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Q18BW7 (GCH1_PEPD6) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:CD630_14490
OrganismPeptoclostridium difficile (strain 630) (Clostridium difficile) [Complete proteome] [HAMAP]
Taxonomic identifier272563 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium

Protein attributes

Sequence length190 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 190190GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_1000043681

Sites

Metal binding791Zinc By similarity
Metal binding821Zinc By similarity
Metal binding1511Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q18BW7 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 6879BA067D5ABAC3

FASTA19021,468
        10         20         30         40         50         60 
MNKVDKEKIQ HAVREILEAI GEDPDREGLI ETPNRVARMY EEIFSGLSEE PRDHLKVLFA 

        70         80         90        100        110        120 
DEKHEELVLV KDIPFYSCCE HHLVPFFGKA HIAYLPKGGR LTGLSKLARV IDTLAKRPQL 

       130        140        150        160        170        180 
QERITKNAAD IIMEELQPYG VLVVVEAEHM CMTMRGVKKP GSKTVTSAVR GIFEKDIASR 

       190 
AEAMSLITMK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM180355 Genomic DNA. Translation: CAJ68314.1.
RefSeqYP_001087950.1. NC_009089.1.

3D structure databases

ProteinModelPortalQ18BW7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272563.CD1449.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ68314; CAJ68314; CD630_14490.
GeneID4915721.
KEGGcdf:CD630_14490.
PATRIC19441267. VBICloDif38397_1521.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMAQRIAEHM.
OrthoDBEOG6XHC8G.

Enzyme and pathway databases

BioCycCDIF272563:GJFE-1620-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_PEPD6
AccessionPrimary (citable) accession number: Q18BW7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways