSTRMEV.
OrthoDBiEOG091G0I1B.
PhylomeDBiQ19207.

Family and domain databases

CDDicd00643. HMG-CoA_reductase_classI. 1 hit.
Gene3Di1.10.3270.10. 1 hit.
3.30.70.420. 1 hit.
3.90.770.10. 2 hits.
InterProiIPR002202. HMG_CoA_Rdtase.
IPR023074. HMG_CoA_Rdtase_cat.
IPR023076. HMG_CoA_Rdtase_CS.
IPR004554. HMG_CoA_Rdtase_eu_arc.
IPR023282. HMG_CoA_Rdtase_N.
IPR009023. HMG_CoA_Rdtase_NAD(P)-bd_dom.
IPR009029. HMG_CoA_Rdtase_sub-bd_dom.
[Graphical view]
PANTHERiPTHR10572. PTHR10572. 1 hit.
PfamiPF00368. HMG-CoA_red. 1 hit.
[Graphical view]
PRINTSiPR00071. HMGCOARDTASE.
SUPFAMiSSF55035. SSF55035. 1 hit.
SSF56542. SSF56542. 2 hits.
TIGRFAMsiTIGR00533. HMG_CoA_R_NADP. 1 hit.
PROSITEiPS00066. HMG_COA_REDUCTASE_1. 1 hit.
PS00318. HMG_COA_REDUCTASE_2. 1 hit.
PS50065. HMG_COA_REDUCTASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q19207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVADKRKLLD FLQSCDISDE ASRKIENFIC ENYDQKEKPK RKPLFSVGED
60 70 80 90 100
DDSEEYVSPI KETCETGTQC KRDVEYPEIE SGNRSLDEIS REWKECKDVT
110 120 130 140 150
PGEAVRLLRR GQAKSRELES RFPAEQAIPI RRTFINKKFE NLPYLGYDYT
160 170 180 190 200
LATECCCENV IGYTPVPVGV AGPLTLNGTS EIYVPMATTE GALIASTNRG
210 220 230 240 250
MNVIRAAGGV ETSIFNSGMT RAPVVKFPTA RDAVSMKRWL EHPENQDRAR
260 270 280 290 300
QEFQSCSRFA KLKSIDITID GNLAYLRFDA HTGDAMGMNM ISKSCDSTMR
310 320 330 340 350
FLMENFPEMT VLALSGNLCV DKKAAAKNWT EGRGRSVVAE CLIPREVVTK
360 370 380 390 400
TLRTTPEQLA YLTTTKLHIG SSRAGAVGGS NAHAANIVAA IFIATGQDAA
410 420 430 440 450
QVVSSSMCST RMEVTADKNL YVSCTLPCVE VGTVGGGTIL APQRACLESL
460 470 480 490 500
GCAGPNKEQP GQNAERLAEV IAATVLAGEL SLMAALTTNE LVSSHMKLNR
510 520 530 540 550
SKQQLYADDS GKATHFEKEV EKAGSLLSGK SGNIKLKRLP QDVVQCSNIL
Length:550
Mass (Da):60,089
Last modified:June 1, 2002 - v2
Checksum:iFDAECFEC14546AA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CCD69058.1.
PIRiT15979.
RefSeqiNP_498626.2. NM_066225.5.
UniGeneiCel.5083.

Genome annotation databases

EnsemblMetazoaiF08F8.2; F08F8.2; WBGene00017268.
GeneIDi176047.
KEGGicel:CELE_F08F8.2.
UCSCiF08F8.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CCD69058.1.
PIRiT15979.
RefSeqiNP_498626.2. NM_066225.5.
UniGeneiCel.5083.

3D structure databases

ProteinModelPortaliQ19207.
SMRiQ19207. Positions 125-501.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-25409N.
IntActiQ19207. 3 interactions.
MINTiMINT-1101626.
STRINGi6239.F08F8.2.

Proteomic databases

EPDiQ19207.
PaxDbiQ19207.
PRIDEiQ19207.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF08F8.2; F08F8.2; WBGene00017268.
GeneIDi176047.
KEGGicel:CELE_F08F8.2.
UCSCiF08F8.2. c. elegans.

Organism-specific databases

CTDi176047.
WormBaseiF08F8.2; CE30649; WBGene00017268; hmgr-1.

Phylogenomic databases

eggNOGiKOG2480. Eukaryota.
COG1257. LUCA.
GeneTreeiENSGT00840000131602.
HOGENOMiHOG000050844.
InParanoidiQ19207.
KOiK00021.
OMAiCSTRMEV.
OrthoDBiEOG091G0I1B.
PhylomeDBiQ19207.

Enzyme and pathway databases

UniPathwayiUPA00058; UER00103.
ReactomeiR-CEL-191273. Cholesterol biosynthesis.

Miscellaneous databases

PROiQ19207.

Gene expression databases

BgeeiWBGene00017268.

Family and domain databases

CDDicd00643. HMG-CoA_reductase_classI. 1 hit.
Gene3Di1.10.3270.10. 1 hit.
3.30.70.420. 1 hit.
3.90.770.10. 2 hits.
InterProiIPR002202. HMG_CoA_Rdtase.
IPR023074. HMG_CoA_Rdtase_cat.
IPR023076. HMG_CoA_Rdtase_CS.
IPR004554. HMG_CoA_Rdtase_eu_arc.
IPR023282. HMG_CoA_Rdtase_N.
IPR009023. HMG_CoA_Rdtase_NAD(P)-bd_dom.
IPR009029. HMG_CoA_Rdtase_sub-bd_dom.
[Graphical view]
PANTHERiPTHR10572. PTHR10572. 1 hit.
PfamiPF00368. HMG-CoA_red. 1 hit.
[Graphical view]
PRINTSiPR00071. HMGCOARDTASE.
SUPFAMiSSF55035. SSF55035. 1 hit.
SSF56542. SSF56542. 2 hits.
TIGRFAMsiTIGR00533. HMG_CoA_R_NADP. 1 hit.
PROSITEiPS00066. HMG_COA_REDUCTASE_1. 1 hit.
PS00318. HMG_COA_REDUCTASE_2. 1 hit.
PS50065. HMG_COA_REDUCTASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ19207_CAEEL
AccessioniPrimary (citable) accession number: Q19207
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.