Reviewed, UniProtKB/Swiss-Prot Q19000 (BODG_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable gamma-butyrobetaine dioxygenase
    EC=1.14.11.1
Alternative name(s):
    Gamma-butyrobetaine,2-oxoglutarate dioxygenase
    Gamma-butyrobetaine hydroxylase
      Short name=Gamma-BBH

Gene names

Name:	gbh-1
ORF Names:	D2089.5

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the formation of L-carnitine from gamma-butyrobetaine By similarity.
Catalytic activity	4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2.
Cofactor	Iron By similarity. Ascorbate By similarity.
Pathway	Amine and polyamine biosynthesis; carnitine biosynthesis.
Sequence similarities	Belongs to the gamma-BBH/TMLD family.

Ontologies

Keywords
Biological process	Carnitine biosynthesis
Ligand	Iron
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carnitine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	gamma-butyrobetaine dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 421	421	Probable gamma-butyrobetaine dioxygenase		PRO_0000207088

Sequences

	Sequence		Length	Mass (Da)
	Q19000-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 10949C4BF8262DF6	FASTA	421	48,436
	10 20 30 40 50 60 MLSALLIRNI RNASKLASVA GPNSDRIVNV KWSDGKTGVF PLIWLRDTSP DPSTYTISPA 70 80 90 100 110 120 MTARKLTMLE FDVEQNARKL WIDEDANCLK IEWESGVLSE FPSEWLKIRN PSDQEARRRR 130 140 150 160 170 180 RKVYLFPEQT WGKAEIEGKL KKFSHEEFMK NEQVVHDFLQ AVCIDGIAVL KGAPQGVRGA 190 200 210 220 230 240 VEAIGDRIGM IKRTHFGLVF EVSLKADASN MAYASNGGLP FHTDFPSLSH PPQLQMLHML 250 260 270 280 290 300 QSAEEGGHSL FVDGFHVAEQ LRVEKPEIFK ILTTQSMEYI EEGYDVHEIN GKTIRFDYDM 310 320 330 340 350 360 CARHKVIRLN DDGKVNKIQF GNAMRSWFYD CEPSKVQDVY RAMKTFTEYC YQPRNMLKFR 370 380 390 400 410 420 LEDGDTVLWA NQRLLHTRDG FRNAPEKART LTGCYFDWDI VKSRVRFLRD KLSLEQNQPS A

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z36948 Genomic DNA. Translation: CAA85412.1.
PIR	T20380.
RefSeq	NP_496305.1.
UniGene	Cel.14890
3D structure databases
SMR	Q19000. Positions 160-383.
ModBase	Search...
Protein-protein interaction databases
STRING	Q19000.
Genome annotation databases
Ensembl	D2089.5; D2089.5; D2089.5; Caenorhabditis elegans. [Genome view]
GeneID	174648.
KEGG	cel:D2089.5.
NMPDR	fig|6239.3.peg.7294.
UCSC	D2089.5. c. elegans.
Organism-specific databases
CTD	174648.
WormBase	WBGene00001522. gbh-1.
WormPep	D2089.5. CE00940. [WorfDB]
Phylogenomic databases
eggNOG	meNOG07549.
HOGENOM	HBG379537.
InParanoid	Q19000.
OMA	RELFLPX.
PhylomeDB	Q19000.
Enzyme and pathway databases
BRENDA	1.14.11.1. 672.
Gene expression databases
ArrayExpress	Q19000.
Family and domain databases
InterPro	IPR012775. 2-oxoglut_dOase. IPR003819. Taurine_dOase. [Graphical view]
Pfam	PF02668. TauD. 1 hit. [Graphical view]
TIGRFAMs	TIGR02409. carnitine_bodg. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	884906.

Entry information

Entry name

BODG_CAEEL

Accession

Primary (citable) accession number: Q19000

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project