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Protein

GTP cyclohydrolase MptA

Gene

mptA

Organism
Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion per subunit.UniRule annotation

Pathwayi: 5,6,7,8-tetrahydromethanopterin biosynthesis

This protein is involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei157May be catalytically importantUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciHWAL362976:G1G1J-2411-MONOMER
UniPathwayiUPA00065

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase MptAUniRule annotation (EC:3.5.4.39UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IVUniRule annotation
Gene namesi
Name:mptAUniRule annotation
Ordered Locus Names:HQ_3317A
OrganismiHaloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Taxonomic identifieri362976 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHaloferacaceaeHaloquadratum
Proteomesi
  • UP000001975 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002895341 – 309GTP cyclohydrolase MptAAdd BLAST309

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi362976.HQ3317A

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04301 Archaea
COG1469 LUCA
HOGENOMiHOG000280680
KOiK17488
OMAiHNQRGRG
OrthoDBiPOG093Z06SZ

Family and domain databases

HAMAPiMF_01527_A GTP_cyclohydrol_A, 1 hit
InterProiView protein in InterPro
IPR003801 GTP_cyclohydrolase_FolE2/MptA
IPR022840 GTP_cyclohydrolase_MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit
TIGRFAMsiTIGR00294 TIGR00294, 1 hit

Sequencei

Sequence statusi: Complete.

Q18F47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHQLPDIQA SRPDVTVGLS QVGVTDVDKL VKIERDGETP LVLMAEFEVF
60 70 80 90 100
VDLPSGRKGI DMSRNMQVID ETLEAAVSGS VSRVEDMCGD VAERLLEKHE
110 120 130 140 150
YTTTATVEMT ADLVMHEDTP ASELPTQNTI SILASATATD EGTREEIGAE
160 170 180 190 200
VIGMTVCPCS QGMSASRARD VMHDLDIEDE TIETFLEQVP QPGHSQRGHA
210 220 230 240 250
TLTVTADGSP DVDLIELADI ARDAMSARIY NLAKRPDEDY MTYHAHADAK
260 270 280 290 300
FVEDCVRSMA EQVVNSFEHL DDDAVVRMKQ SNDESIHQHN AHAEREVTLE

QLRAEVSAS
Length:309
Mass (Da):33,922
Last modified:July 25, 2006 - v1
Checksum:i1556BE07B2A160D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180088 Genomic DNA Translation: CAJ53414.1
RefSeqiWP_011572516.1, NC_008212.1

Genome annotation databases

EnsemblBacteriaiCAJ53414; CAJ53414; HQ_3317A
GeneIDi4193410
KEGGihwa:HQ_3317A

Similar proteinsi

Entry informationi

Entry nameiMPTA_HALWD
AccessioniPrimary (citable) accession number: Q18F47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 25, 2006
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health