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Q18CW0

- PUR9_PEPD6

UniProt

Q18CW0 - PUR9_PEPD6

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Protein

Bifunctional purine biosynthesis protein PurH

Gene
purH, CD630_02230
Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-335-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:CD630_02230
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
ProteomesiUP000001978: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Bifunctional purine biosynthesis protein PurHUniRule annotationPRO_1000018878Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272563.CD0223.

Structurei

3D structure databases

ProteinModelPortaliQ18CW0.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiHRRAHAC.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18CW0-1 [UniParc]FASTAAdd to Basket

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MSKRALISVT DKTGVVEFAK ELNKLDYEII STGNTFKTLK ENGVNVMQVE    50
DVTNFPEILD GRVKTLNPYI HGGILYKRDK ESHVETVNEH KIHSIDLVAV 100
NLYDFEGTLK AGKSHDEIIE NIDIGGPSMI RSAAKNYKDV IVVVDIKDYD 150
SIIEKLKTDT MTLEDRKKLS YKAFSTTGRY DALISSYFAG EVGDTYPDIL 200
NLTFQKEQTL RYGENPHQNG FLYSQSNAKN PILNYEQLGG KELSFNNLND 250
LHGCLEVMRE FKDSEEVVSV AIKHANSCGV GLGKDAFEAY TKCYEADKVS 300
IFGGIVGITS TIDKATAEKL NEIFLEIVVA YDFEPEALEI LKQKKNLRIL 350
KLAKIENSLQ PYEMKYLDGK LLIQDRNNIL AEKSENVTKE KPTDAQLKDM 400
EFGMRVVKNM KSNAIAIVKN GQTLALGCGQ TSRIWALKNA LENNKDKDFT 450
GAVLASDAFF PFDDCVTLAH EYGISAVVQP GGSIKDKDSI EACDKYDMVM 500
VFTGIRHFKH 510
Length:510
Mass (Da):57,107
Last modified:July 25, 2006 - v1
Checksum:i44E6415D06DE2528
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180355 Genomic DNA. Translation: CAJ67044.1.
RefSeqiYP_001086691.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ67044; CAJ67044; CD630_02230.
GeneIDi4916698.
KEGGicdf:CD630_02230.
PATRICi19438689. VBICloDif38397_0241.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180355 Genomic DNA. Translation: CAJ67044.1 .
RefSeqi YP_001086691.1. NC_009089.1.

3D structure databases

ProteinModelPortali Q18CW0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272563.CD0223.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ67044 ; CAJ67044 ; CD630_02230 .
GeneIDi 4916698.
KEGGi cdf:CD630_02230.
PATRICi 19438689. VBICloDif38397_0241.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi HRRAHAC.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci CDIF272563:GJFE-335-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 630.

Entry informationi

Entry nameiPUR9_PEPD6
AccessioniPrimary (citable) accession number: Q18CW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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