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Q18BJ5 (UPPP1_CLOD6) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase 1

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein 1
Undecaprenyl pyrophosphate phosphatase 1
Gene names
Name:uppP1
Synonyms:bacA1, upk1
Ordered Locus Names:CD630_13320
OrganismClostridium difficile (strain 630) [Complete proteome] [HAMAP]
Taxonomic identifier272563 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceae

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Undecaprenyl-diphosphatase 1 HAMAP-Rule MF_01006
PRO_0000290698

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane48 – 6821Helical; Potential
Transmembrane88 – 10821Helical; Potential
Transmembrane115 – 13521Helical; Potential
Transmembrane151 – 17121Helical; Potential
Transmembrane189 – 20921Helical; Potential
Transmembrane221 – 24121Helical; Potential
Transmembrane253 – 27321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q18BJ5 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 7724B00549DC8F98

FASTA27430,560
        10         20         30         40         50         60 
METFSLLEIF KAVILGIVQG ITEWLPVSST GHMILVDEFI KLNFSNTFIS TFLVVIQFGS 

        70         80         90        100        110        120 
ILAVLVIFFR KLNPFDSAKN IKQKKETVRL WLKVIIAVIP SGVIGILFED DIDRLFFNST 

       130        140        150        160        170        180 
VVAIALIVYG IIMIGLEKRN KRPKYKDFSQ VTYKLALCIG LFQCLALIPG TSRSGSTIIG 

       190        200        210        220        230        240 
AVLLGTSRYV AAEFSFFLAI PTMLGASALK LLKAGFGFTG FEWLILGVGS VVAFVVSIVV 

       250        260        270 
IKFFMDYIKK HDFKVFGYYR IVLGIVVLAY FFLL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM180355 Genomic DNA. Translation: CAJ68190.1.
RefSeqYP_001087828.1. NC_009089.1.

3D structure databases

ProteinModelPortalQ18BJ5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272563.CD1332.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ68190; CAJ68190; CD630_13320.
GeneID4914619.
KEGGcdf:CD630_13320.
PATRIC19441023. VBICloDif38397_1399.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAIFAWLRI.
OrthoDBEOG6QP13M.
ProtClustDBCLSK2534818.

Enzyme and pathway databases

BioCycCDIF272563:GJFE-1496-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP1_CLOD6
AccessionPrimary (citable) accession number: Q18BJ5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: July 25, 2006
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families