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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHWAL362976:G1G1J-2234-MONOMER
UniPathwayiUPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:HQ_3149A
OrganismiHaloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Taxonomic identifieri362976 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHaloferacaceaeHaloquadratum
Proteomesi
  • UP000001975 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003987301 – 3162-phospho-L-lactate guanylyltransferaseAdd BLAST316

Proteomic databases

PRIDEiQ18FK8

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi362976.HQ3149A

Structurei

3D structure databases

ProteinModelPortaliQ18FK8
SMRiQ18FK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04472 Archaea
COG1920 LUCA
HOGENOMiHOG000223639
KOiK14941
OMAiFRVDYHG
OrthoDBiPOG093Z0CT7

Family and domain databases

HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF01983 CofC, 2 hits
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit

Sequencei

Sequence statusi: Complete.

Q18FK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVIVPYTDV SPKTRLNSIL TASERTAFAQ AMLYDVISTL QSNGHTVELL
60 70 80 90 100
IPTETVMQAT DQRDQETIID STGVSTEAVS TSTSTHADTT EHNAASDNYV
110 120 130 140 150
SQSPTHTLSV TPEAIMRILR DDDDPDNEAS TQERDGDKEY IDITVDTAQN
160 170 180 190 200
QIQSNQIVVT ADDRALTPAV NSCLNRLSDT ETPFSELAVV MADLALITPT
210 220 230 240 250
AIERLFAREG DIVLAPGRGG GTNAIVVRHP AFRVDYHGTS YRDHYQAATD
260 270 280 290 300
ASLSVGVVDS MRLGTDIDKP TDLPEVLLHN NGMSSVWLQS AGIELNLDDN
310
TGRVGITRKR KNEDVD
Length:316
Mass (Da):34,382
Last modified:July 25, 2006 - v1
Checksum:iE54DF4B71D55DB4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180088 Genomic DNA Translation: CAJ53249.1
RefSeqiWP_011572355.1, NC_008212.1

Genome annotation databases

EnsemblBacteriaiCAJ53249; CAJ53249; HQ_3149A
GeneIDi4193323
KEGGihwa:HQ_3149A

Similar proteinsi

Entry informationi

Entry nameiCOFC_HALWD
AccessioniPrimary (citable) accession number: Q18FK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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