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Protein

Protein Dok-7

Gene

DOK7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.1 Publication

GO - Molecular functioni

  • lipid binding Source: UniProtKB-KW
  • protein kinase binding Source: UniProtKB

GO - Biological processi

  • positive regulation of protein tyrosine kinase activity Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

SignaLinkiQ18PE1.
SIGNORiQ18PE1.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Dok-7
Alternative name(s):
Downstream of tyrosine kinase 7
Gene namesi
Name:DOK7
Synonyms:C4orf25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26594. DOK7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Myasthenic syndrome, congenital, 10 (CMS10)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS10 is an autosomal recessive, post-synaptic form characterized by a typical 'limb girdle' pattern of muscle weakness with small, simplified neuromuscular junctions but normal acetylcholine receptor and acetylcholinesterase function.
See also OMIM:254300
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0687503E → K in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant rs763233743dbSNPEnsembl.1
Natural variantiVAR_06875131P → T in CMS10; results in a significant reduction of AChR clusters. 1 Publication1
Natural variantiVAR_06875233A → V in CMS10; results in reduced stimulation of MUSK autophosphorylation. 2 Publications1
Natural variantiVAR_06875477T → M in CMS10; results in a decrease of branched, c-shaped and perforated AChR clusters. 1 Publication1
Natural variantiVAR_068756109G → C in CMS10; results in a significant reduction of AChR clusters. 1 Publication1
Natural variantiVAR_068757116V → M in CMS10. 1 Publication1
Natural variantiVAR_068758132H → Q in CMS10. 1 Publication1
Natural variantiVAR_068759139V → L in CMS10; results in a significant reduction of AChR clusters. 1 Publication1
Natural variantiVAR_068760146P → L in CMS10. 1 PublicationCorresponds to variant rs770987150dbSNPEnsembl.1
Natural variantiVAR_068761157L → R in CMS10. 1 Publication1
Natural variantiVAR_031246158R → Q in CMS10; reduced stimulation of MUSK autophosphorylation when associated with A-174; results in a significant reduction of AChR clusters. 2 PublicationsCorresponds to variant rs6811423dbSNPEnsembl.1
Natural variantiVAR_068762161G → R in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant rs758131044dbSNPEnsembl.1
Natural variantiVAR_068763166G → R in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant rs781227659dbSNPEnsembl.1
Natural variantiVAR_068764171G → D in CMS10; results in a significant reduction of AChR clusters. 1 Publication1
Natural variantiVAR_068765171G → R in CMS10. 1 Publication1
Natural variantiVAR_068766172G → R in CMS10. 1 PublicationCorresponds to variant rs768892432dbSNPEnsembl.1
Natural variantiVAR_027544180G → A in CMS10; results in a significant reduction of AChR clusters. 2 PublicationsCorresponds to variant rs118203994dbSNPEnsembl.1
Natural variantiVAR_068767180G → V in CMS10. 1 Publication1
Natural variantiVAR_068773469P → H in CMS10. 1 PublicationCorresponds to variant rs147185207dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi30S → W: Reduced stimulation of MUSK autophosphorylation. 1 Publication1
Mutagenesisi32V → A: Reduced stimulation of MUSK autophosphorylation. 1 Publication1
Mutagenesisi174R → A: Reduced stimulation of MUSK autophosphorylation; when associated with Q-158. 1 Publication1

Keywords - Diseasei

Congenital myasthenic syndrome, Disease mutation

Organism-specific databases

DisGeNETi285489.
MalaCardsiDOK7.
MIMi254300. phenotype.
OpenTargetsiENSG00000175920.
Orphaneti994. Fetal akinesia deformation sequence.
98913. Postsynaptic congenital myasthenic syndromes.
PharmGKBiPA162384035.

Polymorphism and mutation databases

BioMutaiDOK7.
DMDMi115311705.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002503711 – 504Protein Dok-7Add BLAST504

Proteomic databases

PaxDbiQ18PE1.
PeptideAtlasiQ18PE1.
PRIDEiQ18PE1.

PTM databases

iPTMnetiQ18PE1.
PhosphoSitePlusiQ18PE1.

Expressioni

Tissue specificityi

Preferentially expressed in skeletal muscle and heart. Present in thigh muscle, diaphragm and heart but not in the liver or spleen (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000175920.
CleanExiHS_DOK7.
GenevisibleiQ18PE1. HS.

Organism-specific databases

HPAiHPA059449.

