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Q18BJ5

- UPPP1_PEPD6

UniProt

Q18BJ5 - UPPP1_PEPD6

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Protein

Undecaprenyl-diphosphatase 1

Gene

uppP1

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-1496-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 1UniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance protein 1UniRule annotation
Undecaprenyl pyrophosphate phosphatase 1UniRule annotation
Gene namesi
Name:uppP1UniRule annotation
Synonyms:bacA1, upk1
Ordered Locus Names:CD630_13320
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
ProteomesiUP000001978: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Undecaprenyl-diphosphatase 1PRO_0000290698Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272563.CD1332.

Structurei

3D structure databases

ProteinModelPortaliQ18BJ5.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalUniRule annotationAdd
BLAST
Transmembranei48 – 6821HelicalUniRule annotationAdd
BLAST
Transmembranei88 – 10821HelicalUniRule annotationAdd
BLAST
Transmembranei115 – 13521HelicalUniRule annotationAdd
BLAST
Transmembranei151 – 17121HelicalUniRule annotationAdd
BLAST
Transmembranei189 – 20921HelicalUniRule annotationAdd
BLAST
Transmembranei221 – 24121HelicalUniRule annotationAdd
BLAST
Transmembranei253 – 27321HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18BJ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METFSLLEIF KAVILGIVQG ITEWLPVSST GHMILVDEFI KLNFSNTFIS
60 70 80 90 100
TFLVVIQFGS ILAVLVIFFR KLNPFDSAKN IKQKKETVRL WLKVIIAVIP
110 120 130 140 150
SGVIGILFED DIDRLFFNST VVAIALIVYG IIMIGLEKRN KRPKYKDFSQ
160 170 180 190 200
VTYKLALCIG LFQCLALIPG TSRSGSTIIG AVLLGTSRYV AAEFSFFLAI
210 220 230 240 250
PTMLGASALK LLKAGFGFTG FEWLILGVGS VVAFVVSIVV IKFFMDYIKK
260 270
HDFKVFGYYR IVLGIVVLAY FFLL
Length:274
Mass (Da):30,560
Last modified:July 25, 2006 - v1
Checksum:i7724B00549DC8F98
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180355 Genomic DNA. Translation: CAJ68190.1.
RefSeqiYP_001087828.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ68190; CAJ68190; CD630_13320.
GeneIDi4914619.
KEGGicdf:CD630_13320.
PATRICi19441023. VBICloDif38397_1399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180355 Genomic DNA. Translation: CAJ68190.1 .
RefSeqi YP_001087828.1. NC_009089.1.

3D structure databases

ProteinModelPortali Q18BJ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272563.CD1332.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ68190 ; CAJ68190 ; CD630_13320 .
GeneIDi 4914619.
KEGGi cdf:CD630_13320.
PATRICi 19441023. VBICloDif38397_1399.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci CDIF272563:GJFE-1496-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 630.

Entry informationi

Entry nameiUPPP1_PEPD6
AccessioniPrimary (citable) accession number: Q18BJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: July 25, 2006
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3