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Protein

Mitochondrial brown fat uncoupling protein 1

Gene

UCP1

Organism
Suncus murinus (Asian house shrew) (Musk shrew)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.By similarity

Enzyme regulationi

Has no constitutive proton transporter activity and has to be activated by long-chain fatty acids/LCFAs. Inhibited by purine nucleotides. Both purine nucleotides and LCFAs bind the cytosolic side of the transporter and directly compete to activate or inhibit it. Activated by noradrenaline and reactive oxygen species.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial brown fat uncoupling protein 1Curated
Short name:
UCP 1Curated
Alternative name(s):
Solute carrier family 25 member 7By similarity
ThermogeninBy similarity
Gene namesi
Name:UCP11 Publication
Synonyms:SLC25A7By similarity
OrganismiSuncus murinus (Asian house shrew) (Musk shrew)
Taxonomic identifieri9378 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraSoricidaeCrocidurinaeSuncus

Subcellular locationi

  • Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10Mitochondrial intermembraneBy similarity10
Transmembranei11 – 33Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini34 – 74Mitochondrial matrixBy similarityAdd BLAST41
Transmembranei75 – 97Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini98 – 117Mitochondrial intermembraneBy similarityAdd BLAST20
Transmembranei118 – 134Helical; Name=3Sequence analysisAdd BLAST17
Topological domaini135 – 179Mitochondrial matrixBy similarityAdd BLAST45
Transmembranei180 – 196Helical; Name=4Sequence analysisAdd BLAST17
Topological domaini197 – 213Mitochondrial intermembraneBy similarityAdd BLAST17
Transmembranei214 – 233Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini234 – 267Mitochondrial matrixBy similarityAdd BLAST34
Transmembranei268 – 290Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini291 – 308Mitochondrial intermembraneBy similarityAdd BLAST18

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002530211 – 308Mitochondrial brown fat uncoupling protein 1Add BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei255Cysteine sulfenic acid (-SOH)By similarity1

Post-translational modificationi

May undergo sulfenylation upon cold exposure. May increase the sensitivity of UCP1 thermogenic function to the activation by noradrenaline probably through structural effects.By similarity
May undergo ubiquitin-mediated proteasomal degradation.By similarity

Keywords - PTMi

Oxidation

Expressioni

Tissue specificityi

Brown adipose tissue.1 Publication

Interactioni

Subunit structurei

Most probably functions as a monomer. Binds one purine nucleotide per monomer. However, has also been suggested to function as a homodimer or a homotetramer. Tightly associates with cardiolipin in the mitochondrion inner membrane; may stabilize and regulate its activity.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ18P97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 103Solcar 1Add BLAST93
Repeati112 – 202Solcar 2Add BLAST91
Repeati211 – 296Solcar 3Add BLAST86

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG009528.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002030. Mit_uncoupling_UCP-like.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q18P97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVASAEADVP PPTMLVKIAS AGLSACLADI ITFPLDTAKV RLQVQGERPN
60 70 80 90 100
APGVKYKGVL GTIATVAKTE GPLKLYGGLP AGIQRQISFA SLRIGLYDTV
110 120 130 140 150
QEYFNAHRKT PATLGNKISA GLMTGCVTVF IGQPTEVAKV RMQAQSSLHW
160 170 180 190 200
LKPRYSGTYN AYYVIVKTEG FLGLWKGTSL NLTRNVIINC TELVVYDVLK
210 220 230 240 250
EALVKNNVLA DDIPCHLLAA LTAGFCTTAL ASPVDVVKTR FINSPPGYYP
260 270 280 290 300
HVHNCALNML QKEGLRAFFK GFVPSFLRLG SWTVIMHVTF EQLKKELMKS

RQTVDCAT
Length:308
Mass (Da):33,551
Last modified:July 25, 2006 - v1
Checksum:i43CAE563214F8B29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB244816 mRNA. Translation: BAE96411.1.

Similar proteinsi

Entry informationi

Entry nameiUCP1_SUNMU
AccessioniPrimary (citable) accession number: Q18P97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 25, 2006
Last modified: August 30, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families