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Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.UniRule annotation

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC), Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-1721-MONOMER.
UniPathwayiUPA00031; UER00006.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferaseUniRule annotation (EC:2.4.2.17UniRule annotation)
Short name:
ATP-PRTUniRule annotation
Short name:
ATP-PRTaseUniRule annotation
Gene namesi
Name:hisGUniRule annotation
Ordered Locus Names:CD630_15480
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208ATP phosphoribosyltransferasePRO_0000319517Add
BLAST

Proteomic databases

PRIDEiQ18C67.

Interactioni

Subunit structurei

Heteromultimer composed of HisG and HisZ subunits.UniRule annotation

Protein-protein interaction databases

STRINGi272563.CD1548.

Structurei

3D structure databases

ProteinModelPortaliQ18C67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Lacks the C-terminal regulatory region which is replaced by HisZ.

Sequence similaritiesi

Belongs to the ATP phosphoribosyltransferase family. Short subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E21. Bacteria.
COG0040. LUCA.
HOGENOMiHOG000223248.
KOiK00765.
OMAiVATKFPR.
OrthoDBiEOG66MQT3.

Family and domain databases

HAMAPiMF_01018. HisG_Short.
InterProiIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR024893. ATP_PRibTrfase_HisG_short.
[Graphical view]
PANTHERiPTHR21403. PTHR21403. 1 hit.
PfamiPF01634. HisG. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00070. hisG. 1 hit.
PROSITEiPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18C67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYLTIALAK GRIEGESFKK FKKMGLGDSI DTDTRKLIFK DEENKIIYIH
60 70 80 90 100
VKPSDVVTYV EKGVADLGIA GKDTILENET DVYEIYDLGF GKCKFAVAGL
110 120 130 140 150
KGDSIYREDE YLKVATKYPN IAKKYFKEKG QKIEIIKLNG SVELAPIVGL
160 170 180 190 200
SDVIVDIVET GNTLKANGLE ILEDICNISA RIISNRASYR FKYEQIQNII

RLFEELDN
Length:208
Mass (Da):23,491
Last modified:July 25, 2006 - v1
Checksum:i4413645B24C96129
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ68413.1.
RefSeqiWP_003436683.1. NZ_CP010905.1.
YP_001088049.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ68413; CAJ68413; CD630_15480.
GeneIDi4916284.
KEGGicdf:CD630_15480.
pdc:CDIF630_01717.
PATRICi19441473. VBICloDif38397_1624.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ68413.1.
RefSeqiWP_003436683.1. NZ_CP010905.1.
YP_001088049.1. NC_009089.1.

3D structure databases

ProteinModelPortaliQ18C67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD1548.

Proteomic databases

PRIDEiQ18C67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ68413; CAJ68413; CD630_15480.
GeneIDi4916284.
KEGGicdf:CD630_15480.
pdc:CDIF630_01717.
PATRICi19441473. VBICloDif38397_1624.

Phylogenomic databases

eggNOGiENOG4105E21. Bacteria.
COG0040. LUCA.
HOGENOMiHOG000223248.
KOiK00765.
OMAiVATKFPR.
OrthoDBiEOG66MQT3.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00006.
BioCyciCDIF272563:GJFE-1721-MONOMER.

Family and domain databases

HAMAPiMF_01018. HisG_Short.
InterProiIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR024893. ATP_PRibTrfase_HisG_short.
[Graphical view]
PANTHERiPTHR21403. PTHR21403. 1 hit.
PfamiPF01634. HisG. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00070. hisG. 1 hit.
PROSITEiPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 630.

Entry informationi

Entry nameiHIS1_PEPD6
AccessioniPrimary (citable) accession number: Q18C67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 25, 2006
Last modified: November 11, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.