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Protein

50S ribosomal protein L1

Gene

rplA

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.UniRule annotation
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor, Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

Translation regulation

Keywords - Ligandi

RNA-binding, rRNA-binding, tRNA-binding

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-116-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L1UniRule annotation
Gene namesi
Name:rplAUniRule annotation
Ordered Locus Names:CD630_00620
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003079921 – 23250S ribosomal protein L1Add BLAST232

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit.UniRule annotation

Protein-protein interaction databases

STRINGi272563.CD0062.

Structurei

3D structure databases

ProteinModelPortaliQ18CE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L1P family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C64. Bacteria.
COG0081. LUCA.
HOGENOMiHOG000207015.
KOiK02863.
OMAiYSDQMIR.

Family and domain databases

CDDicd00403. Ribosomal_L1. 1 hit.
Gene3Di3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
HAMAPiMF_01318_B. Ribosomal_L1_B. 1 hit.
InterProiIPR005878. Ribosom_L1_bac-type.
IPR002143. Ribosomal_L1.
IPR023674. Ribosomal_L1-like.
IPR028364. Ribosomal_L1/biogenesis.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR023673. Ribosomal_L1_CS.
[Graphical view]
PfamiPF00687. Ribosomal_L1. 1 hit.
[Graphical view]
PIRSFiPIRSF002155. Ribosomal_L1. 1 hit.
SUPFAMiSSF56808. SSF56808. 1 hit.
TIGRFAMsiTIGR01169. rplA_bact. 1 hit.
PROSITEiPS01199. RIBOSOMAL_L1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18CE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKGKRYAG ALQKVDRTKF YDASEALTLV SDIAGAKFDE TVEAHIKLGV
60 70 80 90 100
DSRHADQQVR GAVVLPHGTG KTKRVLVFAK GEKAKEAEQA GADFVGAEEL
110 120 130 140 150
VQKIQGENWF DFDIVVATPD MMGVVGRLGR VLGPKGLMPN PKSGTVTFDV
160 170 180 190 200
AKAIDEIKAG KVEYRLDKTN IIHVPVGKVS FGGEKLTENF TALMDAIIKA
210 220 230
KPAAAKGQYL RSITVASSMG PGVKINPART AE
Length:232
Mass (Da):24,807
Last modified:July 25, 2006 - v1
Checksum:iE70108E13DAB99C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ66877.1.
RefSeqiWP_003421188.1. NZ_CP010905.1.
YP_001086526.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ66877; CAJ66877; CD630_00620.
GeneIDi4916675.
KEGGicdf:CD630_00620.
pdc:CDIF630_00127.
PATRICi19438263. VBICloDif38397_0073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ66877.1.
RefSeqiWP_003421188.1. NZ_CP010905.1.
YP_001086526.1. NC_009089.1.

3D structure databases

ProteinModelPortaliQ18CE9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD0062.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ66877; CAJ66877; CD630_00620.
GeneIDi4916675.
KEGGicdf:CD630_00620.
pdc:CDIF630_00127.
PATRICi19438263. VBICloDif38397_0073.

Phylogenomic databases

eggNOGiENOG4105C64. Bacteria.
COG0081. LUCA.
HOGENOMiHOG000207015.
KOiK02863.
OMAiYSDQMIR.

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-116-MONOMER.

Family and domain databases

CDDicd00403. Ribosomal_L1. 1 hit.
Gene3Di3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
HAMAPiMF_01318_B. Ribosomal_L1_B. 1 hit.
InterProiIPR005878. Ribosom_L1_bac-type.
IPR002143. Ribosomal_L1.
IPR023674. Ribosomal_L1-like.
IPR028364. Ribosomal_L1/biogenesis.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR023673. Ribosomal_L1_CS.
[Graphical view]
PfamiPF00687. Ribosomal_L1. 1 hit.
[Graphical view]
PIRSFiPIRSF002155. Ribosomal_L1. 1 hit.
SUPFAMiSSF56808. SSF56808. 1 hit.
TIGRFAMsiTIGR01169. rplA_bact. 1 hit.
PROSITEiPS01199. RIBOSOMAL_L1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL1_PEPD6
AccessioniPrimary (citable) accession number: Q18CE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 25, 2006
Last modified: November 2, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.