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Protein

60 kDa chaperonin

Gene

groL

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-299-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation
Ordered Locus Names:CD630_01940
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002568951 – 54260 kDa chaperoninAdd BLAST542

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

STRINGi272563.CD0194.

Structurei

3D structure databases

ProteinModelPortaliQ18CT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
HOGENOMiHOG000076290.
KOiK04077.
OMAiKKQMDET.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18CT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEIKFSEE TRRALEAGVN KLADTVKVTL GPKGRNVILD KKFGSPLITN
60 70 80 90 100
DGVTIAKEIE LEDRFENMGA QLVKEVATKT NDVAGDGTTT ATVLAQAIIR
110 120 130 140 150
EGLKNVTAGA NPILLRKGIQ KAVTVAVEEL KNQSRIVETQ EAISQVASIS
160 170 180 190 200
AGDEEVGKLI AEAMEIVGKD GVITVEESQT MNTELDAVEG MQFDRGFVSA
210 220 230 240 250
YMVTDVDKME AVLNDPYILI TDKKISNIQE LLPVLEQIVQ QGKKLLIIAE
260 270 280 290 300
DVEGEALSTL VVNKLRGTFD VVAVKAPGFG DRRKEMLQDI AILTGAQVIS
310 320 330 340 350
EELGYDLKEA DLSMLGRASS VKVTKESTTI VDGSGDKKAI EDRVTQIKHQ
360 370 380 390 400
VEQTTSDFDR EKLMERLAKL AGGVAVVKVG AATEVELKER KLRIEDALNA
410 420 430 440 450
TRAAVEEGIV AGGGTAFVSV IPAIGTLIES LEGEVKLGAQ IVKKALEEPL
460 470 480 490 500
RQIAINAGLE GAVIVQNVVN SEAETGFDAL NEKYVNMIEA GIVDPTKVSR
510 520 530 540
SALQNAASIA STFLTTEAAV ADLPEKEDAG MPGMGGGMPG MM
Length:542
Mass (Da):57,771
Last modified:July 25, 2006 - v1
Checksum:i63443E283F7A0FE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ67016.1.
RefSeqiWP_003435012.1. NZ_CP010905.1.
YP_001086664.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ67016; CAJ67016; CD630_01940.
GeneIDi4915463.
KEGGicdf:CD630_01940.
pdc:CDIF630_00315.
PATRICi19438631. VBICloDif38397_0212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ67016.1.
RefSeqiWP_003435012.1. NZ_CP010905.1.
YP_001086664.1. NC_009089.1.

3D structure databases

ProteinModelPortaliQ18CT5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD0194.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ67016; CAJ67016; CD630_01940.
GeneIDi4915463.
KEGGicdf:CD630_01940.
pdc:CDIF630_00315.
PATRICi19438631. VBICloDif38397_0212.

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
HOGENOMiHOG000076290.
KOiK04077.
OMAiKKQMDET.

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-299-MONOMER.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCH60_PEPD6
AccessioniPrimary (citable) accession number: Q18CT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 25, 2006
Last modified: November 2, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.