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Q18CW0

- PUR9_PEPD6

UniProt

Q18CW0 - PUR9_PEPD6

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciCDIF272563:GJFE-335-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:CD630_02230
    OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
    Taxonomic identifieri272563 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
    ProteomesiUP000001978: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 510510Bifunctional purine biosynthesis protein PurHPRO_1000018878Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272563.CD0223.

    Structurei

    3D structure databases

    ProteinModelPortaliQ18CW0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiHRRAHAC.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q18CW0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKRALISVT DKTGVVEFAK ELNKLDYEII STGNTFKTLK ENGVNVMQVE    50
    DVTNFPEILD GRVKTLNPYI HGGILYKRDK ESHVETVNEH KIHSIDLVAV 100
    NLYDFEGTLK AGKSHDEIIE NIDIGGPSMI RSAAKNYKDV IVVVDIKDYD 150
    SIIEKLKTDT MTLEDRKKLS YKAFSTTGRY DALISSYFAG EVGDTYPDIL 200
    NLTFQKEQTL RYGENPHQNG FLYSQSNAKN PILNYEQLGG KELSFNNLND 250
    LHGCLEVMRE FKDSEEVVSV AIKHANSCGV GLGKDAFEAY TKCYEADKVS 300
    IFGGIVGITS TIDKATAEKL NEIFLEIVVA YDFEPEALEI LKQKKNLRIL 350
    KLAKIENSLQ PYEMKYLDGK LLIQDRNNIL AEKSENVTKE KPTDAQLKDM 400
    EFGMRVVKNM KSNAIAIVKN GQTLALGCGQ TSRIWALKNA LENNKDKDFT 450
    GAVLASDAFF PFDDCVTLAH EYGISAVVQP GGSIKDKDSI EACDKYDMVM 500
    VFTGIRHFKH 510
    Length:510
    Mass (Da):57,107
    Last modified:July 25, 2006 - v1
    Checksum:i44E6415D06DE2528
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180355 Genomic DNA. Translation: CAJ67044.1.
    RefSeqiYP_001086691.1. NC_009089.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ67044; CAJ67044; CD630_02230.
    GeneIDi4916698.
    KEGGicdf:CD630_02230.
    PATRICi19438689. VBICloDif38397_0241.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180355 Genomic DNA. Translation: CAJ67044.1 .
    RefSeqi YP_001086691.1. NC_009089.1.

    3D structure databases

    ProteinModelPortali Q18CW0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272563.CD0223.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ67044 ; CAJ67044 ; CD630_02230 .
    GeneIDi 4916698.
    KEGGi cdf:CD630_02230.
    PATRICi 19438689. VBICloDif38397_0241.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi HRRAHAC.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci CDIF272563:GJFE-335-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 630.

    Entry informationi

    Entry nameiPUR9_PEPD6
    AccessioniPrimary (citable) accession number: Q18CW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3