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Protein

Phosphate acyltransferase

Gene

plsX

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible formation of acyl-phosphate (acyl-PO4) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.UniRule annotation

Catalytic activityi

Acyl-[acyl-carrier-protein] + phosphate = acyl-phosphate + [acyl-carrier-protein].UniRule annotation

Pathwayi: phospholipid metabolism

This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-1343-MONOMER.
UniPathwayiUPA00085.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acyltransferaseUniRule annotation (EC:2.3.1.n2UniRule annotation)
Alternative name(s):
Acyl-ACP phosphotransacylaseUniRule annotation
Acyl-[acyl-carrier-protein]--phosphate acyltransferaseUniRule annotation
Phosphate-acyl-ACP acyltransferaseUniRule annotation
Gene namesi
Name:plsXUniRule annotation
Ordered Locus Names:CD630_11780
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

  • Note: Associated with the membrane possibly through PlsY.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Phosphate acyltransferasePRO_1000001748Add
BLAST

Interactioni

Subunit structurei

Homodimer. Probably interacts with PlsY.UniRule annotation

Protein-protein interaction databases

STRINGi272563.CD1178.

Structurei

3D structure databases

ProteinModelPortaliQ18B41.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PlsX family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6B. Bacteria.
COG0416. LUCA.
HOGENOMiHOG000154731.
KOiK03621.
OMAiKFCLRTM.
OrthoDBiEOG68H88P.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00019. PlsX.
InterProiIPR003664. FA_synthesis.
IPR024084. IsoPropMal-DH-like_dom.
IPR012281. Phospholipid_synth_PlsX-like.
[Graphical view]
PfamiPF02504. FA_synthesis. 1 hit.
[Graphical view]
PIRSFiPIRSF002465. Phsphlp_syn_PlsX. 1 hit.
TIGRFAMsiTIGR00182. plsX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18B41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIVIDGMGG DNAPKSNVEG AVNAIKEYQV DLIITGDKDL LEKEFSNYEF
60 70 80 90 100
DRNKLEIVHT TEIIENEDKP VKAIRSKKDS SMVVALNLVK EGKADAIISA
110 120 130 140 150
GNTGALLAGG LFVVGRIKGI DRPCLCSAIP NVKRGMTLIA DCGANADCKP
160 170 180 190 200
KNLVEFAAMS NIYSRKVLGL ENPKVALANV GLEEGKGNDL VKRSYEEIKK
210 220 230 240 250
LDLNFIGNVE AREVINAYTD IIICDGFTGN ILLKSAEGVA LSVMSLIKET
260 270 280 290 300
FMASTKSKIG ALLIKDDLRK LKSFIDYSEY GGAPLLGLNG GVIKAHGSSD
310 320 330 340
AKAIKNAINQ GIKFSKGKVV EDINQFISKY NEENKNNEDE
Length:340
Mass (Da):36,762
Last modified:July 25, 2006 - v1
Checksum:i7A235944B4901AC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ68032.1.
RefSeqiWP_003428446.1. NZ_CP010905.1.
YP_001087671.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ68032; CAJ68032; CD630_11780.
GeneIDi4916381.
KEGGicdf:CD630_11780.
pdc:CDIF630_01327.
PATRICi19440699. VBICloDif38397_1237.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ68032.1.
RefSeqiWP_003428446.1. NZ_CP010905.1.
YP_001087671.1. NC_009089.1.

3D structure databases

ProteinModelPortaliQ18B41.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD1178.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ68032; CAJ68032; CD630_11780.
GeneIDi4916381.
KEGGicdf:CD630_11780.
pdc:CDIF630_01327.
PATRICi19440699. VBICloDif38397_1237.

Phylogenomic databases

eggNOGiENOG4105C6B. Bacteria.
COG0416. LUCA.
HOGENOMiHOG000154731.
KOiK03621.
OMAiKFCLRTM.
OrthoDBiEOG68H88P.

Enzyme and pathway databases

UniPathwayiUPA00085.
BioCyciCDIF272563:GJFE-1343-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00019. PlsX.
InterProiIPR003664. FA_synthesis.
IPR024084. IsoPropMal-DH-like_dom.
IPR012281. Phospholipid_synth_PlsX-like.
[Graphical view]
PfamiPF02504. FA_synthesis. 1 hit.
[Graphical view]
PIRSFiPIRSF002465. Phsphlp_syn_PlsX. 1 hit.
TIGRFAMsiTIGR00182. plsX. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 630.

Entry informationi

Entry nameiPLSX_PEPD6
AccessioniPrimary (citable) accession number: Q18B41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: November 11, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.