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Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-121-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
Gene namesi
Name:rpoBUniRule annotation
Ordered Locus Names:CD630_00660
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2363852.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12381238DNA-directed RNA polymerase subunit betaPRO_0000300300Add
BLAST

Proteomic databases

PRIDEiQ18CF1.

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Protein-protein interaction databases

STRINGi272563.CD0066.

Structurei

3D structure databases

ProteinModelPortaliQ18CF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IIJ. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiEOG6M9DS6.

Family and domain databases

Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 2 hits.
HAMAPiMF_01321. RNApol_bact_RpoB.
InterProiIPR010243. DNA-dir_RNA_pol_bsu.
IPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 2 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18CF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHPVTIGKR TRMSFSKIKE IADVPNLIEI QVDSYEWFLK EGLKEVFDDI
60 70 80 90 100
SPIEDYTGNL ILEFVDYSLD DKPKYDIEEC KERDATYCAP LKVKVRLINK
110 120 130 140 150
ETGEIKEQEV FMGDFPLMTE RGTFVINGAE RVIVSQLVRS PGVYYAEERD
160 170 180 190 200
KTGKRLISST VIPNRGAWLE YETDSNDVIS VRVDRTRKQP VTVLLRALGI
210 220 230 240 250
GTDAEIIDLL GEDERLSATL EKDNTKTVEE GLVEIYKKLR PGEPPTVESA
260 270 280 290 300
SSLLNALFFD PKRYDLAKVG RYKFNKKLAL CYRIMNKISA EDIINPETGE
310 320 330 340 350
VFVKAGEKIS YDLAKAIQNA GINVVNLLMD DDKKVRVIGN NFVDIKSHID
360 370 380 390 400
FDIDDLNIKE KVHYPTLKEI LDGYSDEEEI KEAIKSRIKE LIPKHILLDD
410 420 430 440 450
IIASISYEFN IFYNIGNIDD IDHLGNRRIR SVGELLQNQV RIGLSRMERV
460 470 480 490 500
IKERMTVQDM EAITPQALVN IRPVSAAIKE FFGSSQLSQF MDQTNPLSEL
510 520 530 540 550
THKRRLSALG PGGLSRERAG FEVRDVHHSH YGRMCPIETP EGPNIGLINS
560 570 580 590 600
LGTYAKINEF GFIESPYRKF DKETSTVTDE IHYLTADEED LFVRAQANEP
610 620 630 640 650
LTEDGKFVNH RVVCRTVNGA VEMVPESRVD YMDISPKQVV SVATAMIPFL
660 670 680 690 700
ENDDANRALM GANMQRQAVP LVRREAPIIG TGIEYRAAKD SGAVVVARNS
710 720 730 740 750
GIAERVTADE IIIKREDGNR DRYNLLKFKR SNSGTCINQT PIINKGDQII
760 770 780 790 800
KGDVIADGPA TDLGEVALGR NCLIAFMTWE GYNYEDAILI NERLVKEDRL
810 820 830 840 850
STIHIEEYEC EARDTKLGPE EITRDIPNVG DSAIKNLDDR GIIRIGAEVD
860 870 880 890 900
SGDILVGKVT PKGETELTAE ERLLRAIFGE KAREVRDTSL KVPHGESGII
910 920 930 940 950
VDVKVFTREN GDDLSPGVNE LVRCYIAKKR KIKVGDKMAG RHGNKGVISR
960 970 980 990 1000
VLPEEDMPFM ENGTPLDIIL NPQGIPSRMN IGQVLEVHLG LAAKTLGWYV
1010 1020 1030 1040 1050
ATSVFDGANE YDIMDALEEA GYPRDGKLTL YDGRTGESFD NRITVGYMYY
1060 1070 1080 1090 1100
LKLHHLVDEK LHARSTGPYS LVTQQPLGGK AQFGGQRFGE MEVWALEAYG
1110 1120 1130 1140 1150
AAHILQEILT VKSDDVVGRV RTYEAIVKGE NIPEPGIPES FKVLIKELQS
1160 1170 1180 1190 1200
LCLDVKVLTD EDQEIEVRES VDEDDTIGEF ELDVVNHMGE VEESNIIEEI
1210 1220 1230
EDDFAENAED EDIENLEEFT EDDLFEEEID FDSDDFDM
Length:1,238
Mass (Da):139,323
Last modified:July 25, 2006 - v1
Checksum:iDFB1A1C7CDAE170D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ66881.1.
RefSeqiWP_003436174.1. NC_009089.1.
YP_001086530.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ66881; CAJ66881; CD630_00660.
GeneIDi4914216.
KEGGicdf:CD630_00660.
PATRICi19438271. VBICloDif38397_0077.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ66881.1.
RefSeqiWP_003436174.1. NC_009089.1.
YP_001086530.1. NC_009089.1.

3D structure databases

ProteinModelPortaliQ18CF1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD0066.

Chemistry

ChEMBLiCHEMBL2363852.

Proteomic databases

PRIDEiQ18CF1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ66881; CAJ66881; CD630_00660.
GeneIDi4914216.
KEGGicdf:CD630_00660.
PATRICi19438271. VBICloDif38397_0077.

Phylogenomic databases

eggNOGiENOG4108IIJ. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiEOG6M9DS6.

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-121-MONOMER.

Miscellaneous databases

PROiQ18CF1.

Family and domain databases

Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 2 hits.
HAMAPiMF_01321. RNApol_bact_RpoB.
InterProiIPR010243. DNA-dir_RNA_pol_bsu.
IPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 2 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 630.

Entry informationi

Entry nameiRPOB_PEPD6
AccessioniPrimary (citable) accession number: Q18CF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 25, 2006
Last modified: June 8, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.