Interactioni

Subunit structurei

Homodimer (By similarity). Forms a heterotetramer composed of 2 DOK7 and 2 MUSK molecules which facilitates MUSK trans-autophosphorylation on tyrosine residue and activation (By similarity). Interacts (via IRS-type PTB domain) with MUSK (via cytoplasmic part); requires MUSK phosphorylation.By similarity1 Publication

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi130124. 6 interactors.
IntActiQ18PE1. 4 interactors.
STRINGi9606.ENSP00000344432.

Structurei

3D structure databases

ProteinModelPortaliQ18PE1.
SMRiQ18PE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 109PHPROSITE-ProRule annotationAdd BLAST106
Domaini105 – 210IRS-type PTBPROSITE-ProRule annotationAdd BLAST106

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi262 – 359Ser-richAdd BLAST98

Domaini

The PH domain mediated binding to phospholipids with phosphoinositol headgroups. Affinity is highest for phosphatidyl 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate (By similarity).By similarity

Sequence similaritiesi

Contains 1 IRS-type PTB domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IHI2. Eukaryota.
ENOG4111MP1. LUCA.
GeneTreeiENSGT00390000015386.
HOGENOMiHOG000230953.
HOVERGENiHBG080009.
InParanoidiQ18PE1.
OMAiCLAPRDH.
OrthoDBiEOG091G064P.
PhylomeDBiQ18PE1.
TreeFamiTF332288.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR002404. IRS_PTB.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS51064. IRS_PTB. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q18PE1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTEAALVEGQ VKLRDGKKWK SRWLVLRKPS PVADCLLMLV YKDKSERIKG
60 70 80 90 100
LRERSSLTLE DICGLEPGLP YEGLVHTLAI VCLSQAIMLG FDSHEAMCAW
110 120 130 140 150
DARIRYALGE VHRFHVTVAP GTKLESGPAT LHLCNDVLVL ARDIPPAVTG
160 170 180 190 200
QWKLSDLRRY GAVPSGFIFE GGTRCGYWAG VFFLSSAEGE QISFLFDCIV
210 220 230 240 250
RGISPTKGPF GLRPVLPDPS PPGPSTVEER VAQEALETLQ LEKRLSLLSH
260 270 280 290 300
AGRPGSGGDD RSLSSSSSEA SHLDVSASSR LTAWPEQSSS SASTSQEGPR
310 320 330 340 350
PAAAQAAGEA MVGASRPPPK PLRPRQLQEV GRQSSSDSGI ATGSHSSYSS
360 370 380 390 400
SLSSYAGSSL DVWRATDELG SLLSLPAAGA PEPSLCTCLP GTVEYQVPTS
410 420 430 440 450
LRAHYDTPRS LCLAPRDHSP PSQGSPGNSA ARDSGGQTSA GCPSGWLGTR
460 470 480 490 500
RRGLVMEAPQ GSEATLPGPA PGEPWEAGGP HAGPPPAFFS ACPVCGGLKV

NPPP
Length:504
Mass (Da):53,097
Last modified:July 25, 2006 - v1
Checksum:i54750E0B0BC33317
GO
Isoform 2 (identifier: Q18PE1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.
     139-178: VLARDIPPAV...FEGGTRCGYW → MMSSSWPGTS...ADSSLKAGPG

Note: No experimental confirmation available.
Show »
Length:366
Mass (Da):37,161
Checksum:i8CFC71602C970AC3
GO
Isoform 4 (identifier: Q18PE1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     175-255: CGYWAGVFFL...SLLSHAGRPG → GWRLLPVLGR...TCGQAGQWRG
     256-504: Missing.

Note: No experimental confirmation available.
Show »
Length:255
Mass (Da):27,514
Checksum:i098963FABA4A7185
GO
Isoform 3 (identifier: Q18PE1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     500-504: VNPPP → GAAASAPGPA...ELEQRKAAPQ

Note: No experimental confirmation available.
Show »
Length:608
Mass (Da):63,938
Checksum:i384FFACAA0AD8359
GO

Sequence cautioni

The sequence BAC11367 differs from that shown. Contains a poly-A tail in the 5'region.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0687503E → K in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant rs763233743dbSNPEnsembl.1
Natural variantiVAR_06875131P → T in CMS10; results in a significant reduction of AChR clusters. 1 Publication1
Natural variantiVAR_06875233A → V in CMS10; results in reduced stimulation of MUSK autophosphorylation. 2 Publications1
Natural variantiVAR_06875345S → L Does not affect AChR clusters number or complexity. 2 PublicationsCorresponds to variant rs62272670dbSNPEnsembl.1
Natural variantiVAR_06875477T → M in CMS10; results in a decrease of branched, c-shaped and perforated AChR clusters. 1 Publication1
Natural variantiVAR_06875599A → V.1 PublicationCorresponds to variant rs138010842dbSNPEnsembl.1
Natural variantiVAR_068756109G → C in CMS10; results in a significant reduction of AChR clusters. 1 Publication1
Natural variantiVAR_068757116V → M in CMS10. 1 Publication1
Natural variantiVAR_068758132H → Q in CMS10. 1 Publication1
Natural variantiVAR_068759139V → L in CMS10; results in a significant reduction of AChR clusters. 1 Publication1
Natural variantiVAR_068760146P → L in CMS10. 1 PublicationCorresponds to variant rs770987150dbSNPEnsembl.1
Natural variantiVAR_068761157L → R in CMS10. 1 Publication1
Natural variantiVAR_031246158R → Q in CMS10; reduced stimulation of MUSK autophosphorylation when associated with A-174; results in a significant reduction of AChR clusters. 2 PublicationsCorresponds to variant rs6811423dbSNPEnsembl.1
Natural variantiVAR_068762161G → R in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant rs758131044dbSNPEnsembl.1
Natural variantiVAR_068763166G → R in CMS10; results in a significant reduction of AChR clusters. 1 PublicationCorresponds to variant rs781227659dbSNPEnsembl.1
Natural variantiVAR_068764171G → D in CMS10; results in a significant reduction of AChR clusters. 1 Publication1
Natural variantiVAR_068765171G → R in CMS10. 1 Publication1
Natural variantiVAR_068766172G → R in CMS10. 1 PublicationCorresponds to variant rs768892432dbSNPEnsembl.1
Natural variantiVAR_027544180G → A in CMS10; results in a significant reduction of AChR clusters. 2 PublicationsCorresponds to variant rs118203994dbSNPEnsembl.1
Natural variantiVAR_068767180G → V in CMS10. 1 Publication1
Natural variantiVAR_027545197D → N.1 PublicationCorresponds to variant rs16844422dbSNPEnsembl.1
Natural variantiVAR_027546261R → H.1 PublicationCorresponds to variant rs16844460dbSNPEnsembl.1
Natural variantiVAR_068768272H → Q.1 PublicationCorresponds to variant rs115614731dbSNPEnsembl.1
Natural variantiVAR_027547296Q → R.2 PublicationsCorresponds to variant rs6811423dbSNPEnsembl.1
Natural variantiVAR_068769323R → C.1 PublicationCorresponds to variant rs150728781dbSNPEnsembl.1
Natural variantiVAR_050508379G → R.Corresponds to variant rs6831659dbSNPEnsembl.1
Natural variantiVAR_068770382E → K.1 PublicationCorresponds to variant rs560463670dbSNPEnsembl.1
Natural variantiVAR_068771402R → Q.1 PublicationCorresponds to variant rs370039804dbSNPEnsembl.1
Natural variantiVAR_027548415P → S.1 PublicationCorresponds to variant rs16844464dbSNPEnsembl.1
Natural variantiVAR_027549427G → D.Corresponds to variant rs2020433dbSNPEnsembl.1
Natural variantiVAR_068772440A → T.1 PublicationCorresponds to variant rs753026831dbSNPEnsembl.1
Natural variantiVAR_027550451R → W.1 PublicationCorresponds to variant rs16844470dbSNPEnsembl.1
Natural variantiVAR_027551461G → D.3 PublicationsCorresponds to variant rs9684786dbSNPEnsembl.1
Natural variantiVAR_068773469P → H in CMS10. 1 PublicationCorresponds to variant rs147185207dbSNPEnsembl.1
Natural variantiVAR_068774503P → T.1 PublicationCorresponds to variant rs184556570dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0206331 – 138Missing in isoform 2. 1 PublicationAdd BLAST138
Alternative sequenceiVSP_020634139 – 178VLARD…RCGYW → MMSSSWPGTSPRLSRGSGSC LTSGATGPCQADSSLKAGPG in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_047252175 – 255CGYWA…AGRPG → GWRLLPVLGRGGADQLPVRL HRPRHLPHQGPLWAAAGSTR PKSPGTLDCGGACGPGSPGN PTAGEAAEPPLTCGQAGQWR G in isoform 4. CuratedAdd BLAST81
Alternative sequenceiVSP_047253256 – 504Missing in isoform 4. CuratedAdd BLAST249
Alternative sequenceiVSP_020635500 – 504VNPPP → GAAASAPGPATAHSGSPGPV AVDSPGPERPRGESPTYVNI PVSPSSRKQLHYMGLELQEA SEGVRGAGASLYAQIDIMAT ETAHRVGVRHARAREEQLSE LEQRKAAPQ in isoform 3. Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB220918 mRNA. Translation: BAE96739.1.
AK075037 mRNA. Translation: BAC11367.1. Sequence problems.
AK091037 mRNA. Translation: BAC03572.1.
AL590235 Genomic DNA. No translation available.
BC043568 mRNA. Translation: AAH43568.1.
BC062369 mRNA. Translation: AAH62369.1.
BC131544 mRNA. Translation: AAI31545.1.
BC141852 mRNA. Translation: AAI41853.1.
CCDSiCCDS3370.2. [Q18PE1-1]
CCDS54717.1. [Q18PE1-4]
RefSeqiNP_001158145.1. NM_001164673.1. [Q18PE1-4]
NP_001243825.1. NM_001256896.1.
NP_001288000.1. NM_001301071.1. [Q18PE1-3]
NP_775931.3. NM_173660.4. [Q18PE1-1]
UniGeneiHs.122110.
Hs.701584.

