ID   ACKA_CLOD6              Reviewed;         398 AA.
AC   Q18B36;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Acetate kinase;
DE            EC=2.7.2.1;
DE   AltName: Full=Acetokinase;
GN   Name=ackA; OrderedLocusNames=CD1175;
OS   Clostridium difficile (strain 630).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=272563;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16804543; DOI=10.1038/ng1830;
RA   Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA   Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA   Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA   Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA   Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA   Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K.,
RA   Unwin L., Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J.;
RT   "The multidrug-resistant human pathogen Clostridium difficile has a
RT   highly mobile, mosaic genome.";
RL   Nat. Genet. 38:779-786(2006).
CC   -!- CATALYTIC ACTIVITY: ATP + acetate = ADP + acetyl phosphate.
CC   -!- CATALYTIC ACTIVITY: ATP + propanoate = ADP + propanoyl phosphate.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; acetyl-CoA
CC       biosynthesis; acetyl-CoA from acetate: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the acetokinase family.
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DR   EMBL; AM180355; CAJ68028.1; -; Genomic_DNA.
DR   RefSeq; YP_001087667.1; -.
DR   GeneID; 4916377; -.
DR   GenomeReviews; AM180355_GR; CD1175.
DR   KEGG; cdf:CD1175; -.
DR   NMPDR; fig|1496.1.peg.221; -.
DR   HOGENOM; Q18B36; -.
DR   OMA; Q18B36; CFDTSWH.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008776; F:acetate kinase activity; IEA:HAMAP.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006082; P:organic acid metabolic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:HAMAP.
DR   HAMAP; MF_00020; -; 1.
DR   InterPro; IPR000890; Acetate_kin.
DR   InterPro; IPR004372; AckA.
DR   PANTHER; PTHR21060; Acetate_kin; 1.
DR   PANTHER; PTHR21060:SF11; AckA; 1.
DR   Pfam; PF00871; Acetate_kinase; 1.
DR   PIRSF; PIRSF000722; Acetate_prop_kin; 1.
DR   PRINTS; PR00471; ACETATEKNASE.
DR   TIGRFAMs; TIGR00016; ackA; 1.
DR   PROSITE; PS01075; ACETATE_KINASE_1; 1.
DR   PROSITE; PS01076; ACETATE_KINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding;
KW   Transferase.
FT   CHAIN         1    398       Acetate kinase.
FT                                /FTId=PRO_1000002223.
SQ   SEQUENCE   398 AA;  43320 MW;  2C94037BFFF14BC4 CRC64;
     MKILVLNCGS SSLKYQLIDM NNEEVLCIGL VERIGIEGSI LKHEKAGRDD KYVVEQPMKD
     HKDAIALVLE AVAHPEFGAV KEMKEIDAVG HRVVHAGEKF ATSVVITPEV EEALKECIDL
     APLHNPANIM GIDACKAILP DVPMVGVFDT AFHQTMPKSS YLYGLPHELY TKYGVRRYGF
     HGTSHNYVSQ RAAEILGKDI KDLKIVTCHL GNGASIAAVD GGKCVDTSMG FTPLEGLIMG
     TRCGDIDPAI LPFLMRKEGL DADGLDKLMN KESGVYGMTG ISSDFRDIED AAKNGDERAQ
     ATLEAYVKKV QKYIGAYAAE MNGLDVVVFT AGVGENGKAI RADIASNMEF LGMKLDKEAN
     DVRGKETVIS TADSKVKMLL IPTNEELMIA RDTLRLVK
//