Q18DY7 (AROD_HALWD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	HQ1154A

Organism

Haloquadratum walsbyi (strain DSM 16790) [Complete proteome] [HAMAP]

Taxonomic identifier

362976 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloquadratum

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 245	245	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_0000325532
Sites
	Active site	132	1	Proton acceptor By similarity
	Active site	158	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q18DY7 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 753703E36EE9FC04	FASTA	245	26,279
	10 20 30 40 50 60 MTSTQAVSFD TFQLAAATAD LSDESAASDY ADIVEFRLDL AYADTSLPDP LTAISAYDHS 70 80 90 100 110 120 SSLPLIVTNR PEWEGGAYDG ETIDRLEMLI TAAKHDAVIA VDIELETLKS QHGKKVARDI 130 140 150 160 170 180 RNSGAVIIAS THDFTSTPQQ SVLHERLHTA AQLGDIGKLA VTAQTHRDAL RVLAATEQAS 190 200 210 220 230 240 QWGDTVATMA MGALGQHTRV VAPLYGSRIG YAPVNPTDAT APGQYDIKTL SEMIDTLTHT KVEDD

References

[1]

"The genome of the square archaeon Haloquadratum walsbyi: life at the limits of water activity." Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F., Pfeiffer F., Oesterhelt D. BMC Genomics 7:169-169(2006) [PubMed: 16820047] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 16790.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM180088 Genomic DNA. Translation: CAJ51284.1.
RefSeq	YP_656939.1. NC_008212.1.
3D structure databases
ProteinModelPortal	Q18DY7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q18DY7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4193721.
GenomeReviews	Gene locus HQ1154A in contig AM180088_GR.
KEGG	hwa:HQ1154A.
NMPDR	fig|362976.6.peg.157.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG12575.
HOGENOM	HBG732926.
OMA	EFRMDLA.
PhylomeDB	Q18DY7.
Enzyme and pathway databases
BioCyc	HWAL362976:HQ1154A-MONOMER.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_HALWD

Accession

Primary (citable) accession number: Q18DY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	July 25, 2006
Last modified:	November 16, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program