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Protein

GTPase Obg

Gene

obg

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi172 – 1721MagnesiumUniRule annotation
Metal bindingi192 – 1921MagnesiumUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi165 – 1728GTPUniRule annotation
Nucleotide bindingi190 – 1945GTPUniRule annotation
Nucleotide bindingi212 – 2154GTPUniRule annotation
Nucleotide bindingi282 – 2854GTPUniRule annotation
Nucleotide bindingi311 – 3133GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-1327-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase ObgUniRule annotation (EC:3.6.5.-UniRule annotation)
Alternative name(s):
GTP-binding protein ObgUniRule annotation
Gene namesi
Name:obgUniRule annotation
Ordered Locus Names:CD630_11640
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425GTPase ObgPRO_0000385847Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi272563.CD1164.

Structurei

3D structure databases

ProteinModelPortaliQ18B27.
SMRiQ18B27. Positions 1-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini159 – 330172OBG-type GUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.UniRule annotation
Contains 1 OBG-type G (guanine nucleotide-binding) domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9R. Bacteria.
COG0536. LUCA.
HOGENOMiHOG000019083.
KOiK03979.
OMAiLVDFRYK.

Family and domain databases

Gene3Di2.70.210.12. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01454. GTPase_Obg. 1 hit.
InterProiIPR031167. G_OBG.
IPR014100. GTP-bd_Obg/CgtA.
IPR015349. GTP-bd_prot_GTP1/OBG_C.
IPR006074. GTP1-OBG_CS.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11702:SF3. PTHR11702:SF3. 2 hits.
PfamiPF09269. DUF1967. 1 hit.
PF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFiPIRSF002401. GTP_bd_Obg/CgtA. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF102741. SSF102741. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
TIGRFAMsiTIGR02729. Obg_CgtA. 1 hit.
TIGR03595. Obg_CgtA_exten. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18B27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIDKARIFV KAGNGGNGSV AFRREKYVPA GGPDGGDGGR GASIIFEVDL
60 70 80 90 100
GLRTLMDFKY QKKYQAQNGG DGSKGKRAGK NGENLVLKVP AGTVIRDEAT
110 120 130 140 150
GLVLADLKKE GDTAIVAKGG IGGKGNQHFA NAVRQAPAFA KSGTDGEERW
160 170 180 190 200
ITLELKMIAD VGLLGFPNVG KSTFLSVVTK AKPKIANYHF TTLTPNLGVV
210 220 230 240 250
QTKFGDSFVL ADIPGIIEGA SEGIGLGHEF LRHVERTKVL IHIVDISGLE
260 270 280 290 300
GRDPIEDFDK INDELKLYNE KLSKRPQVVV ANKFDILEDE SKFEKFKSEL
310 320 330 340 350
EGRGYTVFKM SAATRQGIDE VIAYVSKMLK EVEDVELVSE EEMYRPELDI
360 370 380 390 400
GTEEELSIDI EDGVYVVTGK ALRRIMYSVN FDDMESLQYF QKAMESQGVF
410 420
DRLREMGIED GDVVKIYELE FEFYN
Length:425
Mass (Da):46,883
Last modified:July 25, 2006 - v1
Checksum:iA993F13088273922
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ68017.1.
RefSeqiWP_009888921.1. NZ_CP010905.1.
YP_001087656.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ68017; CAJ68017; CD630_11640.
GeneIDi4914992.
KEGGicdf:CD630_11640.
pdc:CDIF630_01311.
PATRICi19440669. VBICloDif38397_1222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ68017.1.
RefSeqiWP_009888921.1. NZ_CP010905.1.
YP_001087656.1. NC_009089.1.

3D structure databases

ProteinModelPortaliQ18B27.
SMRiQ18B27. Positions 1-342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD1164.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ68017; CAJ68017; CD630_11640.
GeneIDi4914992.
KEGGicdf:CD630_11640.
pdc:CDIF630_01311.
PATRICi19440669. VBICloDif38397_1222.

Phylogenomic databases

eggNOGiENOG4105C9R. Bacteria.
COG0536. LUCA.
HOGENOMiHOG000019083.
KOiK03979.
OMAiLVDFRYK.

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-1327-MONOMER.

Family and domain databases

Gene3Di2.70.210.12. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01454. GTPase_Obg. 1 hit.
InterProiIPR031167. G_OBG.
IPR014100. GTP-bd_Obg/CgtA.
IPR015349. GTP-bd_prot_GTP1/OBG_C.
IPR006074. GTP1-OBG_CS.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11702:SF3. PTHR11702:SF3. 2 hits.
PfamiPF09269. DUF1967. 1 hit.
PF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFiPIRSF002401. GTP_bd_Obg/CgtA. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF102741. SSF102741. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
TIGRFAMsiTIGR02729. Obg_CgtA. 1 hit.
TIGR03595. Obg_CgtA_exten. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOBG_PEPD6
AccessioniPrimary (citable) accession number: Q18B27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: July 25, 2006
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.