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Protein

Thymidine kinase

Gene
N/A
Organism
Elephantid herpesvirus 1 (isolate Asian elephant/Berlin/Kiba/1998) (EIHV-1) (Elephant endotheliotropic herpesvirus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton acceptorBy similarity
Binding sitei122 – 1221SubstrateBy similarity
Binding sitei165 – 1651SubstrateBy similarity
Binding sitei208 – 2081ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi61 – 688ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
  2. TMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
OrganismiElephantid herpesvirus 1 (isolate Asian elephant/Berlin/Kiba/1998) (EIHV-1) (Elephant endotheliotropic herpesvirus)
Taxonomic identifieri654902 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeProboscivirus
Virus hostiElephas maximus (Indian elephant) [TaxID: 9783]
Loxodonta africana (African elephant) [TaxID: 9785]
Loxodonta cyclotis (African forest elephant) [TaxID: 99490]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Thymidine kinasePRO_0000408156Add
BLAST

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18LE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDSRATYVP PKKISESNSN AEEDPTDCSK PITLKVPTVS ETVLATIPHK
60 70 80 90 100
PQRHLTVYLE GCVGVGKTTM FKYVVDNMFV HTAYDEPMDH WTKWFPENIL
110 120 130 140 150
QTIHEAVNLP TQEQHAYVFS CQNLIATSFL ARESGIVKTH PAPFDPSVDV
160 170 180 190 200
ISIADRHALA AYVAFPIHHF LQGRFTYMEL QCMLWAFKQD SVDTIFLLQG
210 220 230 240 250
CSEETLRRVK RRNRKVEHGV TIEYINSLQA AYTVILSTWY RATEYQYSAK
260 270 280 290 300
RTVSEEISFF IAGPRRTLFY ILYDKRPITL PEIEILKLFR KISNDLKKLV
310 320 330 340 350
LIPVNFQRLV YSSALRRLQD LLIVTPGVTS YIHNENVDTA TCAVADNPHF

NHHDVS
Length:356
Mass (Da):40,857
Last modified:July 25, 2006 - v1
Checksum:i243F25646927F3D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322977 Genomic DNA. Translation: ABG36571.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322977 Genomic DNA. Translation: ABG36571.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genetic and ultrastructural characterization of a European isolate of the fatal endotheliotropic elephant herpesvirus."
    Ehlers B., Burkhardt S., Goltz M., Bergmann V., Ochs A., Weiler H., Hentschke J.
    J. Gen. Virol. 82:475-482(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Endotheliotropic elephant herpesvirus, the first betaherpesvirus with a thymidine kinase gene."
    Ehlers B., Dural G., Marschall M., Schregel V., Goltz M., Hentschke J.
    J. Gen. Virol. 87:2781-2789(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKITH_ELHVK
AccessioniPrimary (citable) accession number: Q18LE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: July 25, 2006
Last modified: January 7, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.