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Q18CE4 (EFTU_CLOD6) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Elongation factor Tu

Short name=EF-Tu
Gene names
Name:tuf1
Synonyms:tufA
Ordered Locus Names:CD630_00580
AND
Name:tuf1
Synonyms:tufB
Ordered Locus Names:CD630_00710
OrganismClostridium difficile (strain 630) [Complete proteome] [HAMAP]
Taxonomic identifier272563 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceae

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity. HAMAP-Rule MF_00118

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00118

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00118.

Sequence similarities

Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionElongation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

GTPase activity

Inferred from electronic annotation. Source: InterPro

translation elongation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 397397Elongation factor Tu HAMAP-Rule MF_00118
PRO_0000337361

Regions

Nucleotide binding19 – 268GTP By similarity
Nucleotide binding82 – 865GTP By similarity
Nucleotide binding137 – 1404GTP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q18CE4 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: D2B6360068769C99

FASTA39744,026
        10         20         30         40         50         60 
MAKAKYERTK PHVNIGTIGH VDHGKTTLTA AITKTLYDRY QLGEAVDFAN IDKAPEERER 

        70         80         90        100        110        120 
GITISTAHVE YETPNRHYAH VDCPGHADYV KNMITGAAQM DGAILVCSAT DGPMPQTREH 

       130        140        150        160        170        180 
ILLSRQVGVP YIVVFLNKCD MVDDEELLEL VEMEVRDLLT EYDFPGDDTP IVRGSALMAL 

       190        200        210        220        230        240 
EDPKSEWGDK IVELFEQIDE YIPAPERDTD KPFLMPVEDV FSITGRGTVA TGRVERGVLK 

       250        260        270        280        290        300 
VQDEVELVGL TEAPRKVVVT GVEMFRKLLD QAQAGDNIGA LLRGVQRNEI ERGQVLAKTG 

       310        320        330        340        350        360 
SVKAHTKFTA EVYVLKKEEG GRHTPFFDGY RPQFYFRTTD VTGACKLPEG IEMVMPGDNV 

       370        380        390 
TMEVDLINSI VVEEGLRFSI REGGRTVASG VVATIIE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM180355 Genomic DNA. Translation: CAJ66872.1.
AM180355 Genomic DNA. Translation: CAJ66886.1.
RefSeqYP_001086521.1. NC_009089.1.
YP_001086535.1. NC_009089.1.

3D structure databases

ProteinModelPortalQ18CE4.
SMRQ18CE4. Positions 2-397.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272563.CD0071.

Proteomic databases

PRIDEQ18CE4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ66872; CAJ66872; CD630_00580.
CAJ66886; CAJ66886; CD630_00710.
GeneID4914221.
4916670.
KEGGcdf:CD630_00580.
cdf:CD630_00710.
PATRIC19438253. VBICloDif38397_0068.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0050.
HOGENOMHOG000229290.
KOK02358.
OMAVTPHTEF.
OrthoDBEOG6R5C6X.
ProtClustDBPRK12735.

Enzyme and pathway databases

BioCycCDIF272563:GJFE-112-MONOMER.
CDIF272563:GJFE-126-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00118_B. EF_Tu_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SUPFAMSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEFTU_CLOD6
AccessionPrimary (citable) accession number: Q18CE4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 25, 2006
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families