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Q18ER3

- DP2L_HALWD

UniProt

Q18ER3 - DP2L_HALWD

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Protein

DNA polymerase II large subunit

Gene
polC, polA2, HQ_3461A
Organism
Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase By similarity.UniRule annotation

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation
Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
  3. endonuclease activity Source: UniProtKB-KW
  4. exonuclease activity Source: UniProtKB-KW

GO - Biological processi

  1. DNA catabolic process Source: InterPro
  2. intein-mediated protein splicing Source: InterPro
  3. intron homing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Endonuclease, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication, Intron homing

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciHWAL362976:GJSR-2597-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase II large subunit (EC:2.7.7.7)
Short name:
Pol II
Cleaved into the following 2 chains:
Alternative name(s):
Hwa pol II 1 intein
Alternative name(s):
Hwa pol II 2 intein
Gene namesi
Name:polC
Synonyms:polA2
Ordered Locus Names:HQ_3461A
OrganismiHaloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Taxonomic identifieri362976 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloquadratum
ProteomesiUP000001975: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 966966DNA polymerase II large subunit, 1st part Reviewed predictionPRO_0000294680Add
BLAST
Chaini967 – 1495529Hwa polC 1 intein Reviewed predictionPRO_0000294681Add
BLAST
Chaini1496 – 152429DNA polymerase II large subunit, 2nd part Reviewed predictionPRO_0000294682Add
BLAST
Chaini1525 – 2068544Hwa polC 2 intein Reviewed predictionPRO_0000294683Add
BLAST
Chaini2069 – 2289221DNA polymerase II large subunit, 3rd part Reviewed predictionPRO_0000294684Add
BLAST

Post-translational modificationi

This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation Reviewed prediction.UniRule annotation

Keywords - PTMi

Autocatalytic cleavage, Protein splicing

Interactioni

Subunit structurei

Heterodimer of a large subunit and a small subunit By similarity.

Protein-protein interaction databases

STRINGi362976.HQ3461A.

Structurei

3D structure databases

ProteinModelPortaliQ18ER3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1222 – 1367146DOD-type homing endonuclease 1Add
BLAST
Domaini1755 – 1911157DOD-type homing endonuclease 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1933.
KOiK02322.
OMAiEYPWSAA.

Family and domain databases

Gene3Di2.170.16.10. 4 hits.
3.10.28.10. 2 hits.
HAMAPiMF_00324. DNApol_II_L_arch.
InterProiIPR028992. Hedgehog/Intein_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR027434. Homing_endonucl.
IPR006142. INTEIN.
IPR004042. Intein_endonuc.
IPR006141. Intein_splice_site.
IPR004475. PolC_DP2.
IPR016033. PolC_DP2_N.
[Graphical view]
PfamiPF03833. PolC_DP2. 1 hit.
[Graphical view]
PRINTSiPR00379. INTEIN.
SMARTiSM00305. HintC. 2 hits.
SM00306. HintN. 2 hits.
[Graphical view]
SUPFAMiSSF51294. SSF51294. 4 hits.
SSF55608. SSF55608. 2 hits.
TIGRFAMsiTIGR01445. intein_Nterm. 1 hit.
TIGR00354. polC. 1 hit.
PROSITEiPS50819. INTEIN_ENDONUCLEASE. 2 hits.
PS50817. INTEIN_N_TER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q18ER3-1 [UniParc]FASTAAdd to Basket

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MRDADKQYFE TLESHLEQAF ARARQAKGQG YDPKPEVEIP VARDMADRVE     50
NILAIPDVAE RIRELDDERS REEVALELVT DFVEGTVGDY DTREGKIEGA 100
VRTAVALLTE GVVAAPIEGI DRVEILSDDD GSEFVNVYYA GPIRSAGGTA 150
QALSVLVADY ARSLLDIDEY SARTDETERY AEEVSLYDRE TGLQYSPKDK 200
ETKFITKHMP IMLDGEATGN EEVSGYRDLE RVDTNAARGG MCLVLAEGIA 250
LKAPKIQRYT RQLAEVEWPW LQDLIDDTIG SDEHSNNSVK NGEADIVKTD 300
KDTNESETED GIDNDDYNDS GLEPANSPRA DATNKYLRDL IAGRPVFGHP 350
SAAGAFRLRY GRARNHGFAT AGVHPATMHI VDDFIATGTQ LKTERPGKAG 400
GVVPVDSIKG PTVRLANGDV RCINDPEEAE KLQNGVEKIL DLGEYLVNFG 450
EFIENNHPLA PAAYVFEWWI QEFEASNADV QALRDDPTVD LESPTFENAM 500
RWAKKHDIPL HPAYTYLWHD ISVTEFDHLA DAVAAGEITM NEVSDTNSAS 550
GNTSLRANTN TDDTLTIDTT PAIRETMERL LIEHHQDSDS IHIPAWRALA 600
LSLGIKIESD NDTGIGDRMW SLTDLSKHAR KQDDGKSAIA AVNEVAPFQV 650
RERAPTRIGS RMGRPEKSED RDLSPAVHTL FPIGEAGGNQ RNLSDAAQSF 700
GDNTERGQIS VQLGKRRCPY CETVGFELQC AECGRHTEPQ FVCRECESVL 750
SPDESGRVHC DRCERDVTSA EWQDIDLHQR YRDALDRVDE RESSFEILKG 800
VKGLTSSNKT PEPLEKGILR AKHGVSSFKD GTVRYDMTDL PVTAVRPKEL 850
DVTAAHFREL GYQTDINGNP LQFDDQLVEL KVQDIVLPDG AAEHMMKTAD 900
FVDDLLEQFY ELNQFYQIDE RDDLIGELVF GMAPHTSAAV VGRIVGFTSA 950
AVGYAHPYFH AAKRRNCFHP ETKIWFRDTD NEWHHETIQT FVEDRLDDPE 1000
IDAVGTLVQE VDDNTDREIS VPSIDDNGNE RLQSVTAVSK HRAPNHLVQI 1050
ETISGREITI TPDHEMHIFE QGNLVSKQAS KITSGEYAVI PKRLQTISPS 1100
SHTPQHDLLR EFLTRDELTA DRLIIHTSDP VRLCNRVFPE EVTSCKDAVE 1150
IMQNTACHLD KNKETLIGWL GEGRIPVALL RGFVETDEAL LMSIPDDVQI 1200
GLRGEKVRID RHIGFTEELT SLLGYYAAAG IVHTQTNPIS YESAQQEQSR 1250
ITFYNIDTQT QTDLLNALNS VFEIEPIQYN LDGEILGVPG ELIRRVFDTV 1300
FDVGTQPSHK RIPQALFDAS ESHITSYLRC FFSTHDSLTT DTRDISATTV 1350
SREFKEDIIA ALRRLGITAE VTTQQSRSVP EVLPDWYAID DITHHDADNS 1400
LNLTRSYVIS IASSDAVTLQ RDRQAQEQIK YDAQGLIANN NAIHQSRQVT 1450
DGGRKDYITE PITDIEYVDA DIDYTYCLTV SETHSLIVND LSQKQCDGDE 1500
DCVMLLMDGL LNFSREYLPD KRGGSVAADS RLVAVSPDDK IVFTTIEDFW 1550
KKLNTPIERN GKFRKRTCVS EGWQTYAFDE NHEASLRPIE KAIRYTADES 1600
EQLRRITTQL GRSLDITDEH SLFRYDDGIE EVAGDDLTAG DIIVAPRTLD 1650
VEVTQTTLDL SEYIHDNERC PSEQTGSGEL NLASKSAISD SRNKETPGVT 1700
HNILPQRSKF TDEMTTLSPT AVGGLESEQN ETLRVGESTG AIERYINVDD 1750
SFGWLLGQFI AQRSISTDAL TMTVHTAAEK HAERIVATSD SVFGIKPTVN 1800
SIERGYEIVF PSVFDTIVSG LTAKEQSEPE QDVDHTHTDE IGIPECILHA 1850
PDDIVLSFLQ GFILAENAQR KGNAASEASE MVSESETTVT LETPSVGVKD 1900
GLVFLCHRLG VITDISEKSG EEYSVHFEES RYTVSIATEG KTNPLDQILN 1950
GERPTMPEGV SVPVPDALLT IHESIANSPH IDQVIPDTVV QQETVSLETL 2000
QSLLTGLSTV DLPAQLEAKR DELTLLTEGD LSYLRVESVE CVDYDGYLYD 2050
LQVGGEPVFT ANWLYAHNSM DAPLVMSSRI DPSEIDDEAH NMDIVRQYPR 2100
EFYEATRRME DPDEWEEEVT IAEEYLDTDN EYTGFNHTHD TTDIAAGPDL 2150
SAYKTLDSMM DKMDAQLELA RKLRAVDETD VAERVIEYHF LPDLIGNLRA 2200
FSRQQTRCLD CGESYRRMPL TGECRECGGR VNLTVHEGSV NKYMDTAIHI 2250
AEEFDCREYT KQRLEVLERS LESIFEDDTN KQSGIADFM 2289
Length:2,289
Mass (Da):255,812
Last modified:July 25, 2006 - v1
Checksum:iA5E70294203AFF05
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180088 Genomic DNA. Translation: CAJ53557.1.
RefSeqiWP_011572651.1. NC_008212.1.
YP_659142.1. NC_008212.1.

