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Protein

Zinc finger protein unc-98

Gene

unc-98

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcription factor required for muscle structure (PubMed:12808046, PubMed:7348600). Its dual subcellular localization suggests that it may function both as a muscle adhesion complex protein and as a transcription factor, or work together with transcription factors, to influence gene expression (PubMed:12808046). Thought to act as a molecular bridge between unc-97 and myo-3 at the M-line of muscles, possibly in a signaling role (PubMed:17158957). Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord (PubMed:27123983).4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri113 – 135C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri141 – 163C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 188C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST20
Zinc fingeri246 – 268C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • cytoskeletal protein binding Source: WormBase
  • DNA binding Source: UniProtKB-KW
  • myosin binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • locomotion Source: UniProtKB
  • locomotory behavior Source: UniProtKB
  • muscle organ development Source: UniProtKB-KW
  • myofibril assembly Source: UniProtKB
  • post-embryonic body morphogenesis Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Muscle protein
Biological processDifferentiation, Myogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein unc-98
Alternative name(s):
Uncoordinated protein 98
Gene namesi
Name:unc-98
ORF Names:F08C6.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF08C6.7; CE31900; WBGene00006827; unc-98.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Thick filament

Pathology & Biotechi

Disruption phenotypei

Disorganised A and I bands in body-wall muscle structure (PubMed:7348600). Defective extension of body wall muscle connections or arms towards the ventral nerve cord (PubMed:27123983). Double knockout with madd-3 results in severe muscle arm extension defects (PubMed:27123983).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000468961 – 310Zinc finger protein unc-98Add BLAST310

Proteomic databases

EPDiQ19203.
PaxDbiQ19203.
PeptideAtlasiQ19203.
PRIDEiQ19203.

Expressioni

Tissue specificityi

Expressed in embryos from 1.5- to 2-fold stage in myofibrils. In larvae and adults, it is expressed in body wall muscle, and in addition, anal depressor muscle and vulval muscles. More specifically it is found in the thick filaments of muscle fibers.2 Publications

Gene expression databases

BgeeiWBGene00006827.

Interactioni

Subunit structurei

Interacts with hum-6, mep-1, myo-3, unc-96 and unc-97/PINCH.3 Publications

GO - Molecular functioni

  • cytoskeletal protein binding Source: WormBase
  • myosin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi45944. 2 interactors.
DIPiDIP-25572N.
IntActiQ19203. 50 interactors.
MINTiMINT-115012.
STRINGi6239.F08C6.7.

Structurei

3D structure databases

ProteinModelPortaliQ19203.
SMRiQ19203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni198 – 310Interaction with myo-3Add BLAST113

Domaini

The N-terminal part (1-106) mediates the nuclear localization, while the fourth zinc finger is required for the localization to M-lines and dense bodies.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri113 – 135C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri141 – 163C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 188C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST20
Zinc fingeri246 – 268C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000140347.
HOGENOMiHOG000154785.
InParanoidiQ19203.
OMAiAHERIHD.
OrthoDBiEOG091G0CE8.
PhylomeDBiQ19203.

Family and domain databases

InterProiView protein in InterPro
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 3 hits.
SUPFAMiSSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Q19203-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDDIFKEAR KERDDFEELM NACDLAKMSV KNNEMVHGLE TFGINGESSE
60 70 80 90 100
NGNKEKPKEI MKVVAPTVEA YVGSSSAQTP TKSSGGALDG SDQQEVRQDG
110 120 130 140 150
TSVQKDDNGF VFYKCRFCGL TFNFMNTLRA HERIHDVSQP YVCGKCGDSF
160 170 180 190 200
EFACQLEYHA AQHSEIDGYK CECGRTFFSY TEMLYHKHTD DPLELIGAPE
210 220 230 240 250
TTTIKVSKKR VLPVSEQDLP QPAFVTEGYE PKHPLRVYND VRSKPYICEY
260 270 280 290 300
CSKSYSDSRG LAYHMYSHRG EKYFNPRASR YMMGREGVGY TDSRSYYLFP
310
RTSGYVTPRF
Length:310
Mass (Da):35,353
Last modified:March 1, 2003 - v2
Checksum:iF052E8CD0BA3AAB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF515600 mRNA. Translation: AAM76039.1.
FO080866 Genomic DNA. Translation: CCD67350.1.
PIRiT15974.
RefSeqiNP_509284.2. NM_076883.6.
UniGeneiCel.9298.

Genome annotation databases

EnsemblMetazoaiF08C6.7; F08C6.7; WBGene00006827.
GeneIDi181020.
KEGGicel:CELE_F08C6.7.
UCSCiF08C6.7. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiUNC98_CAEEL
AccessioniPrimary (citable) accession number: Q19203
Secondary accession number(s): Q8MUP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase