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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi83 – 908ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHWAL362976:GJSR-821-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:HQ_1768A
OrganismiHaloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Taxonomic identifieri362976 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloquadratum
ProteomesiUP000001975 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 580580Formate--tetrahydrofolate ligasePRO_0000293074Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi362976.HQ1768A.

Structurei

3D structure databases

ProteinModelPortaliQ18JB5.
SMRiQ18JB5. Positions 19-578.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18JB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDDSKDTDL SEDNGFPTDY EIAQNADMTP IWDLLEPWDL GNDDLSYYGE
60 70 80 90 100
YTAKLSHDAV DHLREEAKTR ENNLILVTGM TPTPMGEGKT VTTVGLGQTL
110 120 130 140 150
NHLDEEAMIA IREPSLGPVF GVKGGAAGGG YSQVLPMEEI NLHFTGDLHA
160 170 180 190 200
LTSAHNLIAA MLDAKLSQSD EFDVDVNDIS WPRALDMNDR ALRETVIGLG
210 220 230 240 250
GESGGVPRED GFLLTAASEL MAVLCLSSDL EDLKMRVSRI IVGYENDGEP
260 270 280 290 300
ITVDDIDATG PVTMLLRDAI EPNVVQTIEG TPAFVHGGPF ANIAHGTNSL
310 320 330 340 350
IADKAAFGMG DYLVTEAGFG SDLGAEKFMN IVCRLGDMTP DAITLVASVR
360 370 380 390 400
ALKYHGLDMW PADIDEINGA GVDALEAGFV NLDKHVTNLQ KFGIPVVVAV
410 420 430 440 450
NRFPNDTDVE VNAVLNHCRN DLNVKAASST VFAEGSEGGV ELAERVIGAV
460 470 480 490 500
ESSDPEDFEY LYPADATIKE KIETVATEIY GAGSVNYSTD AEDDIERMRE
510 520 530 540 550
LGFDTVPVCL SKTFHSLTDD ARQKGAPTGW TLNVRKLYPS AGAGFIVALT
560 570 580
GDVLTMPGLP ADPAAADMDI DADGDITGLF
Length:580
Mass (Da):62,054
Last modified:July 25, 2006 - v1
Checksum:i1BA472E2A03593D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180088 Genomic DNA. Translation: CAJ51896.1.
RefSeqiWP_011571043.1. NC_008212.1.
YP_657533.1. NC_008212.1.

Genome annotation databases

EnsemblBacteriaiCAJ51896; CAJ51896; HQ_1768A.
GeneIDi4193985.
KEGGihwa:HQ1768A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180088 Genomic DNA. Translation: CAJ51896.1.
RefSeqiWP_011571043.1. NC_008212.1.
YP_657533.1. NC_008212.1.

3D structure databases

ProteinModelPortaliQ18JB5.
SMRiQ18JB5. Positions 19-578.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi362976.HQ1768A.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ51896; CAJ51896; HQ_1768A.
GeneIDi4193985.
KEGGihwa:HQ1768A.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciHWAL362976:GJSR-821-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the square archaeon Haloquadratum walsbyi: life at the limits of water activity."
    Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F., Pfeiffer F., Oesterhelt D.
    BMC Genomics 7:169-169(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16790 / HBSQ001.

Entry informationi

Entry nameiFTHS_HALWD
AccessioniPrimary (citable) accession number: Q18JB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 25, 2006
Last modified: April 1, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.