Q18J88 (KITH_HALWD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:	tdk
Ordered Locus Names:	HQ_1795A

Organism

Haloquadratum walsbyi (strain DSM 16790) [Complete proteome] [HAMAP]

Taxonomic identifier

362976 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloquadratum › Haloquadratum walsbyi

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00124.
Sequence similarities	Belongs to the thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidine kinase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	Thymidine kinase HAMAP-Rule MF_00124		PRO_1000018156
Regions
	Nucleotide binding	15 – 22	8	ATP By similarity
	Nucleotide binding	121 – 124	4	ATP By similarity
Sites
	Active site	122	1	Proton acceptor Potential
	Metal binding	178	1	Zinc By similarity
	Metal binding	181	1	Zinc By similarity
	Metal binding	216	1	Zinc By similarity
	Metal binding	219	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q18J88 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 9564E79B078512D2	FASTA	225	24,833
	10 20 30 40 50 60 MRAITNSGWI EVVTGSMFSG KTEELLRRLR RAEIAGQSIA VFKPAVDDRY GETTVGSHVG 70 80 90 100 110 120 RQWEAAVVPN EGEDIWNIKH ELSKKKQNHR TTTQCRSGDG TNNPGGVIPS NDDSVDVVAI 130 140 150 160 170 180 DEANFFSTEL VSVCESLAND GYRVVVSGTD QTYRGEPFEP LPQLMAVAEY VDKLQAICTQ 190 200 210 220 CGEPATRNQR LVDDSPAHID DPTIVVGADE TYEARCRNCH ILRHE

References

[1]

"The genome of the square archaeon Haloquadratum walsbyi: life at the limits of water activity." Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F., Pfeiffer F., Oesterhelt D. BMC Genomics 7:169-169(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 16790.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM180088 Genomic DNA. Translation: CAJ51923.1.
RefSeq	YP_657560.1. NC_008212.1.
3D structure databases
ProteinModelPortal	Q18J88.
ModBase	Search...
Protein-protein interaction databases
STRING	362976.HQ1795A.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ51923; CAJ51923; HQ_1795A.
GeneID	4194746.
KEGG	hwa:HQ1795A.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1435.
HOGENOM	HOG000076390.
KO	K00857.
OMA	KVHAICV.
ProtClustDB	PRK04296.
Enzyme and pathway databases
BioCyc	HWAL362976:GJSR-855-MONOMER.
Family and domain databases
HAMAP	MF_00124. Thymidine_kinase.
InterPro	IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. IPR020634. Thymidine_kinase_subgr. [Graphical view]
PANTHER	PTHR11441. PTHR11441. 1 hit.
Pfam	PF00265. TK. 2 hits. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_HALWD

Accession

Primary (citable) accession number: Q18J88

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 25, 2006
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program