Genome annotation databases

EnsembliENST00000340083; ENSP00000344432; ENSG00000175920. [Q18PE1-1]
ENST00000507039; ENSP00000423614; ENSG00000175920. [Q18PE1-4]
GeneIDi285489.
KEGGihsa:285489.
UCSCiuc003ghd.4. human. [Q18PE1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

The Leiden Muscular Dystrophy pages, Docking protein 7 (DOK7)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB220918 mRNA. Translation: BAE96739.1.
AK075037 mRNA. Translation: BAC11367.1. Sequence problems.
AK091037 mRNA. Translation: BAC03572.1.
AL590235 Genomic DNA. No translation available.
BC043568 mRNA. Translation: AAH43568.1.
BC062369 mRNA. Translation: AAH62369.1.
BC131544 mRNA. Translation: AAI31545.1.
BC141852 mRNA. Translation: AAI41853.1.
CCDSiCCDS3370.2. [Q18PE1-1]
CCDS54717.1. [Q18PE1-4]
RefSeqiNP_001158145.1. NM_001164673.1. [Q18PE1-4]
NP_001243825.1. NM_001256896.1.
NP_001288000.1. NM_001301071.1. [Q18PE1-3]
NP_775931.3. NM_173660.4. [Q18PE1-1]
UniGeneiHs.122110.
Hs.701584.

3D structure databases

ProteinModelPortaliQ18PE1.
SMRiQ18PE1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130124. 6 interactors.
IntActiQ18PE1. 4 interactors.
STRINGi9606.ENSP00000344432.

PTM databases

iPTMnetiQ18PE1.
PhosphoSitePlusiQ18PE1.

Polymorphism and mutation databases

BioMutaiDOK7.
DMDMi115311705.

Proteomic databases

PaxDbiQ18PE1.
PeptideAtlasiQ18PE1.
PRIDEiQ18PE1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340083; ENSP00000344432; ENSG00000175920. [Q18PE1-1]
ENST00000507039; ENSP00000423614; ENSG00000175920. [Q18PE1-4]
GeneIDi285489.
KEGGihsa:285489.
UCSCiuc003ghd.4. human. [Q18PE1-1]

Organism-specific databases

CTDi285489.
DisGeNETi285489.
GeneCardsiDOK7.
GeneReviewsiDOK7.
HGNCiHGNC:26594. DOK7.
HPAiHPA059449.
MalaCardsiDOK7.
MIMi254300. phenotype.
610285. gene.
neXtProtiNX_Q18PE1.
OpenTargetsiENSG00000175920.
Orphaneti994. Fetal akinesia deformation sequence.
98913. Postsynaptic congenital myasthenic syndromes.
PharmGKBiPA162384035.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHI2. Eukaryota.
ENOG4111MP1. LUCA.
GeneTreeiENSGT00390000015386.
HOGENOMiHOG000230953.
HOVERGENiHBG080009.
InParanoidiQ18PE1.
OMAiCLAPRDH.
OrthoDBiEOG091G064P.
PhylomeDBiQ18PE1.
TreeFamiTF332288.

Enzyme and pathway databases

SignaLinkiQ18PE1.
SIGNORiQ18PE1.

Miscellaneous databases

ChiTaRSiDOK7. human.
GenomeRNAii285489.
PROiQ18PE1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175920.
CleanExiHS_DOK7.
GenevisibleiQ18PE1. HS.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR002404. IRS_PTB.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS51064. IRS_PTB. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDOK7_HUMAN
AccessioniPrimary (citable) accession number: Q18PE1
Secondary accession number(s): A2A499
, A2RRD4, E9PB56, Q6P6A6, Q86XG5, Q8N2J3, Q8NBC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: July 25, 2006
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.