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Protein

60S ribosomal protein L11-2

Gene

rpl-11.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.By similarity

Miscellaneous

There's a functional difference between the two L11-encoding proteins in C.elegans. rpl-11.1 plays a role in the germline whereas rpl-11.2 has a somatic function.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-CEL-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-CEL-72689. Formation of a pool of free 40S subunits.
R-CEL-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-CEL-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-CEL-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L11-2Curated
Gene namesi
Name:rpl-11.2Imported
ORF Names:F07D10.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF07D10.1; CE07033; WBGene00004423; rpl-11.2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown results in a growth defect.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004369031 – 19660S ribosomal protein L11-2CuratedAdd BLAST196

Proteomic databases

EPDiQ19162.
PaxDbiQ19162.
PeptideAtlasiQ19162.

Expressioni

Gene expression databases

BgeeiWBGene00004423.

Interactioni

Subunit structurei

Component of the large ribosomal subunit.By similarity

Protein-protein interaction databases

DIPiDIP-26065N.
IntActiQ19162. 3 interactors.
MINTiMINT-1118628.
STRINGi6239.F07D10.1.2.

Structurei

3D structure databases

ProteinModelPortaliQ19162.
SMRiQ19162.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the universal ribosomal protein uL5 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0397. Eukaryota.
COG0094. LUCA.
GeneTreeiENSGT00390000013411.
HOGENOMiHOG000231312.
InParanoidiQ19162.
KOiK02868.
OMAiEDTMAWF.
OrthoDBiEOG091G0LSV.
PhylomeDBiQ19162.

Family and domain databases

Gene3Di3.30.1440.10. 1 hit.
InterProiView protein in InterPro
IPR002132. Ribosomal_L5.
IPR031309. Ribosomal_L5_C.
IPR020929. Ribosomal_L5_CS.
IPR022803. Ribosomal_L5_domain.
IPR031310. Ribosomal_L5_N.
PfamiView protein in Pfam
PF00281. Ribosomal_L5. 1 hit.
PF00673. Ribosomal_L5_C. 1 hit.
PIRSFiPIRSF002161. Ribosomal_L5. 1 hit.
SUPFAMiSSF55282. SSF55282. 1 hit.
PROSITEiView protein in PROSITE
PS00358. RIBOSOMAL_L5. 1 hit.

Sequencei

Sequence statusi: Complete.

Q19162-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDIEKQTEI REKKARNVMR ELKIQKLCLN ICVGESGDRL TRAAKVLEQL
60 70 80 90 100
TGQTPVFSKA RYTVRTFGIR RNEKIAVHCT VRGPKAEEIL EKGLKVKEYE
110 120 130 140 150
LYKENFSDTG NFGFGVQEHI DLGIKYDPSI GIYGMDFYVV LDRAGRRIAK
160 170 180 190
RRRAPGRVGP SHRVEREESI KWFQQKYDGI ILPPKPKVKR TFHRRR
Length:196
Mass (Da):22,776
Last modified:November 1, 1996 - v1
Checksum:iA5B397B6254FBD92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD61193.1.
PIRiT29860.
RefSeqiNP_508413.1. NM_076012.5.
UniGeneiCel.38559.

Genome annotation databases

EnsemblMetazoaiF07D10.1; F07D10.1; WBGene00004423.
GeneIDi180535.
KEGGicel:CELE_F07D10.1.
UCSCiF07D10.1.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiRL112_CAEEL
AccessioniPrimary (citable) accession number: Q19162
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 6, 2016
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families