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Protein

Translational regulator CsrA

Gene

csrA

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor, RNA-binding
Biological processBacterial flagellum biogenesis, Translation regulation

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-337-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translational regulator CsrAUniRule annotation
Gene namesi
Name:csrAUniRule annotation
Ordered Locus Names:CD630_02340
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000233721 – 70Translational regulator CsrAAdd BLAST70

Interactioni

Subunit structurei

Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.UniRule annotation

Protein-protein interaction databases

STRINGi272563.CD0234.

Structurei

3D structure databases

ProteinModelPortaliQ18CX3.
SMRiQ18CX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CsrA/RsmA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105VM8. Bacteria.
COG1551. LUCA.
HOGENOMiHOG000020767.
KOiK03563.
OMAiIHRKEVY.

Family and domain databases

Gene3Di3.30.70.1680. 1 hit.
HAMAPiMF_00167. CsrA. 1 hit.
InterProiView protein in InterPro
IPR003751. CsrA.
IPR036107. CsrA_sf.
PANTHERiPTHR34984. PTHR34984. 1 hit.
PfamiView protein in Pfam
PF02599. CsrA. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009007. CsrA. 1 hit.
SUPFAMiSSF117130. SSF117130. 1 hit.
TIGRFAMsiTIGR00202. csrA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18CX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVISRKKDE AVLIGDNIEV KVVGVDGNNI KLAISAPNNI SILRKEIYEK
60 70
VKNENIKATN KNIKILKSLK
Length:70
Mass (Da):7,800
Last modified:July 25, 2006 - v1
Checksum:i1D004D5736384260
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ67055.1.
RefSeqiWP_003425267.1. NZ_CP010905.2.
YP_001086702.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ67055; CAJ67055; CD630_02340.
GeneIDi31351775.
4916752.
KEGGicdf:CD630_02340.
pdc:CDIF630_00356.
PATRICifig|272563.120.peg.250.

Similar proteinsi

Entry informationi

Entry nameiCSRA_PEPD6
AccessioniPrimary (citable) accession number: Q18CX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome