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Q19013 (GLS2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative glutaminase 2

Short name=GLS
EC=3.5.1.2
Alternative name(s):
L-glutamine amidohydrolase
Gene names
Name:glna-2
ORF Names:DH11.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length605 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamine + H2O = L-glutamate + NH3. HAMAP-Rule MF_00313

Sequence similarities

Belongs to the glutaminase family.

Contains 2 ANK repeats.

Ontologies

Keywords
   DomainANK repeat
Repeat
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutamine metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutaminase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 605605Putative glutaminase 2 HAMAP-Rule MF_00313
PRO_0000110584

Regions

Repeat480 – 50930ANK 1 HAMAP-Rule MF_00313
Repeat513 – 54331ANK 2 HAMAP-Rule MF_00313

Sites

Binding site2131Substrate By similarity
Binding site2621Substrate By similarity
Binding site3081Substrate By similarity
Binding site3151Substrate By similarity
Binding site3421Substrate By similarity
Binding site3941Substrate By similarity
Binding site4121Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q19013 [UniParc].

Last modified December 19, 2001. Version 2.
Checksum: CFBD8149DA535279

FASTA60568,336
        10         20         30         40         50         60 
MTSKPTTQKS VMYRIPSERT LESLHEMIGS RMSKMSLKNT LRGISNPYER DENEGSEDMI 

        70         80         90        100        110        120 
FELFKIPNKN EASIGKLLTV LRQLGLRDDD PRLVPMMEKI KDFEKIAEEK CSEATEQKHW 

       130        140        150        160        170        180 
KLTKEQFKEC IAPSIDIVSR ALQTDMVIPN WVTFVDQIRT LFNECKEIRE GQVATYIPQL 

       190        200        210        220        230        240 
ARQSPNLWAV SLCTVDGQRA SFGDVKHPFC VQSVSKAFNY AIVASDLGAD VVHSYVGQEP 

       250        260        270        280        290        300 
SGRLFNEICL DSTNKPHNPM VNSGAIVITS LIKSKTNMAD RFDFVLNQYR KIAGNEFIGF 

       310        320        330        340        350        360 
NNATFLSERA TADRNYALSY FMKENRCFPK ETESLTDALD FYFQLCSVEV TCESLAVMAS 

       370        380        390        400        410        420 
TLANGGVCPI TNETCVDPNP CRDVLSLMYS CGMYDASGQF SFNVGLPAKS GVSGAMIVVV 

       430        440        450        460        470        480 
PNVMGICLFS PPLDSLGNSC RGVAFCKKLV STFNFHNYDC LVHNSNIKSD PRRRDIRERD 

       490        500        510        520        530        540 
RLIPVFHVAR AGDLPTMRRL YMQGEDLNTS DHDDRTVLHI AATEGYETMI KFLVNVAKVD 

       550        560        570        580        590        600 
VDKKDRWGRT PLDEAKFFKH DHVSRFLEKA MKRPEQHRKD SVSSLDTDDE IDDDGFPEKP 


SFTID 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z49126 Genomic DNA. Translation: CAA88938.2.
PIRT20384.
RefSeqNP_495675.1. NM_063274.3.
UniGeneCel.8367.

3D structure databases

ProteinModelPortalQ19013.
SMRQ19013. Positions 57-584.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-59881N.
STRING6239.DH11.1.2.

Proteomic databases

PaxDbQ19013.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaDH11.1.1; DH11.1.1; DH11.1.
DH11.1.2; DH11.1.2; DH11.1.
GeneID174282.
KEGGcel:CELE_DH11.1.
UCSCDH11.1.1. c. elegans.

Organism-specific databases

CTD174282.
WormBaseDH11.1; CE28902; WBGene00008435; glna-2.

Phylogenomic databases

eggNOGCOG2066.
HOGENOMHOG000216891.
InParanoidQ19013.
KOK01425.
OMAQCCSMEA.
OrthoDBEOG7S4X5F.
PhylomeDBQ19013.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
3.40.710.10. 1 hit.
HAMAPMF_00313. Glutaminase.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERPTHR12544. PTHR12544. 1 hit.
PfamPF00023. Ank. 1 hit.
PF04960. Glutaminase. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsTIGR03814. Gln_ase. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio883355.

Entry information

Entry nameGLS2_CAEEL
AccessionPrimary (citable) accession number: Q19013
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 19, 2001
Last modified: April 16, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase