Q18JB5 (FTHS_HALWD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase
EC=6.3.4.3

Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS

Gene names

Name:	fhs
Ordered Locus Names:	HQ1768A

Organism

Haloquadratum walsbyi (strain DSM 16790) [Complete proteome] [HAMAP]

Taxonomic identifier

362976 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloquadratum

Protein attributes

Sequence length	580 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 580	580	Formate--tetrahydrofolate ligase HAMAP MF_01543		PRO_0000293074
Regions
	Nucleotide binding	83 – 90	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q18JB5 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 1BA472E2A03593D6	FASTA	580	62,054
	10 20 30 40 50 60 MTDDSKDTDL SEDNGFPTDY EIAQNADMTP IWDLLEPWDL GNDDLSYYGE YTAKLSHDAV 70 80 90 100 110 120 DHLREEAKTR ENNLILVTGM TPTPMGEGKT VTTVGLGQTL NHLDEEAMIA IREPSLGPVF 130 140 150 160 170 180 GVKGGAAGGG YSQVLPMEEI NLHFTGDLHA LTSAHNLIAA MLDAKLSQSD EFDVDVNDIS 190 200 210 220 230 240 WPRALDMNDR ALRETVIGLG GESGGVPRED GFLLTAASEL MAVLCLSSDL EDLKMRVSRI 250 260 270 280 290 300 IVGYENDGEP ITVDDIDATG PVTMLLRDAI EPNVVQTIEG TPAFVHGGPF ANIAHGTNSL 310 320 330 340 350 360 IADKAAFGMG DYLVTEAGFG SDLGAEKFMN IVCRLGDMTP DAITLVASVR ALKYHGLDMW 370 380 390 400 410 420 PADIDEINGA GVDALEAGFV NLDKHVTNLQ KFGIPVVVAV NRFPNDTDVE VNAVLNHCRN 430 440 450 460 470 480 DLNVKAASST VFAEGSEGGV ELAERVIGAV ESSDPEDFEY LYPADATIKE KIETVATEIY 490 500 510 520 530 540 GAGSVNYSTD AEDDIERMRE LGFDTVPVCL SKTFHSLTDD ARQKGAPTGW TLNVRKLYPS 550 560 570 580 AGAGFIVALT GDVLTMPGLP ADPAAADMDI DADGDITGLF

References

[1]

"The genome of the square archaeon Haloquadratum walsbyi: life at the limits of water activity." Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F., Pfeiffer F., Oesterhelt D. BMC Genomics 7:169-169(2006) [PubMed: 16820047] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 16790.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM180088 Genomic DNA. Translation: CAJ51896.1.
RefSeq	YP_657533.1. NC_008212.1.
3D structure databases
ProteinModelPortal	Q18JB5.
SMR	Q18JB5. Positions 19-578.
ModBase	Search...
Protein-protein interaction databases
STRING	Q18JB5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4193985.
GenomeReviews	Gene locus HQ1768A in contig AM180088_GR.
KEGG	hwa:HQ1768A.
NMPDR	fig|362976.6.peg.776.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG06240.
HOGENOM	HBG677721.
OMA	EIMAVLC.
PhylomeDB	Q18JB5.
ProtClustDB	CLSK758602.
Enzyme and pathway databases
BioCyc	HWAL362976:HQ1768A-MONOMER.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS_HALWD

Accession

Primary (citable) accession number: Q18JB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	July 25, 2006
Last modified:	November 16, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program