Q18LE8 (KITH_ELHVK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Thymidine kinase EC=2.7.1.21
Organism	Elephantid herpesvirus 1 (isolate Asian elephant/Berlin/Kiba/1998) (EIHV-1) (Elephant endotheliotropic herpesvirus)
Taxonomic identifier	654902 [NCBI]
Taxonomic lineage	Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Betaherpesvirinae › Proboscivirus › Elephantid herpesvirus 1
Virus host	Elephas maximus (Indian elephant) [TaxID: 9783] Loxodonta africana (African elephant) [TaxID: 9785] Loxodonta cyclotis (African forest elephant) [TaxID: 99490]

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate.
Sequence similarities	Belongs to the herpesviruses thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW TMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thymidine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Thymidine kinase		PRO_0000408156
Regions
	Nucleotide binding	61 – 68	8	ATP By similarity
Sites
	Active site	86	1	Proton acceptor By similarity
	Binding site	122	1	Substrate By similarity
	Binding site	165	1	Substrate By similarity
	Binding site	208	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q18LE8 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 243F25646927F3D1	FASTA	356	40,857
	10 20 30 40 50 60 MMDSRATYVP PKKISESNSN AEEDPTDCSK PITLKVPTVS ETVLATIPHK PQRHLTVYLE 70 80 90 100 110 120 GCVGVGKTTM FKYVVDNMFV HTAYDEPMDH WTKWFPENIL QTIHEAVNLP TQEQHAYVFS 130 140 150 160 170 180 CQNLIATSFL ARESGIVKTH PAPFDPSVDV ISIADRHALA AYVAFPIHHF LQGRFTYMEL 190 200 210 220 230 240 QCMLWAFKQD SVDTIFLLQG CSEETLRRVK RRNRKVEHGV TIEYINSLQA AYTVILSTWY 250 260 270 280 290 300 RATEYQYSAK RTVSEEISFF IAGPRRTLFY ILYDKRPITL PEIEILKLFR KISNDLKKLV 310 320 330 340 350 LIPVNFQRLV YSSALRRLQD LLIVTPGVTS YIHNENVDTA TCAVADNPHF NHHDVS

References

[1]	"Identification of novel rodent herpesviruses, including the first gammaherpesvirus of Mus musculus." Ehlers B., Kuchler J., Yasmum N., Dural G., Voigt S., Schmidt-Chanasit J., Jakel T., Matuschka F.R., Richter D., Essbauer S., Hughes D.J., Summers C., Bennett M., Stewart J.P., Ulrich R.G. J. Virol. 81:8091-8100(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Genetic and ultrastructural characterization of a European isolate of the fatal endotheliotropic elephant herpesvirus." Ehlers B., Burkhardt S., Goltz M., Bergmann V., Ochs A., Weiler H., Hentschke J. J. Gen. Virol. 82:475-482(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Endotheliotropic elephant herpesvirus, the first betaherpesvirus with a thymidine kinase gene." Ehlers B., Dural G., Marschall M., Schregel V., Goltz M., Hentschke J. J. Gen. Virol. 87:2781-2789(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF322977 Genomic DNA. Translation: ABG36571.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001889. Herpes_TK. [Graphical view]
Pfam	PF00693. Herpes_TK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_ELHVK

Accession

Primary (citable) accession number: Q18LE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 3, 2011
Last sequence update:	July 25, 2006
Last modified:	April 3, 2013
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program