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Q18JB5

- FTHS_HALWD

UniProt

Q18JB5 - FTHS_HALWD

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi83 – 908ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHWAL362976:GJSR-821-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:HQ_1768A
    OrganismiHaloquadratum walsbyi (strain DSM 16790 / HBSQ001)
    Taxonomic identifieri362976 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloquadratum
    ProteomesiUP000001975: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 580580Formate--tetrahydrofolate ligasePRO_0000293074Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi362976.HQ1768A.

    Structurei

    3D structure databases

    ProteinModelPortaliQ18JB5.
    SMRiQ18JB5. Positions 19-578.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiCETGNIM.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q18JB5-1 [UniParc]FASTAAdd to Basket

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    MTDDSKDTDL SEDNGFPTDY EIAQNADMTP IWDLLEPWDL GNDDLSYYGE    50
    YTAKLSHDAV DHLREEAKTR ENNLILVTGM TPTPMGEGKT VTTVGLGQTL 100
    NHLDEEAMIA IREPSLGPVF GVKGGAAGGG YSQVLPMEEI NLHFTGDLHA 150
    LTSAHNLIAA MLDAKLSQSD EFDVDVNDIS WPRALDMNDR ALRETVIGLG 200
    GESGGVPRED GFLLTAASEL MAVLCLSSDL EDLKMRVSRI IVGYENDGEP 250
    ITVDDIDATG PVTMLLRDAI EPNVVQTIEG TPAFVHGGPF ANIAHGTNSL 300
    IADKAAFGMG DYLVTEAGFG SDLGAEKFMN IVCRLGDMTP DAITLVASVR 350
    ALKYHGLDMW PADIDEINGA GVDALEAGFV NLDKHVTNLQ KFGIPVVVAV 400
    NRFPNDTDVE VNAVLNHCRN DLNVKAASST VFAEGSEGGV ELAERVIGAV 450
    ESSDPEDFEY LYPADATIKE KIETVATEIY GAGSVNYSTD AEDDIERMRE 500
    LGFDTVPVCL SKTFHSLTDD ARQKGAPTGW TLNVRKLYPS AGAGFIVALT 550
    GDVLTMPGLP ADPAAADMDI DADGDITGLF 580
    Length:580
    Mass (Da):62,054
    Last modified:July 25, 2006 - v1
    Checksum:i1BA472E2A03593D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180088 Genomic DNA. Translation: CAJ51896.1.
    RefSeqiWP_011571043.1. NC_008212.1.
    YP_657533.1. NC_008212.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ51896; CAJ51896; HQ_1768A.
    GeneIDi4193985.
    KEGGihwa:HQ1768A.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180088 Genomic DNA. Translation: CAJ51896.1 .
    RefSeqi WP_011571043.1. NC_008212.1.
    YP_657533.1. NC_008212.1.

    3D structure databases

    ProteinModelPortali Q18JB5.
    SMRi Q18JB5. Positions 19-578.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 362976.HQ1768A.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ51896 ; CAJ51896 ; HQ_1768A .
    GeneIDi 4193985.
    KEGGi hwa:HQ1768A.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi CETGNIM.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci HWAL362976:GJSR-821-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the square archaeon Haloquadratum walsbyi: life at the limits of water activity."
      Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F., Pfeiffer F., Oesterhelt D.
      BMC Genomics 7:169-169(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 16790 / HBSQ001.

    Entry informationi

    Entry nameiFTHS_HALWD
    AccessioniPrimary (citable) accession number: Q18JB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3