Genome annotation databases

EnsemblBacteriaiCAJ53557; CAJ53557; HQ_3461A.
GeneIDi4194482.
KEGGihwa:HQ3461A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180088 Genomic DNA. Translation: CAJ53557.1 .
RefSeqi WP_011572651.1. NC_008212.1.
YP_659142.1. NC_008212.1.

3D structure databases

ProteinModelPortali Q18ER3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 362976.HQ3461A.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ53557 ; CAJ53557 ; HQ_3461A .
GeneIDi 4194482.
KEGGi hwa:HQ3461A.

Phylogenomic databases

eggNOGi COG1933.
KOi K02322.
OMAi EYPWSAA.

Enzyme and pathway databases

BioCyci HWAL362976:GJSR-2597-MONOMER.

Family and domain databases

Gene3Di 2.170.16.10. 4 hits.
3.10.28.10. 2 hits.
HAMAPi MF_00324. DNApol_II_L_arch.
InterProi IPR028992. Hedgehog/Intein_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR027434. Homing_endonucl.
IPR006142. INTEIN.
IPR004042. Intein_endonuc.
IPR006141. Intein_splice_site.
IPR004475. PolC_DP2.
IPR016033. PolC_DP2_N.
[Graphical view ]
Pfami PF03833. PolC_DP2. 1 hit.
[Graphical view ]
PRINTSi PR00379. INTEIN.
SMARTi SM00305. HintC. 2 hits.
SM00306. HintN. 2 hits.
[Graphical view ]
SUPFAMi SSF51294. SSF51294. 4 hits.
SSF55608. SSF55608. 2 hits.
TIGRFAMsi TIGR01445. intein_Nterm. 1 hit.
TIGR00354. polC. 1 hit.
PROSITEi PS50819. INTEIN_ENDONUCLEASE. 2 hits.
PS50817. INTEIN_N_TER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the square archaeon Haloquadratum walsbyi: life at the limits of water activity."
    Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F., Pfeiffer F., Oesterhelt D.
    BMC Genomics 7:169-169(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16790 / HBSQ001.

Entry informationi

Entry nameiDP2L_HALWD
AccessioniPrimary (citable) accession number: Q18ER3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 25, 2006
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. Intein-containing proteins
    List of intein-containing protein entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi