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Q18GX8 (THIM_HALWD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:HQ_2656A
OrganismHaloquadratum walsbyi (strain DSM 16790 / HBSQ001) [Complete proteome] [HAMAP]
Taxonomic identifier362976 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloquadratum

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383913

Sites

Binding site551Substrate; via amide nitrogen By similarity
Binding site1311ATP By similarity
Binding site1771ATP By similarity
Binding site2041Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q18GX8 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 5DCBA117E3CC86D1

FASTA28829,352
        10         20         30         40         50         60 
MNEDTTTLVE ETNTTTQAAL RQLSQTTPLV NAITNDVTVN QVANIILHWG GLPVMSDDVR 

        70         80         90        100        110        120 
ELDEMVNAAE ACLLNMGTVS ETGEEAMMTA GQAASEHDAG LVLDPVGAGA TATRSRVAER 

       130        140        150        160        170        180 
LSTTLDVDVI NGNRGEVAAL VGEDAEVRGV ESVGEHPDAA ETAIACAQHT EAVVVSSGVT 

       190        200        210        220        230        240 
DIVATAETAF ELNVGDEMLG TLVGTGCMLG GTIAAFCGGL DDPLTAALTG TVAFGLAGEA 

       250        260        270        280 
AANGEFGEYA GPASYETTVL DAAAGTDPEM IAAVDIDNRV NRVLAEAK 

« Hide

References

[1]"The genome of the square archaeon Haloquadratum walsbyi: life at the limits of water activity."
Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F., Pfeiffer F., Oesterhelt D.
BMC Genomics 7:169-169(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 16790 / HBSQ001.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM180088 Genomic DNA. Translation: CAJ52767.1.
RefSeqYP_658373.1. NC_008212.1.

3D structure databases

ProteinModelPortalQ18GX8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING362976.HQ2656A.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ52767; CAJ52767; HQ_2656A.
GeneID4194768.
KEGGhwa:HQ2656A.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMASPVMAHA.
ProtClustDBCLSK760160.

Enzyme and pathway databases

BioCycHWAL362976:GJSR-1757-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
ProtoNetSearch...

Entry information

Entry nameTHIM_HALWD
AccessionPrimary (citable) accession number: Q18GX8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 25, 2006
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways