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Protein

DNA ligase 2

Gene

lig2

Organism
Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei312ATPUniRule annotation1
Active sitei314N6-AMP-lysine intermediateUniRule annotation1
Binding sitei319ATPUniRule annotation1
Binding sitei334ATPUniRule annotation1
Binding sitei363ATPUniRule annotation1
Binding sitei403ATPUniRule annotation1
Binding sitei476ATPUniRule annotation1
Binding sitei482ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHWAL362976:G1G1J-1726-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 2UniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] 2UniRule annotation
Gene namesi
Name:lig2UniRule annotation
Ordered Locus Names:HQ_2659A
OrganismiHaloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Taxonomic identifieri362976 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHaloferacaceaeHaloquadratum
Proteomesi
  • UP000001975 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003652471 – 618DNA ligase 2Add BLAST618

Interactioni

Protein-protein interaction databases

STRINGi362976.HQ2659A

Structurei

3D structure databases

ProteinModelPortaliQ18GX5
SMRiQ18GX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

Q18GX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFDDFANHV ITIEAESADL EITSLVSKLL TTAGNMDDKT LSTVVRFIKG
60 70 80 90 100
TVFPAWSSQT LDIGPALLHT TIAQAAGPNV DSADVENRLA EYGEIGAVAA
110 120 130 140 150
SYDLNGQQGL SAFTPSTPDS LTVGHVDKTL RAVASASGDG SESRRRNLLF
160 170 180 190 200
GLFSQASSSE ARVLARLILG EMRIGVGTGT VRDAIISGFI EPAADADKKT
210 220 230 240 250
LESREDAKSV PPASQPEITN KISGDTSPNT SESVQTKKSD PDTSSNVDPS
260 270 280 290 300
AVVERALQVS NDYGMVATIA RNQGQAGLID ISLELGRPIQ AMLAQAADGV
310 320 330 340 350
DAVDTWDAVA IETKFDGARV QIHTDGESVS LYSRNMEDVT DPLPEIVEFI
360 370 380 390 400
SQKVTVPAIL DAEVVAVSDD GDPLAFQEVL RRFRRKYDID AMRESVNLNV
410 420 430 440 450
YVFDCLHIDD ADLLDIPLRE RREKLRELFN TTDALSPFQL TTDPNVIAQA
460 470 480 490 500
RSKALSNGHE GVMLKDPDST YNPGSRGQHW LKHKPDVETL DLVVTGAEWG
510 520 530 540 550
EGRRANVFGT FVVSARTTAD EQQFNSLGKV ATGLTDDQLT TLTEQLRPHV
560 570 580 590 600
RSEDGQTVMI EPAIVVEVGY EEIQRSPTYD SGFALRFPRV VGIRHDKAIS
610
DVDSLSRIKH LTTGESPD
Length:618
Mass (Da):66,924
Last modified:July 25, 2006 - v1
Checksum:iCF6C72C63A49F560
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180088 Genomic DNA Translation: CAJ52770.1
RefSeqiWP_011571886.1, NC_008212.1

Genome annotation databases

EnsemblBacteriaiCAJ52770; CAJ52770; HQ_2659A
GeneIDi4194190
KEGGihwa:HQ_2659A

Similar proteinsi

Entry informationi

Entry nameiDNLI2_HALWD
AccessioniPrimary (citable) accession number: Q18GX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: July 25, 2006
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health