Q18J40 (MSRA_HALWD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase

Gene names

Name:	msrA
Ordered Locus Names:	HQ1843A

Organism

Haloquadratum walsbyi (strain DSM 16790) [Complete proteome] [HAMAP]

Taxonomic identifier

362976 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloquadratum

Protein attributes

Sequence length	174 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 174	174	Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401		PRO_1000145411
Sites
	Active site	11	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q18J40 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 66EC28E7F0F3BEA1	FASTA	174	19,622
	10 20 30 40 50 60 MSETATVGGG CFWCTEAAMK ELAGVNTVTS GYAGGDIDNP TYKQVCSGTT DHAEVVQIEY 70 80 90 100 110 120 DPTKIEYSEL LEVFFATHDP TQLNRQGPDV GTQYRSIILT HTAEQRATAE AYIEALNDHY 130 140 150 160 170 DDAIVTEIES LERFWSAEEY HQDYFEKNPS DAYCRMHAQP KVEKVRETFT EKLT

References

[1]

"The genome of the square archaeon Haloquadratum walsbyi: life at the limits of water activity." Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F., Pfeiffer F., Oesterhelt D. BMC Genomics 7:169-169(2006) [PubMed: 16820047] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 16790.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM180088 Genomic DNA. Translation: CAJ51971.1.
RefSeq	YP_657609.1. NC_008212.1.
3D structure databases
ProteinModelPortal	Q18J40.
ModBase	Search...
Protein-protein interaction databases
STRING	Q18J40.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4194306.
GenomeReviews	Gene locus HQ1843A in contig AM180088_GR.
KEGG	hwa:HQ1843A.
NMPDR	fig|362976.6.peg.851.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG08844.
HOGENOM	HBG748152.
OMA	SAIYCTS.
PhylomeDB	Q18J40.
ProtClustDB	PRK14054.
Enzyme and pathway databases
BioCyc	HWAL362976:HQ1843A-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_HALWD

Accession

Primary (citable) accession number: Q18J40

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 25, 2006
Last modified:	November 16, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program