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Protein

50S ribosomal protein L22

Gene

rplV

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).UniRule annotation
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-132-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L22UniRule annotation
Gene namesi
Name:rplVUniRule annotation
Ordered Locus Names:CD630_00780
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000525601 – 11150S ribosomal protein L22Add BLAST111

Proteomic databases

PRIDEiQ18CG1

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit.UniRule annotation

Protein-protein interaction databases

STRINGi272563.CD0078

Structurei

3D structure databases

ProteinModelPortaliQ18CG1
SMRiQ18CG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the universal ribosomal protein uL22 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105KAP Bacteria
COG0091 LUCA
HOGENOMiHOG000205046
KOiK02890
OMAiPQGRAHR

Family and domain databases

CDDicd00336 Ribosomal_L22, 1 hit
Gene3Di3.90.470.10, 1 hit
HAMAPiMF_01331_B Ribosomal_L22_B, 1 hit
InterProiView protein in InterPro
IPR001063 Ribosomal_L22
IPR018260 Ribosomal_L22/L17_CS
IPR036394 Ribosomal_L22/L17_sf
IPR005727 Ribosomal_L22_bac/chlpt-type
PANTHERiPTHR13501 PTHR13501, 1 hit
PfamiView protein in Pfam
PF00237 Ribosomal_L22, 1 hit
SUPFAMiSSF54843 SSF54843, 1 hit
TIGRFAMsiTIGR01044 rplV_bact, 1 hit
PROSITEiView protein in PROSITE
PS00464 RIBOSOMAL_L22, 1 hit

Sequencei

Sequence statusi: Complete.

Q18CG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAKATAKYV RVSPRKAGQI CDLVRGKNVD EALAILKFTP RGAASIIAKV
60 70 80 90 100
VKSAKANAEN NHEMDTEKLY IASIVANQGP TMKRFMPRAM GRATTIRKRT
110
SHIEVVVKEK K
Length:111
Mass (Da):12,251
Last modified:July 25, 2006 - v1
Checksum:i8B21359B31F0C882
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA Translation: CAJ66893.1
RefSeqiWP_009887891.1, NZ_CP010905.2
YP_001086542.1, NC_009089.1

Genome annotation databases

EnsemblBacteriaiCAJ66893; CAJ66893; CD630_00780
GeneIDi31351568
4915661
KEGGicdf:CD630_00780
pdc:CDIF630_00144
PATRICifig|272563.120.peg.84

Similar proteinsi

Entry informationi

Entry nameiRL22_PEPD6
AccessioniPrimary (citable) accession number: Q18CG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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