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Q18LE8

- KITH_ELHVK

UniProt

Q18LE8 - KITH_ELHVK

Protein

Thymidine kinase

Gene
N/A
Organism
Elephantid herpesvirus 1 (isolate Asian elephant/Berlin/Kiba/1998) (EIHV-1) (Elephant endotheliotropic herpesvirus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei86 – 861Proton acceptorBy similarity
    Binding sitei122 – 1221SubstrateBy similarity
    Binding sitei165 – 1651SubstrateBy similarity
    Binding sitei208 – 2081ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi61 – 688ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW
    2. TMP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    OrganismiElephantid herpesvirus 1 (isolate Asian elephant/Berlin/Kiba/1998) (EIHV-1) (Elephant endotheliotropic herpesvirus)
    Taxonomic identifieri654902 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeProboscivirus
    Virus hostiElephas maximus (Indian elephant) [TaxID: 9783]
    Loxodonta africana (African elephant) [TaxID: 9785]
    Loxodonta cyclotis (African forest elephant) [TaxID: 99490]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 356356Thymidine kinasePRO_0000408156Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00693. Herpes_TK. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q18LE8-1 [UniParc]FASTAAdd to Basket

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    MMDSRATYVP PKKISESNSN AEEDPTDCSK PITLKVPTVS ETVLATIPHK    50
    PQRHLTVYLE GCVGVGKTTM FKYVVDNMFV HTAYDEPMDH WTKWFPENIL 100
    QTIHEAVNLP TQEQHAYVFS CQNLIATSFL ARESGIVKTH PAPFDPSVDV 150
    ISIADRHALA AYVAFPIHHF LQGRFTYMEL QCMLWAFKQD SVDTIFLLQG 200
    CSEETLRRVK RRNRKVEHGV TIEYINSLQA AYTVILSTWY RATEYQYSAK 250
    RTVSEEISFF IAGPRRTLFY ILYDKRPITL PEIEILKLFR KISNDLKKLV 300
    LIPVNFQRLV YSSALRRLQD LLIVTPGVTS YIHNENVDTA TCAVADNPHF 350
    NHHDVS 356
    Length:356
    Mass (Da):40,857
    Last modified:July 25, 2006 - v1
    Checksum:i243F25646927F3D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF322977 Genomic DNA. Translation: ABG36571.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF322977 Genomic DNA. Translation: ABG36571.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00693. Herpes_TK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Genetic and ultrastructural characterization of a European isolate of the fatal endotheliotropic elephant herpesvirus."
      Ehlers B., Burkhardt S., Goltz M., Bergmann V., Ochs A., Weiler H., Hentschke J.
      J. Gen. Virol. 82:475-482(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Endotheliotropic elephant herpesvirus, the first betaherpesvirus with a thymidine kinase gene."
      Ehlers B., Dural G., Marschall M., Schregel V., Goltz M., Hentschke J.
      J. Gen. Virol. 87:2781-2789(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiKITH_ELHVK
    AccessioniPrimary (citable) accession number: Q18LE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3