SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q18GX5

- DNLI2_HALWD

UniProt

Q18GX5 - DNLI2_HALWD

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
DNA ligase 2
Gene
lig2, HQ_2659A
Organism
Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei312 – 3121ATP By similarity
Active sitei314 – 3141N6-AMP-lysine intermediate By similarity
Binding sitei319 – 3191ATP By similarity
Binding sitei334 – 3341ATP By similarity
Binding sitei363 – 3631ATP By similarity
Binding sitei403 – 4031ATP By similarity
Binding sitei476 – 4761ATP By similarity
Binding sitei482 – 4821ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHWAL362976:GJSR-1760-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 2 (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] 2
Gene namesi
Name:lig2
Ordered Locus Names:HQ_2659A
OrganismiHaloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Taxonomic identifieri362976 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloquadratum
ProteomesiUP000001975: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 618618DNA ligase 2UniRule annotation
PRO_0000365247Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi362976.HQ2659A.

Structurei

3D structure databases

ProteinModelPortaliQ18GX5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18GX5-1 [UniParc]FASTAAdd to Basket

« Hide

MQFDDFANHV ITIEAESADL EITSLVSKLL TTAGNMDDKT LSTVVRFIKG    50
TVFPAWSSQT LDIGPALLHT TIAQAAGPNV DSADVENRLA EYGEIGAVAA 100
SYDLNGQQGL SAFTPSTPDS LTVGHVDKTL RAVASASGDG SESRRRNLLF 150
GLFSQASSSE ARVLARLILG EMRIGVGTGT VRDAIISGFI EPAADADKKT 200
LESREDAKSV PPASQPEITN KISGDTSPNT SESVQTKKSD PDTSSNVDPS 250
AVVERALQVS NDYGMVATIA RNQGQAGLID ISLELGRPIQ AMLAQAADGV 300
DAVDTWDAVA IETKFDGARV QIHTDGESVS LYSRNMEDVT DPLPEIVEFI 350
SQKVTVPAIL DAEVVAVSDD GDPLAFQEVL RRFRRKYDID AMRESVNLNV 400
YVFDCLHIDD ADLLDIPLRE RREKLRELFN TTDALSPFQL TTDPNVIAQA 450
RSKALSNGHE GVMLKDPDST YNPGSRGQHW LKHKPDVETL DLVVTGAEWG 500
EGRRANVFGT FVVSARTTAD EQQFNSLGKV ATGLTDDQLT TLTEQLRPHV 550
RSEDGQTVMI EPAIVVEVGY EEIQRSPTYD SGFALRFPRV VGIRHDKAIS 600
DVDSLSRIKH LTTGESPD 618
Length:618
Mass (Da):66,924
Last modified:July 25, 2006 - v1
Checksum:iCF6C72C63A49F560
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180088 Genomic DNA. Translation: CAJ52770.1.
RefSeqiWP_011571886.1. NC_008212.1.
YP_658376.1. NC_008212.1.

Genome annotation databases

EnsemblBacteriaiCAJ52770; CAJ52770; HQ_2659A.
GeneIDi4194190.
KEGGihwa:HQ2659A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180088 Genomic DNA. Translation: CAJ52770.1 .
RefSeqi WP_011571886.1. NC_008212.1.
YP_658376.1. NC_008212.1.

3D structure databases

ProteinModelPortali Q18GX5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 362976.HQ2659A.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ52770 ; CAJ52770 ; HQ_2659A .
GeneIDi 4194190.
KEGGi hwa:HQ2659A.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci HWAL362976:GJSR-1760-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the square archaeon Haloquadratum walsbyi: life at the limits of water activity."
    Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F., Pfeiffer F., Oesterhelt D.
    BMC Genomics 7:169-169(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16790 / HBSQ001.

Entry informationi

Entry nameiDNLI2_HALWD
AccessioniPrimary (citable) accession number: Q18GX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: July 25, 2006
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi