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Q18F47 (MPTA_HALWD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTP cyclohydrolase MptA
EC=3.5.4.n2
Gene names
Name:mptA
Ordered Locus Names:HQ_3317A
OrganismHaloquadratum walsbyi (strain DSM 16790) [Complete proteome] [HAMAP]
Taxonomic identifier362976 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloquadratum ›

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate. HAMAP-Rule MF_01527

Cofactor

Binds 1 Fe2+ ion per subunit By similarity.

Pathway

Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis. HAMAP-Rule MF_01527

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   LigandIron
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionGTP cyclohydrolase activity

Inferred from electronic annotation. Source: HAMAP

iron ion binding

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309GTP cyclohydrolase MptA HAMAP-Rule MF_01527
PRO_0000289534

Sites

Site1571May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q18F47 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 1556BE07B2A160D3

FASTA30933,922
        10         20         30         40         50         60 
MSHQLPDIQA SRPDVTVGLS QVGVTDVDKL VKIERDGETP LVLMAEFEVF VDLPSGRKGI 

        70         80         90        100        110        120 
DMSRNMQVID ETLEAAVSGS VSRVEDMCGD VAERLLEKHE YTTTATVEMT ADLVMHEDTP 

       130        140        150        160        170        180 
ASELPTQNTI SILASATATD EGTREEIGAE VIGMTVCPCS QGMSASRARD VMHDLDIEDE 

       190        200        210        220        230        240 
TIETFLEQVP QPGHSQRGHA TLTVTADGSP DVDLIELADI ARDAMSARIY NLAKRPDEDY 

       250        260        270        280        290        300 
MTYHAHADAK FVEDCVRSMA EQVVNSFEHL DDDAVVRMKQ SNDESIHQHN AHAEREVTLE 


QLRAEVSAS

« Hide

References

[1]"The genome of the square archaeon Haloquadratum walsbyi: life at the limits of water activity."
Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F., Pfeiffer F., Oesterhelt D.
BMC Genomics 7:169-169(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 16790.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM180088 Genomic DNA. Translation: CAJ53414.1.
RefSeqYP_659006.1. NC_008212.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING362976.HQ3317A.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ53414; CAJ53414; HQ_3317A.
GeneID4193410.
KEGGhwa:HQ3317A.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280680.
KOK09007.
OMAVEDCVRE.
ProtClustDBPRK13675.

Enzyme and pathway databases

BioCycHWAL362976:GJSR-2441-MONOMER.
UniPathwayUPA00065.

Family and domain databases

Gene3D3.10.270.10. 1 hit.
HAMAPMF_01527_A. GTP_cyclohydrol_A.
InterProIPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR022840. GTP_cyclohydrolase_MptA.
IPR002042. Uricase.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00294. TIGR00294. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMPTA_HALWD
AccessionPrimary (citable) accession number: Q18F47
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 25, 2006
Last modified: May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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