Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

IMP cyclohydrolase

Gene

purO

Organism
Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.UniRule annotation

Catalytic activityi

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. IMP cyclohydrolase (purO)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPurine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purOUniRule annotation
Ordered Locus Names:HQ_1006A
OrganismiHaloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Taxonomic identifieri362976 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHaloferacaceaeHaloquadratum
Proteomesi
  • UP000001975 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003491591 – 195IMP cyclohydrolaseAdd BLAST195

Interactioni

Protein-protein interaction databases

STRINGi362976.HQ1006A.

Structurei

3D structure databases

ProteinModelPortaliQ18DI6.
SMRiQ18DI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal IMP cyclohydrolase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04727. Archaea.
COG3363. LUCA.
HOGENOMiHOG000015497.
KOiK11176.
OMAiYNTPRIA.
OrthoDBiPOG093Z0CY5.

Family and domain databases

Gene3Di3.60.20.20. 1 hit.
HAMAPiMF_00705. IMP_cyclohydrol. 1 hit.
InterProiView protein in InterPro
IPR010191. IMP_cyclohydrolase.
IPR020600. IMP_cyclohydrolase-like.
IPR036795. IMP_cyclohydrolase-like_sf.
PfamiView protein in Pfam
PF07826. IMP_cyclohyd. 1 hit.
PIRSFiPIRSF004866. IMP_cclhdr_arch. 1 hit.
SUPFAMiSSF75569. SSF75569. 1 hit.
TIGRFAMsiTIGR01922. purO_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18DI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLGRFIIIG ETTAVYRVSS RSYPNRQIIS RDNMLTVVPT SEAAQTNNPY
60 70 80 90 100
VSYNCMRQGG EKIVIGNGSH VDPIAEKIDR GYPARDALAE ALLALDYEKD
110 120 130 140 150
DYNTPRIAGI VGSSSYVGII RQDAVIIRSI SEPTLVSTYE NDAPTTAQLS
160 170 180 190
LKGDIEEIAQ KAYELEYEHP VCAAAVTHQG QGESGDIVAQ IYNGK
Length:195
Mass (Da):21,320
Last modified:July 25, 2006 - v1
Checksum:i8DA09F3562DC1FE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180088 Genomic DNA. Translation: CAJ51136.1.
RefSeqiWP_011570303.1. NC_008212.1.

Genome annotation databases

EnsemblBacteriaiCAJ51136; CAJ51136; HQ_1006A.
GeneIDi4194534.
KEGGihwa:HQ_1006A.

Similar proteinsi

Entry informationi

Entry nameiPURO_HALWD
AccessioniPrimary (citable) accession number: Q18DI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 25, 2006
Last modified: October 25, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families