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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Carbamoyl-phosphate synthase large chain (carB2), Carbamoyl-phosphate synthase small chain (carA), Carbamoyl-phosphate synthase small chain (carA1), Carbamoyl-phosphate synthase large chain (carB1)
  2. Aspartate carbamoyltransferase (pyrB)
  3. Dihydroorotase (pyrC)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-289-MONOMER
UniPathwayiUPA00070; UER00116

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
Alternative name(s):
Aspartate transcarbamylaseUniRule annotation
Short name:
ATCaseUniRule annotation
Gene namesi
Name:pyrBUniRule annotation
Ordered Locus Names:CD630_01840
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003210911 – 306Aspartate carbamoyltransferaseAdd BLAST306

Proteomic databases

PRIDEiQ18CS8

Interactioni

Protein-protein interaction databases

STRINGi272563.CD0184

Structurei

3D structure databases

ProteinModelPortaliQ18CS8
SMRiQ18CS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXT Bacteria
COG0540 LUCA
HOGENOMiHOG000022685
KOiK00609
OMAiWCDVANM

Family and domain databases

Gene3Di3.40.50.1370, 3 hits
HAMAPiMF_00001 Asp_carb_tr, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR002082 Asp_carbamoyltransf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
PANTHERiPTHR11405:SF16 PTHR11405:SF16, 1 hit
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00101 ATCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00670 asp_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q18CS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKSRNLIQP EDFSIEEIDE ILELAQKIID NPSKYSRICE GKLLATLFYE
60 70 80 90 100
PSTRTRLSFE SAMNRLGGRV VGFSEPNSSS ASKGETLGDT MRIVSGYVDI
110 120 130 140 150
IAMRHPQSGA ASEAARYTEV PFINAGDGKN QHPTQTLTDL LTIKSLKGTL
160 170 180 190 200
ESHTIGLCGD LKYGRTVHSL VKAMARYKNT KFVFIAPEEL KMPDYIKEAI
210 220 230 240 250
KGHAYYETNN LDDVIGSLDV LYMTRVQQER FEDKSEYERL KNYYILNKAK
260 270 280 290 300
LEKASKDMLV MHPLPRVNEI DIDVDSDDRA VYFKQAKYGM YVRMALIIKL

LGINED
Length:306
Mass (Da):34,700
Last modified:July 25, 2006 - v1
Checksum:i5758EF000FE65FC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA Translation: CAJ67006.1
RefSeqiWP_003434504.1, NZ_CP010905.2
YP_001086654.1, NC_009089.1

Genome annotation databases

EnsemblBacteriaiCAJ67006; CAJ67006; CD630_01840
GeneIDi31351726
4915020
KEGGicdf:CD630_01840
pdc:CDIF630_00305
PATRICifig|272563.120.peg.199

Similar proteinsi

Entry informationi

Entry nameiPYRB_PEPD6
AccessioniPrimary (citable) accession number: Q18CS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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