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Protein

Cell division protein FtsZ

Gene

ftsZ1

Organism
Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei192GTPUniRule annotation1
Binding sitei196GTPUniRule annotation1
Binding sitei239GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 78GTPUniRule annotation5
Nucleotide bindingi161 – 163GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, SeptationUniRule annotation

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZ1Imported
Synonyms:ftsZUniRule annotation
Ordered Locus Names:HQ_1243AImported
OrganismiHaloquadratum walsbyi (strain DSM 16790 / HBSQ001)Imported
Taxonomic identifieri362976 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHaloferacaceaeHaloquadratum
Proteomesi
  • UP000001975 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi362976.HQ1243A.

Structurei

3D structure databases

ProteinModelPortaliQ18KS2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 257TubulinInterPro annotationAdd BLAST192
Domaini259 – 376Tubulin_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02201. Archaea.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiIWGTSVD.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18KS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSIVDDAID EAEKTGGGDA VDGAAVEAEP ESESTADTGA TNDGLSQSGT
60 70 80 90 100
MTDDELQDVL EDLQTDITVV GCGGAGGNTV DRMHQEGIEG ATLVAANTDV
110 120 130 140 150
QHLVEIESDT KILMGEQKTQ GRGAGSLPQV GEEAAIESQE EIYNAIEGSD
160 170 180 190 200
MVFVTAGLGG GTGTGSAPVV AKAARESNAL TIAIVTTPFT AEGEVRRTNA
210 220 230 240 250
EAGLERLRDV ADTVIVVPND RLLDSVGKLP VRQAFKVSDE VLMRSVKGIT
260 270 280 290 300
ELITKPGLVN LDFADVKTVM QRGGVAMIGL GESDSESKAQ DSVKSALRSP
310 320 330 340 350
LLDVDISSAN SALVNVAGGS DMSIEEAEGV VEEIHNRIHP DARIIWGTSV
360 370 380 390 400
DDDLDGTMRT MIVVTGVESP QIYGSSDTAA QSNAQGVEGM RVDTDGNGRV
410 420 430
NAAESVETDT GSNAETDEAE TATRTEVPFP DEDADFIE
Length:438
Mass (Da):45,530
Last modified:July 25, 2006 - v1
Checksum:iA7528E833A8DC915
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180088 Genomic DNA. Translation: CAJ51372.1.
RefSeqiWP_011570533.1. NC_008212.1.

Genome annotation databases

EnsemblBacteriaiCAJ51372; CAJ51372; HQ_1243A.
GeneIDi4193998.
KEGGihwa:HQ_1243A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180088 Genomic DNA. Translation: CAJ51372.1.
RefSeqiWP_011570533.1. NC_008212.1.

3D structure databases

ProteinModelPortaliQ18KS2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi362976.HQ1243A.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ51372; CAJ51372; HQ_1243A.
GeneIDi4193998.
KEGGihwa:HQ_1243A.

Phylogenomic databases

eggNOGiarCOG02201. Archaea.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiIWGTSVD.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ18KS2_HALWD
AccessioniPrimary (citable) accession number: Q18KS2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 30, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.