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Q18C33

- PANC_PEPD6

UniProt

Q18C33 - PANC_PEPD6

Protein

Pantothenate synthetase

Gene

panC

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei36 – 361Proton donorUniRule annotation
    Binding sitei60 – 601Beta-alanineUniRule annotation
    Binding sitei60 – 601PantoateUniRule annotation
    Binding sitei152 – 1521PantoateUniRule annotation
    Binding sitei175 – 1751ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi29 – 368ATPUniRule annotation
    Nucleotide bindingi146 – 1494ATPUniRule annotation
    Nucleotide bindingi183 – 1864ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCDIF272563:GJFE-1684-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Gene namesi
    Name:panCUniRule annotation
    Ordered Locus Names:CD630_15120
    OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
    Taxonomic identifieri272563 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
    ProteomesiUP000001978: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 282282Pantothenate synthetasePRO_0000305426Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272563.CD1512.

    Structurei

    3D structure databases

    ProteinModelPortaliQ18C33.
    SMRiQ18C33. Positions 3-277.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    HOGENOMiHOG000175517.
    KOiK01918.
    OMAiIHTIREL.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q18C33-1 [UniParc]FASTAAdd to Basket

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    MLVKEIKLLR NIIKDWRKHG YSIGLVTTMG FLHEGHQSLI KKAVKENDKV    50
    VVSVFVNPTQ FGPNEDFNSY PRDIDKDFKY CMDSGATVVF NPSPEEMYLK 100
    GNCTTINVSG LTDFLCGAKR PVHFGGVCLV VSKFLNIVTP DKAYFGEKDA 150
    QQLAVIKRMV KDLNIDTEII GCPIIRENDG LAKSSRNTYL SEEERKSALI 200
    LNKSLSLAKE ELVKGNLNPE NIKELITAKI NSEHLAKIDY VEIVDSETLQ 250
    PVKQIEHSIL VAIAVFIGKT RLIDNFTFEL NI 282
    Length:282
    Mass (Da):31,691
    Last modified:July 25, 2006 - v1
    Checksum:iE18317B71E2DBF8C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180355 Genomic DNA. Translation: CAJ68377.1.
    RefSeqiYP_001088013.1. NC_009089.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ68377; CAJ68377; CD630_15120.
    GeneIDi4916551.
    KEGGicdf:CD630_15120.
    PATRICi19441397. VBICloDif38397_1586.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180355 Genomic DNA. Translation: CAJ68377.1 .
    RefSeqi YP_001088013.1. NC_009089.1.

    3D structure databases

    ProteinModelPortali Q18C33.
    SMRi Q18C33. Positions 3-277.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272563.CD1512.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ68377 ; CAJ68377 ; CD630_15120 .
    GeneIDi 4916551.
    KEGGi cdf:CD630_15120.
    PATRICi 19441397. VBICloDif38397_1586.

    Phylogenomic databases

    eggNOGi COG0414.
    HOGENOMi HOG000175517.
    KOi K01918.
    OMAi IHTIREL.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci CDIF272563:GJFE-1684-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 630.

    Entry informationi

    Entry nameiPANC_PEPD6
    AccessioniPrimary (citable) accession number: Q18C33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3