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Q19013

- GLS2_CAEEL

UniProt

Q19013 - GLS2_CAEEL

Protein

Putative glutaminase 2

Gene

glna-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (19 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamine + H2O = L-glutamate + NH3.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei213 – 2131SubstrateBy similarity
    Binding sitei262 – 2621SubstrateBy similarity
    Binding sitei308 – 3081SubstrateBy similarity
    Binding sitei315 – 3151SubstrateBy similarity
    Binding sitei342 – 3421SubstrateBy similarity
    Binding sitei394 – 3941SubstrateBy similarity
    Binding sitei412 – 4121Substrate; via amide nitrogenBy similarity

    GO - Molecular functioni

    1. glutaminase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative glutaminase 2 (EC:3.5.1.2)
    Short name:
    GLS
    Alternative name(s):
    L-glutamine amidohydrolase
    Gene namesi
    Name:glna-2
    ORF Names:DH11.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiDH11.1; CE28902; WBGene00008435; glna-2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 605605Putative glutaminase 2PRO_0000110584Add
    BLAST

    Proteomic databases

    PaxDbiQ19013.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-59881N.
    STRINGi6239.DH11.1.2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ19013.
    SMRiQ19013. Positions 57-473, 484-570.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati480 – 50930ANK 1Add
    BLAST
    Repeati513 – 54331ANK 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the glutaminase family.Curated
    Contains 2 ANK repeats.Curated

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG2066.
    GeneTreeiENSGT00390000010463.
    HOGENOMiHOG000216891.
    InParanoidiQ19013.
    KOiK01425.
    OMAiQCCSMEA.
    OrthoDBiEOG7S4X5F.
    PhylomeDBiQ19013.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    3.40.710.10. 1 hit.
    HAMAPiMF_00313. Glutaminase.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view]
    PANTHERiPTHR12544. PTHR12544. 1 hit.
    PfamiPF00023. Ank. 1 hit.
    PF04960. Glutaminase. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 3 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q19013-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSKPTTQKS VMYRIPSERT LESLHEMIGS RMSKMSLKNT LRGISNPYER    50
    DENEGSEDMI FELFKIPNKN EASIGKLLTV LRQLGLRDDD PRLVPMMEKI 100
    KDFEKIAEEK CSEATEQKHW KLTKEQFKEC IAPSIDIVSR ALQTDMVIPN 150
    WVTFVDQIRT LFNECKEIRE GQVATYIPQL ARQSPNLWAV SLCTVDGQRA 200
    SFGDVKHPFC VQSVSKAFNY AIVASDLGAD VVHSYVGQEP SGRLFNEICL 250
    DSTNKPHNPM VNSGAIVITS LIKSKTNMAD RFDFVLNQYR KIAGNEFIGF 300
    NNATFLSERA TADRNYALSY FMKENRCFPK ETESLTDALD FYFQLCSVEV 350
    TCESLAVMAS TLANGGVCPI TNETCVDPNP CRDVLSLMYS CGMYDASGQF 400
    SFNVGLPAKS GVSGAMIVVV PNVMGICLFS PPLDSLGNSC RGVAFCKKLV 450
    STFNFHNYDC LVHNSNIKSD PRRRDIRERD RLIPVFHVAR AGDLPTMRRL 500
    YMQGEDLNTS DHDDRTVLHI AATEGYETMI KFLVNVAKVD VDKKDRWGRT 550
    PLDEAKFFKH DHVSRFLEKA MKRPEQHRKD SVSSLDTDDE IDDDGFPEKP 600
    SFTID 605
    Length:605
    Mass (Da):68,336
    Last modified:December 19, 2001 - v2
    Checksum:iCFBD8149DA535279
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49126 Genomic DNA. Translation: CAA88938.2.
    PIRiT20384.
    RefSeqiNP_495675.1. NM_063274.3.
    UniGeneiCel.8367.

    Genome annotation databases

    EnsemblMetazoaiDH11.1.1; DH11.1.1; WBGene00008435.
    DH11.1.2; DH11.1.2; WBGene00008435.
    GeneIDi174282.
    KEGGicel:CELE_DH11.1.
    UCSCiDH11.1.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49126 Genomic DNA. Translation: CAA88938.2 .
    PIRi T20384.
    RefSeqi NP_495675.1. NM_063274.3.
    UniGenei Cel.8367.

    3D structure databases

    ProteinModelPortali Q19013.
    SMRi Q19013. Positions 57-473, 484-570.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59881N.
    STRINGi 6239.DH11.1.2.

    Proteomic databases

    PaxDbi Q19013.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai DH11.1.1 ; DH11.1.1 ; WBGene00008435 .
    DH11.1.2 ; DH11.1.2 ; WBGene00008435 .
    GeneIDi 174282.
    KEGGi cel:CELE_DH11.1.
    UCSCi DH11.1.1. c. elegans.

    Organism-specific databases

    CTDi 174282.
    WormBasei DH11.1 ; CE28902 ; WBGene00008435 ; glna-2.

    Phylogenomic databases

    eggNOGi COG2066.
    GeneTreei ENSGT00390000010463.
    HOGENOMi HOG000216891.
    InParanoidi Q19013.
    KOi K01425.
    OMAi QCCSMEA.
    OrthoDBi EOG7S4X5F.
    PhylomeDBi Q19013.

    Miscellaneous databases

    NextBioi 883355.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    3.40.710.10. 1 hit.
    HAMAPi MF_00313. Glutaminase.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view ]
    PANTHERi PTHR12544. PTHR12544. 1 hit.
    Pfami PF00023. Ank. 1 hit.
    PF04960. Glutaminase. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiGLS2_CAEEL
    AccessioniPrimary (citable) accession number: Q19013
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: December 19, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3