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Protein

GTPase Obg

Gene

obg

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi172MagnesiumUniRule annotation1
Metal bindingi192MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi165 – 172GTPUniRule annotation8
Nucleotide bindingi190 – 194GTPUniRule annotation5
Nucleotide bindingi212 – 215GTPUniRule annotation4
Nucleotide bindingi282 – 285GTPUniRule annotation4
Nucleotide bindingi311 – 313GTPUniRule annotation3

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-1294-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase ObgUniRule annotation (EC:3.6.5.-UniRule annotation)
Alternative name(s):
GTP-binding protein ObgUniRule annotation
Gene namesi
Name:obgUniRule annotation
Ordered Locus Names:CD630_11640
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003858471 – 425GTPase ObgAdd BLAST425

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi272563.CD1164.

Structurei

3D structure databases

ProteinModelPortaliQ18B27.
SMRiQ18B27.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini159 – 330OBG-type GUniRule annotationAdd BLAST172

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9R. Bacteria.
COG0536. LUCA.
HOGENOMiHOG000019083.
KOiK03979.
OMAiPHVGIVH.

Family and domain databases

CDDicd01898. Obg. 1 hit.
Gene3Di2.70.210.12. 1 hit.
HAMAPiMF_01454. GTPase_Obg. 1 hit.
InterProiView protein in InterPro
IPR031167. G_OBG.
IPR035101. GTP-bd_Obg.
IPR014100. GTP-bd_Obg/CgtA.
IPR015349. GTP-bd_prot_GTP1/OBG_C.
IPR006074. GTP1-OBG_CS.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF09269. DUF1967. 1 hit.
PF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
PIRSFiPIRSF002401. GTP_bd_Obg/CgtA. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF102741. SSF102741. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
TIGRFAMsiTIGR02729. Obg_CgtA. 1 hit.
TIGR03595. Obg_CgtA_exten. 1 hit.
PROSITEiView protein in PROSITE
PS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18B27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIDKARIFV KAGNGGNGSV AFRREKYVPA GGPDGGDGGR GASIIFEVDL
60 70 80 90 100
GLRTLMDFKY QKKYQAQNGG DGSKGKRAGK NGENLVLKVP AGTVIRDEAT
110 120 130 140 150
GLVLADLKKE GDTAIVAKGG IGGKGNQHFA NAVRQAPAFA KSGTDGEERW
160 170 180 190 200
ITLELKMIAD VGLLGFPNVG KSTFLSVVTK AKPKIANYHF TTLTPNLGVV
210 220 230 240 250
QTKFGDSFVL ADIPGIIEGA SEGIGLGHEF LRHVERTKVL IHIVDISGLE
260 270 280 290 300
GRDPIEDFDK INDELKLYNE KLSKRPQVVV ANKFDILEDE SKFEKFKSEL
310 320 330 340 350
EGRGYTVFKM SAATRQGIDE VIAYVSKMLK EVEDVELVSE EEMYRPELDI
360 370 380 390 400
GTEEELSIDI EDGVYVVTGK ALRRIMYSVN FDDMESLQYF QKAMESQGVF
410 420
DRLREMGIED GDVVKIYELE FEFYN
Length:425
Mass (Da):46,883
Last modified:July 25, 2006 - v1
Checksum:iA993F13088273922
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ68017.1.
RefSeqiWP_009888921.1. NC_009089.1.
YP_001087656.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ68017; CAJ68017; CD630_11640.
GeneIDi31352741.
4914992.
KEGGicdf:CD630_11640.
pdc:CDIF630_01311.
PATRICifig|272563.120.peg.1214.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiOBG_PEPD6
AccessioniPrimary (citable) accession number: Q18B27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: July 25, 2006
Last modified: July 5, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families