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Q18ES5

- GSA_HALWD

UniProt

Q18ES5 - GSA_HALWD

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciHWAL362976:GJSR-2584-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:HQ_3447A
    OrganismiHaloquadratum walsbyi (strain DSM 16790 / HBSQ001)
    Taxonomic identifieri362976 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloquadratum
    ProteomesiUP000001975: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000382394Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei263 – 2631N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi362976.HQ3447A.

    Structurei

    3D structure databases

    ProteinModelPortaliQ18ES5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiHYPSIDM.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 2 hits.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q18ES5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDEESRALY DRALSVMPGG VNSSVRATQP YPFFIERGDG ATVIDADGTR    50
    YLDYVMGYGP LLYGHDLPEP VNAAIQSYTS EGPMYGAPTP IEVEHAEFVA 100
    RHVPSVEMIR FVNSGTEATV SAVRLARGYT GRDKIVVMKG GYHGAQESTL 150
    VEGDPMHVEP STPGIPSSFA KHTLPVPFND LEAITTVFET HGEDIAAVLT 200
    EPILANNGIV RPVDGYLEHL RSLTTEHNSL LIFDEVITGF RVGGLGCAQS 250
    KFGVTPDVTT FGKIIGGGFP VGAIGGRADI IEHFTPSGDV FQSGTFSGHP 300
    VTMAAGYESL KYAAENDVYD HVNRLGERLR GGITDIATDQ SPSAIVVGLD 350
    SMFKTVFERE GSTTDDGDVC SAGCEQRESC MRYDDCPKTG ADVSSAETER 400
    WERIFWQEMR DHNIFLTANQ FESQFVSYAH TDEDIDRTLE AYKSAL 446
    Length:446
    Mass (Da):48,496
    Last modified:July 25, 2006 - v1
    Checksum:iC72505354DAC3ADE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180088 Genomic DNA. Translation: CAJ53544.1.
    RefSeqiWP_011572639.1. NC_008212.1.
    YP_659130.1. NC_008212.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ53544; CAJ53544; HQ_3447A.
    GeneIDi4194107.
    KEGGihwa:HQ3447A.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180088 Genomic DNA. Translation: CAJ53544.1 .
    RefSeqi WP_011572639.1. NC_008212.1.
    YP_659130.1. NC_008212.1.

    3D structure databases

    ProteinModelPortali Q18ES5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 362976.HQ3447A.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ53544 ; CAJ53544 ; HQ_3447A .
    GeneIDi 4194107.
    KEGGi hwa:HQ3447A.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi HYPSIDM.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci HWAL362976:GJSR-2584-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 2 hits.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the square archaeon Haloquadratum walsbyi: life at the limits of water activity."
      Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F., Pfeiffer F., Oesterhelt D.
      BMC Genomics 7:169-169(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 16790 / HBSQ001.

    Entry informationi

    Entry nameiGSA_HALWD
    AccessioniPrimary (citable) accession number: Q18ES5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3