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Protein

Glyceraldehyde-3-phosphate dehydrogenase

Gene

gap3

Organism
Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H.UniRule annotationSAAS annotation

Pathway: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gap3), Glyceraldehyde-3-phosphate dehydrogenase (gap1)
  2. no protein annotated in this organism
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (pykA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei109 – 1091NAD; via amide nitrogenUniRule annotation
Active sitei139 – 1391NucleophileUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 122NADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

NADUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciHWAL362976:GJSR-1104-MONOMER.
UniPathwayiUPA00109; UER00184.

Names & Taxonomyi

Protein namesi
Recommended name:
Glyceraldehyde-3-phosphate dehydrogenaseUniRule annotation (EC:1.2.1.59UniRule annotation)
Short name:
GAPDHUniRule annotation
Alternative name(s):
NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenaseUniRule annotation
Gene namesi
Name:gap3Imported
Synonyms:gapUniRule annotation
Ordered Locus Names:HQ_2025AImported
OrganismiHaloquadratum walsbyi (strain DSM 16790 / HBSQ001)Imported
Taxonomic identifieri362976 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHaloferacaceaeHaloquadratum
ProteomesiUP000001975 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi362976.HQ2025A.

Structurei

3D structure databases

ProteinModelPortaliQ18IL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni138 – 1403Glyceraldehyde 3-phosphate bindingUniRule annotation
Regioni185 – 1862Glyceraldehyde 3-phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0057.
HOGENOMiHOG000223361.
KOiK00150.
OMAiASESRIH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00559. G3P_dehdrog_arch.
InterProiIPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR006436. Glyceraldehyde-3-P_DH_2_arc.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000149. GAP_DH. 1 hit.
SMARTiSM00846. Gp_dh_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01546. GAPDH-II_archae. 1 hit.
PROSITEiPS00071. GAPDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18IL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHVGVNGYG TIGKRVADAV DMMPDMELTG VSKASPNHTA DAAADRGYDI
60 70 80 90 100
YVPEERHDRW ADTEMTVTGD VHELIEISDI VADTTPPGMG AEYRPIYEEH
110 120 130 140 150
DTPALFQGGE SADAVEASFT ARANYSEATN KDYVRIVSCN TTGLNRMFAP
160 170 180 190 200
LHEEYGVERA SITLVRCRGE HAVTSADPMT IPSYHGPDAR EVIPDMGPIT
210 220 230 240 250
TMGMKTPSVR HHFHGINVTL GAEPTAAEVR DLLASESRIH VIDDDLGIDS
260 270 280 290 300
GWELQEFALD RGRDRMNLYE NQIFEDSITM DGTQLHLFQC IHRESDVVPE
310 320 330
SIDAIRAMLA DADAVESIEL TNEVMGIGDI
Length:330
Mass (Da):36,247
Last modified:July 25, 2006 - v1
Checksum:iAEE9C1D480BCB381
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180088 Genomic DNA. Translation: CAJ52152.1.
RefSeqiWP_011571293.1. NC_008212.1.
YP_657783.1. NC_008212.1.

Genome annotation databases

EnsemblBacteriaiCAJ52152; CAJ52152; HQ_2025A.
GeneIDi4194011.
KEGGihwa:HQ2025A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180088 Genomic DNA. Translation: CAJ52152.1.
RefSeqiWP_011571293.1. NC_008212.1.
YP_657783.1. NC_008212.1.

3D structure databases

ProteinModelPortaliQ18IL8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi362976.HQ2025A.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ52152; CAJ52152; HQ_2025A.
GeneIDi4194011.
KEGGihwa:HQ2025A.

Phylogenomic databases

eggNOGiCOG0057.
HOGENOMiHOG000223361.
KOiK00150.
OMAiASESRIH.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00184.
BioCyciHWAL362976:GJSR-1104-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00559. G3P_dehdrog_arch.
InterProiIPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR006436. Glyceraldehyde-3-P_DH_2_arc.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000149. GAP_DH. 1 hit.
SMARTiSM00846. Gp_dh_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01546. GAPDH-II_archae. 1 hit.
PROSITEiPS00071. GAPDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the square archaeon Haloquadratum walsbyi: life at the limits of water activity."
    Bolhuis H.H., Palm P.P., Wende A.W., Falb M.M., Rampp M.M., Rodriguez-Valera F.F., Pfeiffer F.F., Oesterhelt D.D.
    BMC Genomics 7:169-169(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16790 / HBSQ001Imported.

Entry informationi

Entry nameiQ18IL8_HALWD
AccessioniPrimary (citable) accession number: Q18IL8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: June 24, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.