Q18DR8 (Q18DR8_HALWD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
NH(3)-dependent NAD(+) synthetase HAMAP MF_00193 RuleBase RU003812
EC=6.3.1.5 HAMAP MF_00193 RuleBase RU003812

Gene names

Name:	nadE HAMAP MF_00193 EMBL CAJ51221.1
Ordered Locus Names:	HQ1091A

Organism

Haloquadratum walsbyi (strain DSM 16790) [Complete proteome] [HAMAP]

Taxonomic identifier

362976 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloquadratum

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. HAMAP MF_00193 RuleBase RU003812
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1. RuleBase RU004252 HAMAP MF_00193
Sequence similarities	Belongs to the NAD synthetase family. HAMAP MF_00193 RuleBase RU003811

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_00193 RuleBase RU003811 NAD HAMAP MF_00193 RuleBase RU003811 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00193 RuleBase RU003811 EMBL CAJ51221.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP NAD+ synthase (glutamine-hydrolyzing) activity Inferred from electronic annotation. Source: InterPro NAD+ synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	47 – 54	8	ATP By similarity HAMAP MF_00193
Sites
	Active site	49	1	By similarity HAMAP MF_00193

Sequences

	Sequence		Length	Mass (Da)
	Q18DR8 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: CE7A5C8DC1BD7149	FASTA	275	29,662
	10 20 30 40 50 60 MQQSVLSTDA PLDLRLSPEE LETVESHVSQ FITDIVADAG ADGAVLGLSG GIDSTTVADM 70 80 90 100 110 120 AVNALGAENV HGLVMPSEVN DDANMSDAEW VAEELDIPYE VIEIQPIAES FFEAIPEAAD 130 140 150 160 170 180 DQMAVGNVYV RTRAVLNYFL ANHENKIVLG TGNRSEALTG YYTKYGDQAV DCNPIGNLYK 190 200 210 220 230 240 QQVRQLAASV GIPEELVMKT PSAGMWVGQT DEEELGLGYD TVDAILALHV DGPLSVDATV 250 260 270 RQLDVTSEDI TRVVELYEKS KHKRQMPPAP PSLSL

References

[1]

"The genome of the square archaeon Haloquadratum walsbyi: life at the limits of water activity." Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F., Pfeiffer F., Oesterhelt D. BMC Genomics 7:169-169(2006) [PubMed: 16820047] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 16790.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM180088 Genomic DNA. Translation: CAJ51221.1.
RefSeq	YP_656877.1. NC_008212.1.
3D structure databases
ProteinModelPortal	Q18DR8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q18DR8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4194329.
GenomeReviews	Gene locus HQ1091A in contig AM180088_GR.
KEGG	hwa:HQ1091A.
NMPDR	fig|362976.6.peg.92.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG08797.
HOGENOM	HBG351567.
OMA	IDERIVS.
PhylomeDB	Q18DR8.
ProtClustDB	PRK13980.
Family and domain databases
HAMAP	MF_00193. NadE. [Tree]
InterPro	IPR022310. NAD/GMP_synthase. IPR003694. NAD_synthase. IPR022926. NH(3)-dep_NAD(+)_synth. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01916.
Pfam	PF02540. NAD_synthase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00552. NadE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q18DR8_HALWD

Accession

Primary (citable) accession number: Q18DR8

Entry history

Integrated into UniProtKB/TrEMBL:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)