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Q18LE8 (KITH_ELHVK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sequence similarities

Belongs to the herpesviridae thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

TMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356Thymidine kinase
PRO_0000408156

Regions

Nucleotide binding61 – 688ATP By similarity

Sites

Active site861Proton acceptor By similarity
Binding site1221Substrate By similarity
Binding site1651Substrate By similarity
Binding site2081ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q18LE8 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 243F25646927F3D1

FASTA35640,857
        10         20         30         40         50         60 
MMDSRATYVP PKKISESNSN AEEDPTDCSK PITLKVPTVS ETVLATIPHK PQRHLTVYLE 

        70         80         90        100        110        120 
GCVGVGKTTM FKYVVDNMFV HTAYDEPMDH WTKWFPENIL QTIHEAVNLP TQEQHAYVFS 

       130        140        150        160        170        180 
CQNLIATSFL ARESGIVKTH PAPFDPSVDV ISIADRHALA AYVAFPIHHF LQGRFTYMEL 

       190        200        210        220        230        240 
QCMLWAFKQD SVDTIFLLQG CSEETLRRVK RRNRKVEHGV TIEYINSLQA AYTVILSTWY 

       250        260        270        280        290        300 
RATEYQYSAK RTVSEEISFF IAGPRRTLFY ILYDKRPITL PEIEILKLFR KISNDLKKLV 

       310        320        330        340        350 
LIPVNFQRLV YSSALRRLQD LLIVTPGVTS YIHNENVDTA TCAVADNPHF NHHDVS 

« Hide

References

[1]"Identification of novel rodent herpesviruses, including the first gammaherpesvirus of Mus musculus."
Ehlers B., Kuchler J., Yasmum N., Dural G., Voigt S., Schmidt-Chanasit J., Jakel T., Matuschka F.R., Richter D., Essbauer S., Hughes D.J., Summers C., Bennett M., Stewart J.P., Ulrich R.G.
J. Virol. 81:8091-8100(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Genetic and ultrastructural characterization of a European isolate of the fatal endotheliotropic elephant herpesvirus."
Ehlers B., Burkhardt S., Goltz M., Bergmann V., Ochs A., Weiler H., Hentschke J.
J. Gen. Virol. 82:475-482(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Endotheliotropic elephant herpesvirus, the first betaherpesvirus with a thymidine kinase gene."
Ehlers B., Dural G., Marschall M., Schregel V., Goltz M., Hentschke J.
J. Gen. Virol. 87:2781-2789(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF322977 Genomic DNA. Translation: ABG36571.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_ELHVK
AccessionPrimary (citable) accession number: Q18LE8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: July 25, 2006
Last modified: April 16, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families