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Protein

tRNA pseudouridine synthase B

Gene

truB

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(55) = tRNA pseudouridine(55).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381NucleophileUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-1477-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase BUniRule annotation (EC:5.4.99.25UniRule annotation)
Alternative name(s):
tRNA pseudouridine(55) synthaseUniRule annotation
Short name:
Psi55 synthaseUniRule annotation
tRNA pseudouridylate synthaseUniRule annotation
tRNA-uridine isomeraseUniRule annotation
Gene namesi
Name:truBUniRule annotation
Ordered Locus Names:CD630_13140
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
Proteomesi
  • UP000001978 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301tRNA pseudouridine synthase BPRO_1000084571Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272563.CD1314.

Structurei

3D structure databases

ProteinModelPortaliQ18BH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D0T. Bacteria.
COG0130. LUCA.
HOGENOMiHOG000231225.
KOiK03177.
OMAiDYSFLIP.

Family and domain databases

HAMAPiMF_01080. TruB_bact. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR002501. PsdUridine_synth_N.
IPR014780. tRNA_psdUridine_synth_TruB.
IPR032819. TruB_C.
[Graphical view]
PANTHERiPTHR13767. PTHR13767. 1 hit.
PfamiPF16198. TruB_C_2. 1 hit.
PF01509. TruB_N. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00431. TruB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18BH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKIISILKP TGMTSHDVVS RVRKILNIKK VGHTGTLDPD ASGVLPICIG
60 70 80 90 100
KATKVCEVIL NKDKSYICEL TLGISTDTYD ASGEILKKVD DFKFSNEDIE
110 120 130 140 150
RAFDTQRGEI NQLPPIYSAL KVNGKRMCDL VRSGRQSEIT LKTRRVNIKD
160 170 180 190 200
IKILSIKGNK VMFYVECSKG TYVRSICHDI GEYLGCGAHM SFLNRTSSGK
210 220 230 240 250
FDLDNSITLE ELELFYENKT LDKYLYDIDY VLDSFNYVVL NPNAIKYYSN
260 270 280 290 300
GGSIDDKRFL KNNFDKDDEF VRVYSTDNFL GLGKLSKHNN TISVKSDKMF

I
Length:301
Mass (Da):34,091
Last modified:July 25, 2006 - v1
Checksum:i7C66655C842CD599
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ68171.1.
RefSeqiWP_003428232.1. NZ_CP010905.1.
YP_001087809.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ68171; CAJ68171; CD630_13140.
GeneIDi4914473.
KEGGicdf:CD630_13140.
pdc:CDIF630_01470.
PATRICi19440987. VBICloDif38397_1381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ68171.1.
RefSeqiWP_003428232.1. NZ_CP010905.1.
YP_001087809.1. NC_009089.1.

3D structure databases

ProteinModelPortaliQ18BH7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD1314.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ68171; CAJ68171; CD630_13140.
GeneIDi4914473.
KEGGicdf:CD630_13140.
pdc:CDIF630_01470.
PATRICi19440987. VBICloDif38397_1381.

Phylogenomic databases

eggNOGiENOG4105D0T. Bacteria.
COG0130. LUCA.
HOGENOMiHOG000231225.
KOiK03177.
OMAiDYSFLIP.

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-1477-MONOMER.

Family and domain databases

HAMAPiMF_01080. TruB_bact. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR002501. PsdUridine_synth_N.
IPR014780. tRNA_psdUridine_synth_TruB.
IPR032819. TruB_C.
[Graphical view]
PANTHERiPTHR13767. PTHR13767. 1 hit.
PfamiPF16198. TruB_C_2. 1 hit.
PF01509. TruB_N. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00431. TruB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRUB_PEPD6
AccessioniPrimary (citable) accession number: Q18BH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 25, 2006
Last modified: September 7, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.