SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q18JB5

- FTHS_HALWD

UniProt

Q18JB5 - FTHS_HALWD

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Formate--tetrahydrofolate ligase

Gene
fhs, HQ_1768A
Organism
Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi83 – 908ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHWAL362976:GJSR-821-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:HQ_1768A
OrganismiHaloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Taxonomic identifieri362976 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloquadratum
ProteomesiUP000001975: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 580580Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000293074Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi362976.HQ1768A.

Structurei

3D structure databases

ProteinModelPortaliQ18JB5.
SMRiQ18JB5. Positions 19-578.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCETGNIM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18JB5-1 [UniParc]FASTAAdd to Basket

« Hide

MTDDSKDTDL SEDNGFPTDY EIAQNADMTP IWDLLEPWDL GNDDLSYYGE    50
YTAKLSHDAV DHLREEAKTR ENNLILVTGM TPTPMGEGKT VTTVGLGQTL 100
NHLDEEAMIA IREPSLGPVF GVKGGAAGGG YSQVLPMEEI NLHFTGDLHA 150
LTSAHNLIAA MLDAKLSQSD EFDVDVNDIS WPRALDMNDR ALRETVIGLG 200
GESGGVPRED GFLLTAASEL MAVLCLSSDL EDLKMRVSRI IVGYENDGEP 250
ITVDDIDATG PVTMLLRDAI EPNVVQTIEG TPAFVHGGPF ANIAHGTNSL 300
IADKAAFGMG DYLVTEAGFG SDLGAEKFMN IVCRLGDMTP DAITLVASVR 350
ALKYHGLDMW PADIDEINGA GVDALEAGFV NLDKHVTNLQ KFGIPVVVAV 400
NRFPNDTDVE VNAVLNHCRN DLNVKAASST VFAEGSEGGV ELAERVIGAV 450
ESSDPEDFEY LYPADATIKE KIETVATEIY GAGSVNYSTD AEDDIERMRE 500
LGFDTVPVCL SKTFHSLTDD ARQKGAPTGW TLNVRKLYPS AGAGFIVALT 550
GDVLTMPGLP ADPAAADMDI DADGDITGLF 580
Length:580
Mass (Da):62,054
Last modified:July 25, 2006 - v1
Checksum:i1BA472E2A03593D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180088 Genomic DNA. Translation: CAJ51896.1.
RefSeqiWP_011571043.1. NC_008212.1.
YP_657533.1. NC_008212.1.

Genome annotation databases

EnsemblBacteriaiCAJ51896; CAJ51896; HQ_1768A.
GeneIDi4193985.
KEGGihwa:HQ1768A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180088 Genomic DNA. Translation: CAJ51896.1 .
RefSeqi WP_011571043.1. NC_008212.1.
YP_657533.1. NC_008212.1.

3D structure databases

ProteinModelPortali Q18JB5.
SMRi Q18JB5. Positions 19-578.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 362976.HQ1768A.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ51896 ; CAJ51896 ; HQ_1768A .
GeneIDi 4193985.
KEGGi hwa:HQ1768A.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi CETGNIM.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci HWAL362976:GJSR-821-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the square archaeon Haloquadratum walsbyi: life at the limits of water activity."
    Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F., Pfeiffer F., Oesterhelt D.
    BMC Genomics 7:169-169(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16790 / HBSQ001.

Entry informationi

Entry nameiFTHS_HALWD
AccessioniPrimary (citable) accession number: Q18JB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 25, 2006
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi