Q18FY1 (Q18FY1_HALWD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Dihydroxy-acid dehydratase HAMAP MF_00012
Short name=DAD HAMAP MF_00012
EC=4.2.1.9 HAMAP MF_00012

Gene names

Name:	ilvD HAMAP MF_00012 EMBL CAJ53123.1
Ordered Locus Names:	HQ3021A

Organism

Haloquadratum walsbyi (strain DSM 16790) [Complete proteome] [HAMAP]

Taxonomic identifier

362976 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloquadratum

Protein attributes

Sequence length	596 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. HAMAP MF_00012
Cofactor	Binds 1 4Fe-4S cluster By similarity. HAMAP MF_00012
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. HAMAP MF_00012 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. HAMAP MF_00012
Sequence similarities	Belongs to the IlvD/Edd family. HAMAP MF_00012

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis HAMAP MF_00012
Ligand	4Fe-4S HAMAP MF_00012 Iron Iron-sulfur Metal-binding
Molecular function	Lyase HAMAP MF_00012 EMBL CAJ53123.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoleucine biosynthetic process Inferred from electronic annotation. Source: HAMAP valine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW dihydroxy-acid dehydratase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	143	1	Iron-sulfur (4Fe-4S) By similarity HAMAP MF_00012
	Metal binding	215	1	Iron-sulfur (4Fe-4S) By similarity HAMAP MF_00012

Sequences

	Sequence		Length	Mass (Da)
	Q18FY1 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: FB087F85CC384635	FASTA	596	62,416
	10 20 30 40 50 60 MSKQTHREDG ADADSPFSTE KDPDLPSTDV TEGADRAPHR AMFRAMGFDD TDLSSPMVGI 70 80 90 100 110 120 ANPAADITPC NVHLDDVADA AIEGVEDAGG MPIEFGTITI SDAISMGTEG MKASLISREV 130 140 150 160 170 180 IADSVELVAF GERMDALVTV AGCDKNLPGM MIASIRTDLP SVFLYGGSIM PGEHDGRDVT 190 200 210 220 230 240 IQNVFEGVGT YAEGDMSADE LDELERHACP GAGSCGGMFT ANTMASISEA LGMAPLGSAG 250 260 270 280 290 300 APAESTERYD IARRAGEAVL DAVANDRRPS DILSKKSFEN AIALQVAIGG STNAVLHLLA 310 320 330 340 350 360 LAAEAGVDLT IAEFDAISRR TPKIADLQPG GTKTMNDLHE IGGVPVVIRR LLDAGLFHGD 370 380 390 400 410 420 ALTVTGRTIA EELAELDLPA DSEIENENDD DYDFLYSVDD PYQTEGAIKI LTGNLAPEGG 430 440 450 460 470 480 VLKVTGDDAF HHSGPARIFE SEEDAMQYVQ TGHIESGDVI VIRNEGPQGG PGMREMLGVT 490 500 510 520 530 540 AAVVGQGHED DVALLTDGRF SGATRGPMVG HVAPEAVVGG PIALLEDGDE ITVDIPEREL 550 560 570 580 590 SVALSDAELA ERREAWDGAD RRYDTGVLAK YGSEFGSAAN GAVTNPGAKT DTQSLE

References

[1]

"The genome of the square archaeon Haloquadratum walsbyi: life at the limits of water activity." Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F., Pfeiffer F., Oesterhelt D. BMC Genomics 7:169-169(2006) [PubMed: 16820047] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 16790.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM180088 Genomic DNA. Translation: CAJ53123.1.
RefSeq	YP_658720.1. NC_008212.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q18FY1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4194158.
GenomeReviews	Gene locus HQ3021A in contig AM180088_GR.
KEGG	hwa:HQ3021A.
NMPDR	fig|362976.6.peg.2027.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04340.
HOGENOM	HBG671001.
OMA	NMPGAMI.
PhylomeDB	Q18FY1.
ProtClustDB	PRK00911.
Family and domain databases
HAMAP	MF_00012. IlvD. [Tree]
InterPro	IPR015928. Aconitase/3IPM_dehydase_swvl. IPR004404. DihydroxyA_deHydtase. IPR000581. DiOHA_6PGluconate_deHydtase. IPR020558. DiOHA_6PGluconate_deHydtase_CS. [Graphical view]
KO	K01687.
PANTHER	PTHR21000. ILVD_EDD_family. 1 hit.
Pfam	PF00920. ILVD_EDD. 1 hit. [Graphical view]
SUPFAM	SSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
TIGRFAMs	TIGR00110. IlvD. 1 hit.
PROSITE	PS00886. ILVD_EDD_1. 1 hit. PS00887. ILVD_EDD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q18FY1_HALWD

Accession

Primary (citable) accession number: Q18FY1

Entry history

Integrated into UniProtKB/TrEMBL:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)