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Protein

Purine nucleoside phosphorylase

Gene

pupG

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.UniRule annotation

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: purine nucleoside salvage

This protein is involved in the pathway purine nucleoside salvage, which is part of Purine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway purine nucleoside salvage and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotationImported, Transferase

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-1389-MONOMER.
UniPathwayiUPA00606.

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylaseUniRule annotation (EC:2.4.2.1UniRule annotation)
Alternative name(s):
Inosine-guanosine phosphorylaseUniRule annotation
Gene namesi
Name:pupGImported
Ordered Locus Names:CD630_12240Imported
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)Imported
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
Proteomesi
  • UP000001978 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi272563.CD1224.

Structurei

3D structure databases

ProteinModelPortaliQ18B85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 267247PNP_UDP_1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CB1. Bacteria.
COG0005. LUCA.
HOGENOMiHOG000045183.
KOiK03783.
OMAiVGRIHAY.
OrthoDBiEOG6423M2.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
InterProiIPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR011270. Pur_Nuc_Pase_Ino/Guo-sp.
IPR011268. Purine_phosphorylase.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PTHR11904:SF9. PTHR11904:SF9. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000477. PurNPase. 1 hit.
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01700. PNPH. 1 hit.
TIGR01697. PNPH-PUNA-XAPA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18B85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEKIAQSSK FINSKSNIKP KIGLILGSGL GDLANDIEDP VTIKYSEIPN
60 70 80 90 100
FPVSTVAGHA GQLVIGKLEG KEVIAMQGRF HYYEGYSQKE ATFPVRVMKE
110 120 130 140 150
LGVEILIVTN AAGGVNKEFK AGDLMLIRDH INFSGSNPLV GKNDDRFGAR
160 170 180 190 200
FPDMSDAYSS KYVDVVKNCA KECNIDVKEG VYMFFSGPNY ETSAEVRMAQ
210 220 230 240 250
ILGADAVGMS TVPEVIVASH SNIGVIGISC ITNMAAGILN QPLSHEEVIE
260 270
TTQKVKSEFM NLVKTTVKNL
Length:270
Mass (Da):29,319
Last modified:July 25, 2006 - v1
Checksum:i8752BFC368D5E1D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ68078.1.
RefSeqiWP_011861146.1. NZ_CP010905.1.
YP_001087717.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ68078; CAJ68078; CD630_12240.
GeneIDi4914866.
KEGGicdf:CD630_12240.
pdc:CDIF630_01373.
PATRICi19440791. VBICloDif38397_1283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ68078.1.
RefSeqiWP_011861146.1. NZ_CP010905.1.
YP_001087717.1. NC_009089.1.

3D structure databases

ProteinModelPortaliQ18B85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD1224.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ68078; CAJ68078; CD630_12240.
GeneIDi4914866.
KEGGicdf:CD630_12240.
pdc:CDIF630_01373.
PATRICi19440791. VBICloDif38397_1283.

Phylogenomic databases

eggNOGiENOG4105CB1. Bacteria.
COG0005. LUCA.
HOGENOMiHOG000045183.
KOiK03783.
OMAiVGRIHAY.
OrthoDBiEOG6423M2.

Enzyme and pathway databases

UniPathwayiUPA00606.
BioCyciCDIF272563:GJFE-1389-MONOMER.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
InterProiIPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR011270. Pur_Nuc_Pase_Ino/Guo-sp.
IPR011268. Purine_phosphorylase.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PTHR11904:SF9. PTHR11904:SF9. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000477. PurNPase. 1 hit.
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01700. PNPH. 1 hit.
TIGR01697. PNPH-PUNA-XAPA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 630Imported.

Entry informationi

Entry nameiQ18B85_PEPD6
AccessioniPrimary (citable) accession number: Q18B85
Entry historyi
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: May 11, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.