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Q18CE4

- EFTU_PEPD6

UniProt

Q18CE4 - EFTU_PEPD6

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Protein
Elongation factor Tu
Gene
tuf1, tufA, CD630_00580
tuf1, tufB, CD630_00710
Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTP By similarity
Nucleotide bindingi82 – 865GTP By similarity
Nucleotide bindingi137 – 1404GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. GTPase activity Source: InterPro
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-112-MONOMER.
CDIF272563:GJFE-126-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor Tu
Short name:
EF-Tu
Gene namesi
Name:tuf1
Synonyms:tufA
Ordered Locus Names:CD630_00580
AND
Name:tuf1
Synonyms:tufB
Ordered Locus Names:CD630_00710
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
ProteomesiUP000001978: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Elongation factor TuUniRule annotation
PRO_0000337361Add
BLAST

Proteomic databases

PRIDEiQ18CE4.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272563.CD0071.

Structurei

3D structure databases

ProteinModelPortaliQ18CE4.
SMRiQ18CE4. Positions 2-397.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 206197tr-type G
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 268G1 By similarity
Regioni61 – 655G2 By similarity
Regioni82 – 854G3 By similarity
Regioni137 – 1404G4 By similarity
Regioni175 – 1773G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OMAiGTEMCMP.
OrthoDBiEOG6R5C6X.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18CE4-1 [UniParc]FASTAAdd to Basket

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MAKAKYERTK PHVNIGTIGH VDHGKTTLTA AITKTLYDRY QLGEAVDFAN    50
IDKAPEERER GITISTAHVE YETPNRHYAH VDCPGHADYV KNMITGAAQM 100
DGAILVCSAT DGPMPQTREH ILLSRQVGVP YIVVFLNKCD MVDDEELLEL 150
VEMEVRDLLT EYDFPGDDTP IVRGSALMAL EDPKSEWGDK IVELFEQIDE 200
YIPAPERDTD KPFLMPVEDV FSITGRGTVA TGRVERGVLK VQDEVELVGL 250
TEAPRKVVVT GVEMFRKLLD QAQAGDNIGA LLRGVQRNEI ERGQVLAKTG 300
SVKAHTKFTA EVYVLKKEEG GRHTPFFDGY RPQFYFRTTD VTGACKLPEG 350
IEMVMPGDNV TMEVDLINSI VVEEGLRFSI REGGRTVASG VVATIIE 397
Length:397
Mass (Da):44,026
Last modified:July 25, 2006 - v1
Checksum:iD2B6360068769C99
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180355 Genomic DNA. Translation: CAJ66872.1.
AM180355 Genomic DNA. Translation: CAJ66886.1.
RefSeqiYP_001086521.1. NC_009089.1.
YP_001086535.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ66872; CAJ66872; CD630_00580.
CAJ66886; CAJ66886; CD630_00710.
GeneIDi4914221.
4916670.
KEGGicdf:CD630_00580.
cdf:CD630_00710.
PATRICi19438253. VBICloDif38397_0068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180355 Genomic DNA. Translation: CAJ66872.1 .
AM180355 Genomic DNA. Translation: CAJ66886.1 .
RefSeqi YP_001086521.1. NC_009089.1.
YP_001086535.1. NC_009089.1.

3D structure databases

ProteinModelPortali Q18CE4.
SMRi Q18CE4. Positions 2-397.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272563.CD0071.

Proteomic databases

PRIDEi Q18CE4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ66872 ; CAJ66872 ; CD630_00580 .
CAJ66886 ; CAJ66886 ; CD630_00710 .
GeneIDi 4914221.
4916670.
KEGGi cdf:CD630_00580.
cdf:CD630_00710.
PATRICi 19438253. VBICloDif38397_0068.

Phylogenomic databases

eggNOGi COG0050.
HOGENOMi HOG000229290.
KOi K02358.
OMAi GTEMCMP.
OrthoDBi EOG6R5C6X.

Enzyme and pathway databases

BioCyci CDIF272563:GJFE-112-MONOMER.
CDIF272563:GJFE-126-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00118_B. EF_Tu_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view ]
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 630.

Entry informationi

Entry nameiEFTU_PEPD6
AccessioniPrimary (citable) accession number: Q18CE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 25, 2006
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi