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Protein

Putative glutaminase 2

Gene

glna-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei213 – 2131SubstrateBy similarity
Binding sitei262 – 2621SubstrateBy similarity
Binding sitei308 – 3081SubstrateBy similarity
Binding sitei315 – 3151SubstrateBy similarity
Binding sitei342 – 3421SubstrateBy similarity
Binding sitei394 – 3941SubstrateBy similarity
Binding sitei412 – 4121Substrate; via amide nitrogenBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiREACT_285804. Amino acid synthesis and interconversion (transamination).
REACT_322471. Glutamate Neurotransmitter Release Cycle.
REACT_359390. TP53 Regulates Metabolic Genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glutaminase 2 (EC:3.5.1.2)
Short name:
GLS
Alternative name(s):
L-glutamine amidohydrolase
Gene namesi
Name:glna-2
ORF Names:DH11.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiDH11.1; CE28902; WBGene00008435; glna-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 605605Putative glutaminase 2PRO_0000110584Add
BLAST

Proteomic databases

PaxDbiQ19013.

Interactioni

Protein-protein interaction databases

DIPiDIP-59881N.
STRINGi6239.DH11.1.1.

Structurei

3D structure databases

ProteinModelPortaliQ19013.
SMRiQ19013. Positions 57-473, 484-570.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati480 – 50930ANK 1Add
BLAST
Repeati513 – 54331ANK 2Add
BLAST

Sequence similaritiesi

Belongs to the glutaminase family.Curated
Contains 2 ANK repeats.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG2066.
GeneTreeiENSGT00390000010463.
HOGENOMiHOG000216891.
InParanoidiQ19013.
KOiK01425.
OMAiFCAHIDE.
OrthoDBiEOG7S4X5F.
PhylomeDBiQ19013.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF00023. Ank. 1 hit.
PF04960. Glutaminase. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q19013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKPTTQKS VMYRIPSERT LESLHEMIGS RMSKMSLKNT LRGISNPYER
60 70 80 90 100
DENEGSEDMI FELFKIPNKN EASIGKLLTV LRQLGLRDDD PRLVPMMEKI
110 120 130 140 150
KDFEKIAEEK CSEATEQKHW KLTKEQFKEC IAPSIDIVSR ALQTDMVIPN
160 170 180 190 200
WVTFVDQIRT LFNECKEIRE GQVATYIPQL ARQSPNLWAV SLCTVDGQRA
210 220 230 240 250
SFGDVKHPFC VQSVSKAFNY AIVASDLGAD VVHSYVGQEP SGRLFNEICL
260 270 280 290 300
DSTNKPHNPM VNSGAIVITS LIKSKTNMAD RFDFVLNQYR KIAGNEFIGF
310 320 330 340 350
NNATFLSERA TADRNYALSY FMKENRCFPK ETESLTDALD FYFQLCSVEV
360 370 380 390 400
TCESLAVMAS TLANGGVCPI TNETCVDPNP CRDVLSLMYS CGMYDASGQF
410 420 430 440 450
SFNVGLPAKS GVSGAMIVVV PNVMGICLFS PPLDSLGNSC RGVAFCKKLV
460 470 480 490 500
STFNFHNYDC LVHNSNIKSD PRRRDIRERD RLIPVFHVAR AGDLPTMRRL
510 520 530 540 550
YMQGEDLNTS DHDDRTVLHI AATEGYETMI KFLVNVAKVD VDKKDRWGRT
560 570 580 590 600
PLDEAKFFKH DHVSRFLEKA MKRPEQHRKD SVSSLDTDDE IDDDGFPEKP

SFTID
Length:605
Mass (Da):68,336
Last modified:December 19, 2001 - v2
Checksum:iCFBD8149DA535279
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49126 Genomic DNA. Translation: CAA88938.2.
PIRiT20384.
RefSeqiNP_495675.1. NM_063274.3.
UniGeneiCel.8367.

Genome annotation databases

EnsemblMetazoaiDH11.1.1; DH11.1.1; WBGene00008435.
DH11.1.2; DH11.1.2; WBGene00008435.
GeneIDi174282.
KEGGicel:CELE_DH11.1.
UCSCiDH11.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49126 Genomic DNA. Translation: CAA88938.2.
PIRiT20384.
RefSeqiNP_495675.1. NM_063274.3.
UniGeneiCel.8367.

3D structure databases

ProteinModelPortaliQ19013.
SMRiQ19013. Positions 57-473, 484-570.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59881N.
STRINGi6239.DH11.1.1.

Proteomic databases

PaxDbiQ19013.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiDH11.1.1; DH11.1.1; WBGene00008435.
DH11.1.2; DH11.1.2; WBGene00008435.
GeneIDi174282.
KEGGicel:CELE_DH11.1.
UCSCiDH11.1.1. c. elegans.

Organism-specific databases

CTDi174282.
WormBaseiDH11.1; CE28902; WBGene00008435; glna-2.

Phylogenomic databases

eggNOGiCOG2066.
GeneTreeiENSGT00390000010463.
HOGENOMiHOG000216891.
InParanoidiQ19013.
KOiK01425.
OMAiFCAHIDE.
OrthoDBiEOG7S4X5F.
PhylomeDBiQ19013.

Enzyme and pathway databases

ReactomeiREACT_285804. Amino acid synthesis and interconversion (transamination).
REACT_322471. Glutamate Neurotransmitter Release Cycle.
REACT_359390. TP53 Regulates Metabolic Genes.

Miscellaneous databases

NextBioi883355.
PROiQ19013.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF00023. Ank. 1 hit.
PF04960. Glutaminase. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGLS2_CAEEL
AccessioniPrimary (citable) accession number: Q19013
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 19, 2001
Last modified: June 24, 2015
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.