Reviewed, UniProtKB/Swiss-Prot Q18B36 (ACKA_CLOD6)

Names and origin

Protein names

Recommended name:
    Acetate kinase
    EC=2.7.2.1
Alternative name(s):
    Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	CD1175

Organism

Clostridium difficile (strain 630) [Complete proteome] [HAMAP]

Taxonomic identifier

272563 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro phosphorylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	Acetate kinase HAMAP MF_00020		PRO_1000002223

Sequences

	Sequence		Length	Mass (Da)
	Q18B36-1 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 2C94037BFFF14BC4	FASTA	398	43,320
	10 20 30 40 50 60 MKILVLNCGS SSLKYQLIDM NNEEVLCIGL VERIGIEGSI LKHEKAGRDD KYVVEQPMKD 70 80 90 100 110 120 HKDAIALVLE AVAHPEFGAV KEMKEIDAVG HRVVHAGEKF ATSVVITPEV EEALKECIDL 130 140 150 160 170 180 APLHNPANIM GIDACKAILP DVPMVGVFDT AFHQTMPKSS YLYGLPHELY TKYGVRRYGF 190 200 210 220 230 240 HGTSHNYVSQ RAAEILGKDI KDLKIVTCHL GNGASIAAVD GGKCVDTSMG FTPLEGLIMG 250 260 270 280 290 300 TRCGDIDPAI LPFLMRKEGL DADGLDKLMN KESGVYGMTG ISSDFRDIED AAKNGDERAQ 310 320 330 340 350 360 ATLEAYVKKV QKYIGAYAAE MNGLDVVVFT AGVGENGKAI RADIASNMEF LGMKLDKEAN 370 380 390 DVRGKETVIS TADSKVKMLL IPTNEELMIA RDTLRLVK

References

[1]

"The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome." Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N., Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H., Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N., Brooks K., Chillingworth T. , Cronin A., Davis P., Dowd L., Fraser A., Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K., Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K., Unwin L., Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J. Nat. Genet. 38:779-786(2006) [PubMed: 16804543] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM180355 Genomic DNA. Translation: CAJ68028.1.
RefSeq	YP_001087667.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4916377.
GenomeReviews	Gene locus CD1175 in contig AM180355_GR.
KEGG	cdf:CD1175.
NMPDR	fig|1496.1.peg.221.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q18B36.
OMA	Q18B36. CFDTSWH.
Family and domain databases
HAMAP	MF_00020. [Tree]
InterPro	IPR000890. Acetate_kin. IPR004372. AckA. [Graphical view]
PANTHER	PTHR21060. Acetate_kin. 1 hit. PTHR21060:SF11. AckA. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. ackA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_CLOD6

Accession

Primary (citable) accession number: Q18B36

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 25, 2006
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)