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Protein

DNA ligase 2

Gene

lig2

Organism
Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei312 – 3121ATPUniRule annotation
Active sitei314 – 3141N6-AMP-lysine intermediateUniRule annotation
Binding sitei319 – 3191ATPUniRule annotation
Binding sitei334 – 3341ATPUniRule annotation
Binding sitei363 – 3631ATPUniRule annotation
Binding sitei403 – 4031ATPUniRule annotation
Binding sitei476 – 4761ATPUniRule annotation
Binding sitei482 – 4821ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHWAL362976:GJSR-1760-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 2UniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] 2UniRule annotation
Gene namesi
Name:lig2UniRule annotation
Ordered Locus Names:HQ_2659A
OrganismiHaloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Taxonomic identifieri362976 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloquadratum
ProteomesiUP000001975 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 618618DNA ligase 2PRO_0000365247Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi362976.HQ2659A.

Structurei

3D structure databases

ProteinModelPortaliQ18GX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiGRPRPFQ.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18GX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFDDFANHV ITIEAESADL EITSLVSKLL TTAGNMDDKT LSTVVRFIKG
60 70 80 90 100
TVFPAWSSQT LDIGPALLHT TIAQAAGPNV DSADVENRLA EYGEIGAVAA
110 120 130 140 150
SYDLNGQQGL SAFTPSTPDS LTVGHVDKTL RAVASASGDG SESRRRNLLF
160 170 180 190 200
GLFSQASSSE ARVLARLILG EMRIGVGTGT VRDAIISGFI EPAADADKKT
210 220 230 240 250
LESREDAKSV PPASQPEITN KISGDTSPNT SESVQTKKSD PDTSSNVDPS
260 270 280 290 300
AVVERALQVS NDYGMVATIA RNQGQAGLID ISLELGRPIQ AMLAQAADGV
310 320 330 340 350
DAVDTWDAVA IETKFDGARV QIHTDGESVS LYSRNMEDVT DPLPEIVEFI
360 370 380 390 400
SQKVTVPAIL DAEVVAVSDD GDPLAFQEVL RRFRRKYDID AMRESVNLNV
410 420 430 440 450
YVFDCLHIDD ADLLDIPLRE RREKLRELFN TTDALSPFQL TTDPNVIAQA
460 470 480 490 500
RSKALSNGHE GVMLKDPDST YNPGSRGQHW LKHKPDVETL DLVVTGAEWG
510 520 530 540 550
EGRRANVFGT FVVSARTTAD EQQFNSLGKV ATGLTDDQLT TLTEQLRPHV
560 570 580 590 600
RSEDGQTVMI EPAIVVEVGY EEIQRSPTYD SGFALRFPRV VGIRHDKAIS
610
DVDSLSRIKH LTTGESPD
Length:618
Mass (Da):66,924
Last modified:July 25, 2006 - v1
Checksum:iCF6C72C63A49F560
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180088 Genomic DNA. Translation: CAJ52770.1.
RefSeqiYP_658376.1. NC_008212.1.

Genome annotation databases

EnsemblBacteriaiCAJ52770; CAJ52770; HQ_2659A.
GeneIDi4194190.
KEGGihwa:HQ2659A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180088 Genomic DNA. Translation: CAJ52770.1.
RefSeqiYP_658376.1. NC_008212.1.

3D structure databases

ProteinModelPortaliQ18GX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi362976.HQ2659A.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ52770; CAJ52770; HQ_2659A.
GeneIDi4194190.
KEGGihwa:HQ2659A.

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiGRPRPFQ.

Enzyme and pathway databases

BioCyciHWAL362976:GJSR-1760-MONOMER.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the square archaeon Haloquadratum walsbyi: life at the limits of water activity."
    Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F., Pfeiffer F., Oesterhelt D.
    BMC Genomics 7:169-169(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16790 / HBSQ001.

Entry informationi

Entry nameiDNLI2_HALWD
AccessioniPrimary (citable) accession number: Q18GX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: July 25, 2006
Last modified: February 4, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.