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Protein

Phosphopentomutase

Gene

deoB

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Phosphotransfer between the C1 and C5 carbon atoms of pentose.UniRule annotation

Catalytic activityi

Alpha-D-ribose 1-phosphate = D-ribose 5-phosphate.UniRule annotation
2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-alpha-D-ribose 5-phosphate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 or 2 manganese ions.UniRule annotation

Pathwayi: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Phosphopentomutase (deoB)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II), the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi10ManganeseUniRule annotation1
Metal bindingi289ManganeseUniRule annotation1
Metal bindingi325ManganeseUniRule annotation1
Metal bindingi326ManganeseUniRule annotation1
Metal bindingi337ManganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-1354-MONOMER.
UniPathwayiUPA00087; UER00173.

Names & Taxonomyi

Protein namesi
Recommended name:
PhosphopentomutaseUniRule annotation (EC:5.4.2.7UniRule annotation)
Alternative name(s):
PhosphodeoxyribomutaseUniRule annotation
Gene namesi
Name:deoBUniRule annotation
Ordered Locus Names:CD630_12230
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002582781 – 390PhosphopentomutaseAdd BLAST390

Proteomic databases

PRIDEiQ18B86.

Interactioni

Protein-protein interaction databases

STRINGi272563.CD1223.

Structurei

3D structure databases

ProteinModelPortaliQ18B86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphopentomutase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZG. Bacteria.
COG1015. LUCA.
HOGENOMiHOG000008159.
KOiK01839.
OMAiYLGNCHA.

Family and domain databases

Gene3Di3.30.70.1250. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_00740. Phosphopentomut. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR010045. DeoB.
IPR006124. Metalloenzyme.
IPR024052. Phosphopentomutase_DeoB_cap.
[Graphical view]
PfamiPF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001491. Ppentomutase. 1 hit.
SUPFAMiSSF143856. SSF143856. 1 hit.
SSF53649. SSF53649. 2 hits.
TIGRFAMsiTIGR01696. deoB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18B86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRVIWIVID SVGIGALPDA EKFGDSKDVS TLGNIFKEYP DIQIPNMRNL
60 70 80 90 100
GIGNIDGIDF FESIKEPIGC FGKCKEMSQG KDTTTGHWEM TGIIVDKPFK
110 120 130 140 150
TFEHGFSKEI IEEFEKKTGR KVVGNKPASG TVIIDEYGEH QIKTGDVIVY
160 170 180 190 200
TSADSVFQIA ANEEVIPLEE LYNMCKIARE IMMGDNAVAR VIARPFIGKK
210 220 230 240 250
KGEFVRTSNR RDYSLDPFEP TVLDNIKESG LDVLAVGKIE DIFNGKGITD
260 270 280 290 300
AIHTKSNMDG VDETLNYMKQ DNKGLIYSNL VDFDSKYGHR RDPEGYKKAL
310 320 330 340 350
EEFDSRLPEI MANMREDDIL IINADHGNDP TYKGTDHTRE YIPVMIYGNK
360 370 380 390
IKKGFNLGVK DTFADIGATV ADILNVKLPK HGSSFKGDLF
Length:390
Mass (Da):43,576
Last modified:July 25, 2006 - v1
Checksum:iB6933A5E5643AC35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ68077.1.
RefSeqiWP_011861145.1. NZ_CP010905.1.
YP_001087716.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ68077; CAJ68077; CD630_12230.
GeneIDi4914865.
KEGGicdf:CD630_12230.
pdc:CDIF630_01372.
PATRICi19440789. VBICloDif38397_1282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ68077.1.
RefSeqiWP_011861145.1. NZ_CP010905.1.
YP_001087716.1. NC_009089.1.

3D structure databases

ProteinModelPortaliQ18B86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD1223.

Proteomic databases

PRIDEiQ18B86.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ68077; CAJ68077; CD630_12230.
GeneIDi4914865.
KEGGicdf:CD630_12230.
pdc:CDIF630_01372.
PATRICi19440789. VBICloDif38397_1282.

Phylogenomic databases

eggNOGiENOG4105CZG. Bacteria.
COG1015. LUCA.
HOGENOMiHOG000008159.
KOiK01839.
OMAiYLGNCHA.

Enzyme and pathway databases

UniPathwayiUPA00087; UER00173.
BioCyciPDIF272563:G12WB-1354-MONOMER.

Family and domain databases

Gene3Di3.30.70.1250. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_00740. Phosphopentomut. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR010045. DeoB.
IPR006124. Metalloenzyme.
IPR024052. Phosphopentomutase_DeoB_cap.
[Graphical view]
PfamiPF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001491. Ppentomutase. 1 hit.
SUPFAMiSSF143856. SSF143856. 1 hit.
SSF53649. SSF53649. 2 hits.
TIGRFAMsiTIGR01696. deoB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDEOB_PEPD6
AccessioniPrimary (citable) accession number: Q18B86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 25, 2006
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.