Q18ES9 (Q18ES9_HALWD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Name:	hemB EMBL CAJ53540.1
Ordered Locus Names:	HQ3443A

Organism

Haloquadratum walsbyi (strain DSM 16790) [Complete proteome] [HAMAP]

Taxonomic identifier

362976 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloquadratum

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. RuleBase RU000515 PIRSR PIRSR001415-3
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-3 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase RuleBase RU000515 EMBL CAJ53540.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	201	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	254	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	119	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	121	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	129	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	239	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	211	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	223	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	280	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	319	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	Q18ES9 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 91B5F44EED52C598	FASTA	328	35,683
	10 20 30 40 50 60 MNIELTDRPR RLRRDGIRSL VSETSVTAQD LVAPVFIDAT TTTRTPIESM PGHERVPIED 70 80 90 100 110 120 AVTRVEEIRE TGVEAVMVFG IPAEKDERGS RAWASDGVVQ QAVRRITAET DAYVITDVCL 130 140 150 160 170 180 CEYTTHGHCG VVESDAATDP TLTVKNDKTL ELLIKTAVSH VEAGAEMVAP SSMTDGMITA 190 200 210 220 230 240 IRTALDETGH TDIPIMSYAA KYESAFYGPF RDAADGAPAF GDRRHYQMDP ANSQEAKREV 250 260 270 280 290 300 RLDVEAGADV LMVKPALAYL DIVNTVSSNF DRPVAAYNVS GEYAMVHAAA DRGWVDLEAT 310 320 AVESLIAMKR AGADLIITYF AEKLANQL

References

[1]

"The genome of the square archaeon Haloquadratum walsbyi: life at the limits of water activity." Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F., Pfeiffer F., Oesterhelt D. BMC Genomics 7:169-169(2006) [PubMed: 16820047] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 16790.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM180088 Genomic DNA. Translation: CAJ53540.1.
RefSeq	YP_659126.1. NC_008212.1.
3D structure databases
ProteinModelPortal	Q18ES9.
SMR	Q18ES9. Positions 7-328.
ModBase	Search...
Protein-protein interaction databases
STRING	Q18ES9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4194103.
GenomeReviews	Gene locus HQ3443A in contig AM180088_GR.
KEGG	hwa:HQ3443A.
NMPDR	fig|362976.6.peg.2444.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05029.
HOGENOM	HBG285270.
OMA	ADLCFCE.
PhylomeDB	Q18ES9.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q18ES9_HALWD

Accession

Primary (citable) accession number: Q18ES9

Entry history

Integrated into UniProtKB/TrEMBL:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)