Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q18GX5 (DNLI2_HALWD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase 2

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] 2
Gene names
Name:lig2
Ordered Locus Names:HQ_2659A
OrganismHaloquadratum walsbyi (strain DSM 16790 / HBSQ001) [Complete proteome] [HAMAP]
Taxonomic identifier362976 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloquadratum

Protein attributes

Sequence length618 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 618618DNA ligase 2 HAMAP-Rule MF_00407
PRO_0000365247

Sites

Active site3141N6-AMP-lysine intermediate By similarity
Binding site3121ATP By similarity
Binding site3191ATP By similarity
Binding site3341ATP By similarity
Binding site3631ATP By similarity
Binding site4031ATP By similarity
Binding site4761ATP By similarity
Binding site4821ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q18GX5 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: CF6C72C63A49F560

FASTA61866,924
        10         20         30         40         50         60 
MQFDDFANHV ITIEAESADL EITSLVSKLL TTAGNMDDKT LSTVVRFIKG TVFPAWSSQT 

        70         80         90        100        110        120 
LDIGPALLHT TIAQAAGPNV DSADVENRLA EYGEIGAVAA SYDLNGQQGL SAFTPSTPDS 

       130        140        150        160        170        180 
LTVGHVDKTL RAVASASGDG SESRRRNLLF GLFSQASSSE ARVLARLILG EMRIGVGTGT 

       190        200        210        220        230        240 
VRDAIISGFI EPAADADKKT LESREDAKSV PPASQPEITN KISGDTSPNT SESVQTKKSD 

       250        260        270        280        290        300 
PDTSSNVDPS AVVERALQVS NDYGMVATIA RNQGQAGLID ISLELGRPIQ AMLAQAADGV 

       310        320        330        340        350        360 
DAVDTWDAVA IETKFDGARV QIHTDGESVS LYSRNMEDVT DPLPEIVEFI SQKVTVPAIL 

       370        380        390        400        410        420 
DAEVVAVSDD GDPLAFQEVL RRFRRKYDID AMRESVNLNV YVFDCLHIDD ADLLDIPLRE 

       430        440        450        460        470        480 
RREKLRELFN TTDALSPFQL TTDPNVIAQA RSKALSNGHE GVMLKDPDST YNPGSRGQHW 

       490        500        510        520        530        540 
LKHKPDVETL DLVVTGAEWG EGRRANVFGT FVVSARTTAD EQQFNSLGKV ATGLTDDQLT 

       550        560        570        580        590        600 
TLTEQLRPHV RSEDGQTVMI EPAIVVEVGY EEIQRSPTYD SGFALRFPRV VGIRHDKAIS 

       610 
DVDSLSRIKH LTTGESPD 

« Hide

References

[1]"The genome of the square archaeon Haloquadratum walsbyi: life at the limits of water activity."
Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F., Pfeiffer F., Oesterhelt D.
BMC Genomics 7:169-169(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 16790 / HBSQ001.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM180088 Genomic DNA. Translation: CAJ52770.1.
RefSeqYP_658376.1. NC_008212.1.

3D structure databases

ProteinModelPortalQ18GX5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING362976.HQ2659A.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ52770; CAJ52770; HQ_2659A.
GeneID4194190.
KEGGhwa:HQ2659A.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK10747.
OMAGRPRPFQ.
ProtClustDBCLSK511253.

Enzyme and pathway databases

BioCycHWAL362976:GJSR-1760-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI2_HALWD
AccessionPrimary (citable) accession number: Q18GX5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: July 25, 2006
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families