Q19157 (PIN2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
LIM domain-containing protein pin-2

Gene names

Name:	pin-2
ORF Names:	F07C6.1

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cytoplasm. Nucleus Ref.2.
Tissue specificity	Expressed in neurons and intestine. Ref.2
Sequence similarities	Contains 5 LIM zinc-binding domains.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Domain	LIM domain Repeat
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay Ref.2. Source: WormBase nucleus Inferred from direct assay Ref.2. Source: WormBase varicosity Inferred from direct assay Ref.2. Source: WormBase
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform a (identifier: Q19157-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform b (identifier: Q19157-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-274: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	LIM domain-containing protein pin-2		PRO_0000075887
Regions
	Domain	21 – 73	53	LIM zinc-binding 1
	Domain	82 – 132	51	LIM zinc-binding 2
	Domain	144 – 194	51	LIM zinc-binding 3
	Domain	202 – 255	54	LIM zinc-binding 4
	Domain	264 – 315	52	LIM zinc-binding 5
Natural variations
	Alternative sequence	1 – 274	274	Missing in isoform b.		VSP_044155

Sequences

	Sequence		Length	Mass (Da)
	Isoform a [UniParc]. Last modified October 3, 2012. Version 2. Checksum: E3F4637BB75122ED	FASTA	330	38,741
	10 20 30 40 50 60 MMTNAAQITK QRNSGKRHRA CERCREQFEL NEPYFLLGAS SWHMRCFLCA QCMDPLVGTT 70 80 90 100 110 120 YFQFENRIYC EHDFKTLYAP VCAKCNEFVI GQVVHSSNNS YHLACFTCDE CNVHLNSQIA 130 140 150 160 170 180 YRYQGTILCF LCNQKKPKMR IYNCNKCKQH VDNSDLLTYQ ENPYHAYHFK CTTCKKVLES 190 200 210 220 230 240 DARTIKDDLF CPRCFDFKCE VCFDCKKVID PQVEQSIFTM NKHWHTDHFR CATCARPFFG 250 260 270 280 290 300 HEHYEKNGKA YCRDDFLELI GHHCFICDRN VGGGMVHVFG KAFCPECYRC RGCDKVLHYK 310 320 330 DKVMELDLMP LCKKCLGNKT FQKALKYKSL
	Isoform b [UniParc]. Checksum: E5BFE08B01ED16DF	FASTA	56	6,560
	10 20 30 40 50 MVHVFGKAFC PECYRCRGCD KVLHYKDKVM ELDLMPLCKK CLGNKTFQKA LKYKSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Bristol N2.
[2]	"A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans." Hobert O., Moerman D.G., Clark K.A., Beckerle M.C., Ruvkun G. J. Cell Biol. 144:45-57(1999) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z69659 Genomic DNA. Translation: CCG28057.1. Z69659 Genomic DNA. Translation: CCG28058.1.
PIR	T20546.
RefSeq	NP_001255672.1. NM_001268743.1. NP_001255673.1. NM_001268744.1.
3D structure databases
ProteinModelPortal	Q19157.
SMR	Q19157. Positions 21-129, 142-196, 201-261.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F07C6.1; F07C6.1; F07C6.1.
GeneID	178234.
KEGG	cel:CELE_F07C6.1.
UCSC	F07C6.1. c. elegans.
Organism-specific databases
CTD	178234.
WormBase	F07C6.1a; CE47311; WBGene00004030; pin-2. F07C6.1b; CE47192; WBGene00004030; pin-2.
Phylogenomic databases
eggNOG	NOG254940.
GeneTree	ENSGT00690000101670.
HOGENOM	HOG000253950.
InParanoid	Q19157.
Family and domain databases
Gene3D	2.10.110.10. 5 hits.
InterPro	IPR017351. PINCH. IPR001781. Znf_LIM. [Graphical view]
Pfam	PF00412. LIM. 4 hits. [Graphical view]
PIRSF	PIRSF038003. PINCH. 1 hit.
SMART	SM00132. LIM. 5 hits. [Graphical view]
PROSITE	PS00478. LIM_DOMAIN_1. 4 hits. PS50023. LIM_DOMAIN_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	900288.

Entry information

Entry name

PIN2_CAEEL

Accession

Primary (citable) accession number: Q19157
Secondary accession number(s): H9G2V0, H9G2V1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	October 3, 2012
Last modified:	May 1, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project